WNT8B

WNT8B
Identifiers
Aliases	WNT8B , Wnt family member 8B
External IDs	OMIM: 601396 MGI: 109485 HomoloGene: 2550 GeneCards: WNT8B
Gene location (Human) Chr. Chromosome 10 (human) [1] Band 10q24.31 Start 100,463,009 bp [1] End 100,483,744 bp [1]
Gene location (Mouse) Chr. Chromosome 19 (mouse) [2] Band 19 C3|19 37.98 cM Start 44,481,911 bp [2] End 44,502,712 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in kidney body of pancreas renal cortex liver urinary bladder prostate Right adrenal gland muscle of leg mouth salivary gland Top expressed in corneal epithelium vein ascending aorta corneal endothelium aortic valve corneal stroma surface ectoderm renal corpuscle thymus superior frontal gyrus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function signaling receptor binding frizzled binding receptor ligand activity Cellular component extracellular region extracellular space Biological process multicellular organism development cellular response to retinoic acid cell fate commitment determination of dorsal identity response to estradiol gastrulation response to retinoic acid neuron differentiation signal transduction nervous system development beta-catenin destruction complex disassembly Wnt signaling pathway regulation of signaling receptor activity canonical Wnt signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7479 22423 Ensembl ENSG00000075290 ENSMUSG00000036961 UniProt Q93098 Q9WUD6 RefSeq (mRNA) NM_003393 NM_011720 RefSeq (protein) NP_003384 n/a Location (UCSC) Chr 10: 100.46 – 100.48 Mb Chr 19: 44.48 – 44.5 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Protein Wnt-8b is a protein that in humans is encoded by the WNT8B gene. ^{[5] [6]}

The WNT gene family consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis.

This gene is a member of the WNT gene family. It encodes a protein showing 95%, 86%, and 71% amino acid identity to the mouse, zebrafish and Xenopus Wnt8B proteins, respectively. The expression patterns of the human and mouse genes appear identical and are restricted to the developing brain. The chromosomal location of this gene to 10q24 suggests it as a candidate gene for partial epilepsy. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000075290 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000036961 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Lako M, Strachan T, Curtis AR, Lindsay S (Sep 1996). "Isolation and characterization of WNT8B, a novel human Wnt gene that maps to 10q24". Genomics. 35 (2): 386–8. doi:10.1006/geno.1996.0374. PMID   8661156.
6. "Entrez Gene: WNT8B wingless-type MMTV integration site family, member 8B".

Further reading

• Katoh M, Katoh M (2007). "Conserved POU/OCT- and GATA-binding sites in 5'-flanking promoter region of mammalian WNT8B orthologs". Int. J. Oncol. 30 (5): 1273–7. doi: 10.3892/ijo.30.5.1273 . PMID   17390031.
• Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. Bibcode:2004Natur.429..375D. doi: 10.1038/nature02462 . PMID   15164054.
• Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID   15146197. S2CID   27764390.
• Saitoh T, Mine T, Katoh M (2002). "Expression and regulation of WNT8A and WNT8B mRNAs in human tumor cell lines: up-regulation of WNT8B mRNA by beta-estradiol in MCF-7 cells, and down-regulation of WNT8A and WNT8B mRNAs by retinoic acid in NT2 cells". Int. J. Oncol. 20 (5): 999–1003. doi:10.3892/ijo.20.5.999. PMID   11956596.
• Saitoh T, Mine T, Katoh M (2002). "Up-regulation of WNT8B mRNA in human gastric cancer". Int. J. Oncol. 20 (2): 343–8. doi:10.3892/ijo.20.2.343. PMID   11788899.
• Lako M, Lindsay S, Bullen P, et al. (1998). "A novel mammalian wnt gene, WNT8B, shows brain-restricted expression in early development, with sharply delimited expression boundaries in the developing forebrain". Hum. Mol. Genet. 7 (5): 813–22. doi: 10.1093/hmg/7.5.813 . PMID   9536085.
• Smolich BD, McMahon JA, McMahon AP, Papkoff J (1994). "Wnt family proteins are secreted and associated with the cell surface". Mol. Biol. Cell. 4 (12): 1267–75. doi:10.1091/mbc.4.12.1267. PMC   275763 . PMID   8167409.