Wnt-10a is a protein that in humans is encoded by the WNT10A gene. [5] [6] [7]
Wnt-10a is a protein that in humans is encoded by the WNT10A gene. [5] [6] [7]
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. [5]
WNT10A is strongly expressed in the cell lines of promyelocytic leukemia and Burkitt's lymphoma. In addition, it and another family member, the WNT6 gene, are strongly coexpressed in colorectal cancer cell lines. The gene overexpression may play key roles in carcinogenesis through activation of the WNT-beta-catenin-TCF signaling pathway. This gene and the WNT6 gene are clustered in the chromosome 2q35 region. [5]
Mutations in the WNT10A gene are associated with Schöpf–Schulz–Passarge syndrome [8] and hypodontia. [9]
Tyrosine-protein kinase transmembrane receptor ROR2, also known as neurotrophic tyrosine kinase, receptor-related 2, is a protein that in humans is encoded by the ROR2 gene located on position 9 of the long arm of chromosome 9. This protein is responsible for aspects of bone and cartilage growth. It is involved in Robinow syndrome and autosomal dominant brachydactyly type B. ROR2 is a member of the receptor tyrosine kinase-like orphan receptor (ROR) family.
Rosselli–Gulienetti syndrome, also known as Zlotogora–Ogur syndrome and Bowen–Armstrong syndrome, is a type of congenital ectodermal dysplasia syndrome. The syndrome is relatively rare and has only been described in a few cases.
LIM homeobox transcription factor 1-beta, also known as LMX1B, is a protein which in humans is encoded by the LMX1B gene.
Cartilage associated protein is a protein that in humans is encoded by the CRTAP gene.
Proto-oncogene Wnt-1, or Proto-oncogene Int-1 homolog is a protein that in humans is encoded by the WNT1 gene.
Ectodysplasin A (EDA) is a protein that in humans is encoded by the EDA gene.
Progressive ankylosis protein homolog is a protein that in humans is encoded by the ANKH gene.
Filamin B, beta (FLNB), also known as Filamin B, beta , is a cytoplasmic protein which in humans is encoded by the FLNB gene.
Plakophilin-1 is a protein that in humans is encoded by the PKP1 gene.
Homeobox protein DLX-3 is a protein that in humans is encoded by the DLX3 gene.
Collagen alpha-2(IX) chain is a protein that in humans is encoded by the COL9A2 gene.
DnaJ homolog subfamily B member 2 is a protein that in humans is encoded by the DNAJB2 gene.
Proto-oncogene protein Wnt-3 is a protein that in humans is encoded by the WNT3 gene.
Cytoplasmic dynein 2 heavy chain 1 is a protein that in humans is encoded by the DYNC2H1 gene.
Protein Wnt-10b is a protein that in humans is encoded by the WNT10B gene.
Dymeclin is a protein that in humans is encoded by the DYM gene.
EEM syndrome is an autosomal recessive congenital malformation disorder affecting tissues associated with the ectoderm, and also the hands, feet and eyes.
Schöpf–Schulz–Passarge syndrome is an autosomal recessive condition with punctate symmetric palmoplantar keratoderma, with the keratoderma and fragility of the nails beginning around age 12. In addition to palmoplantar keratoderma, other symptoms include hypodontia, hypotrichosis, nail dystrophies, and eyelid cysts. Patients may also develop syringofibroadenoma and squamous cell carcinomas.
Homeobox protein Hox-A2 is a protein that in humans is encoded by the HOXA2 gene.
Odontoonychodermal dysplasia is a rare genetic disorder which is characterized by systemic abnormalities of the teeth, the nails of the fingers and toes, the skin, the hair cells, and the sweat glands. It is a type of syndromic ectodermal dysplasia.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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