WNT5B

WNT5B
Identifiers
Aliases	WNT5B , Wnt family member 5B
External IDs	OMIM: 606361 MGI: 98959 HomoloGene: 22530 GeneCards: WNT5B
Gene location (Human) Chr. Chromosome 12 (human) [1] Band 12p13.33 Start 1,529,891 bp [1] End 1,647,243 bp [1]
Gene location (Mouse) Chr. Chromosome 6 (mouse) [2] Band 6 F1|6 56.86 cM Start 119,432,531 bp [2] End 119,544,347 bp [2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0005110 frizzled binding • signaling receptor binding Cellular component • endocytic vesicle membrane • endoplasmic reticulum lumen • plasma membrane • extracellular region • cell surface • Golgi lumen • extracellular exosome • extracellular space • GO:0005578 extracellular matrix • collagen-containing extracellular matrix Biological process • cellular response to retinoic acid • cell fate commitment • chondrocyte differentiation • positive regulation of cell migration • wound healing • multicellular organism development • neuron differentiation • positive regulation of fat cell differentiation • fat cell differentiation • negative regulation of canonical Wnt signaling pathway • lens fiber cell development • Wnt signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	81029	22419
Ensembl	ENSG00000111186	ENSMUSG00000030170
UniProt	Q9H1J7	P22726
RefSeq (mRNA)	NM_030775 NM_032642	NM_001271757 NM_001271758 NM_009525
RefSeq (protein)	NP_110402 NP_116031	NP_001258686 NP_001258687 NP_033551
Location (UCSC)	Chr 12: 1.53 – 1.65 Mb	Chr 6: 119.43 – 119.54 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Protein Wnt-5b is a protein that in humans is encoded by the WNT5B gene. ^{[5] [6]}

The WNT gene family consists of structurally-related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein showing 94% and 80% amino acid identity to the mouse Wnt5b protein and the human WNT5A protein, respectively. Alternative splicing of this gene generates two transcript variants. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000111186 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000030170 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Saitoh T, Katoh M (Jul 2001). "Molecular cloning and characterization of human WNT5B on chromosome 12p13.3 region". Int J Oncol. 19 (2): 347–51. doi:10.3892/ijo.19.2.347. PMID   11445850.
6. "Entrez Gene: WNT5B wingless-type MMTV integration site family, member 5B".

Further reading

• Smolich BD, McMahon JA, McMahon AP, Papkoff J (1994). "Wnt family proteins are secreted and associated with the cell surface". Mol. Biol. Cell. 4 (12): 1267–75. doi:10.1091/mbc.4.12.1267. PMC   275763 . PMID   8167409.
• Tanaka K, Okabayashi K, Asashima M, et al. (2000). "The evolutionarily conserved porcupine gene family is involved in the processing of the Wnt family". Eur. J. Biochem. 267 (13): 4300–11. doi:10.1046/j.1432-1033.2000.01478.x. PMID   10866835.
• Saitoh T, Katoh M (2003). "Expression and regulation of WNT5A and WNT5B in human cancer: up-regulation of WNT5A by TNFalpha in MKN45 cells and up-regulation of WNT5B by beta-estradiol in MCF-7 cells". Int. J. Mol. Med. 10 (3): 345–9. doi:10.3892/ijmm.10.3.345. PMID   12165812.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Kanazawa A, Tsukada S, Sekine A, et al. (2005). "Association of the Gene Encoding Wingless-Type Mammary Tumor Virus Integration-Site Family Member 5B (WNT5B) with Type 2 Diabetes". Am. J. Hum. Genet. 75 (5): 832–43. doi:10.1086/425340. PMC   1182112 . PMID   15386214.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Mangioni S, Viganò P, Lattuada D, et al. (2005). "Overexpression of the Wnt5b gene in leiomyoma cells: implications for a role of the Wnt signaling pathway in the uterine benign tumor". J. Clin. Endocrinol. Metab. 90 (9): 5349–55. doi: 10.1210/jc.2005-0272 . PMID   15972578.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.