WNT3

WNT3
Identifiers
Aliases	WNT3 , INT4, TETAMS, Wnt family member 3
External IDs	OMIM: 165330 MGI: 98955 HomoloGene: 22527 GeneCards: WNT3
Gene location (Human) Chr. Chromosome 17 (human) [1] Band 17q21.31-q21.32 Start 46,762,506 bp [1] End 46,833,154 bp [1]
Gene location (Mouse) Chr. Chromosome 11 (mouse) [2] Band 11 E1|11 67.5 cM Start 103,664,976 bp [2] End 103,708,783 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of abdomen hypothalamus dorsolateral prefrontal cortex substantia nigra right lobe of liver Brodmann area 9 prefrontal cortex amygdala superior frontal gyrus nucleus accumbens Top expressed in surface ectoderm rhombic lip lip pretectal area intestinal villus enamel knot cerebellar cortex lateral habenular nucleus medial habenular nucleus mesoderm More reference expression data BioGPS More reference expression data
Gene ontology Molecular function receptor ligand activity protein domain specific binding frizzled binding protein binding signaling receptor binding Cellular component cytoplasm endocytic vesicle membrane Wnt signalosome endoplasmic reticulum lumen plasma membrane extracellular region Golgi lumen extracellular exosome extracellular space extracellular matrix Biological process cellular response to retinoic acid cell fate commitment Spemann organizer formation at the anterior end of the primitive streak head morphogenesis limb bud formation mammary gland epithelium development anatomical structure formation involved in morphogenesis mesoderm formation positive regulation of collateral sprouting in absence of injury negative regulation of axon extension involved in axon guidance dorsal/ventral axis specification axon guidance limb development multicellular organism development positive regulation of Wnt signaling pathway gamete generation canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation canonical Wnt signaling pathway involved in osteoblast differentiation cell morphogenesis canonical Wnt signaling pathway anterior/posterior axis specification embryonic forelimb morphogenesis anterior/posterior pattern specification embryonic hindlimb morphogenesis Wnt signaling pathway positive regulation of gene expression regulation of neurogenesis stem cell proliferation canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation canonical Wnt signaling pathway involved in stem cell proliferation neuron differentiation regulation of signaling receptor activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7473 22415 Ensembl ENSG00000108379 ENSG00000277641 ENSG00000277626 ENSMUSG00000000125 UniProt P56703 P17553 RefSeq (mRNA) NM_030753 NM_009521 RefSeq (protein) NP_110380 NP_033547 Location (UCSC) Chr 17: 46.76 – 46.83 Mb Chr 11: 103.66 – 103.71 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Proto-oncogene protein Wnt-3 is a protein that in humans is encoded by the WNT3 gene. ^{[5] [6]}

The WNT gene family consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein showing 98% amino acid identity to mouse Wnt3 protein, and 84% to human WNT3A protein, another WNT gene product. The mouse studies show the requirement of Wnt3 in primary axis formation in the mouse. Studies of the gene expression suggest that this gene may play a key role in some cases of human breast, rectal, lung, and gastric cancer through activation of the WNT-beta-catenin-TCF signaling pathway. This gene is clustered with WNT15, another family member, in the chromosome 17q21 region. ^[6]

References

1. ENSG00000277641, ENSG00000277626 GRCh38: Ensembl release 89: ENSG00000108379, ENSG00000277641, ENSG00000277626 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000000125 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Roelink H, Wang J, Black DM, Solomon E, Nusse R (Dec 1993). "Molecular cloning and chromosomal localization to 17q21 of the human WNT3 gene". Genomics. 17 (3): 790–2. doi:10.1006/geno.1993.1412. PMID   8244403.
6. "Entrez Gene: WNT3 wingless-type MMTV integration site family, member 3".

External links

• GeneReviews/NIH/NCBI/UW entry on Tetra-Amelia Syndrome

Further reading

• Nusse R, Brown A, Papkoff J, et al. (1991). "A new nomenclature for int-1 and related genes: the Wnt gene family". Cell. 64 (2): 231. doi:10.1016/0092-8674(91)90633-A. PMID   1846319. S2CID   3189574.
• Smolich BD, McMahon JA, McMahon AP, Papkoff J (1994). "Wnt family proteins are secreted and associated with the cell surface". Mol. Biol. Cell. 4 (12): 1267–75. doi:10.1091/mbc.4.12.1267. PMC   275763 . PMID   8167409.
• Liu P, Wakamiya M, Shea MJ, et al. (1999). "Requirement for Wnt3 in vertebrate axis formation". Nat. Genet. 22 (4): 361–5. doi:10.1038/11932. PMID   10431240. S2CID   22195563.
• Gazit A, Yaniv A, Bafico A, et al. (1999). "Human frizzled 1 interacts with transforming Wnts to transduce a TCF dependent transcriptional response". Oncogene. 18 (44): 5959–66. doi: 10.1038/sj.onc.1202985 . PMID   10557084.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC   310948 . PMID   11076863.
• Katoh M (2002). "Molecular cloning and characterization of human WNT3". Int. J. Oncol. 19 (5): 977–82. doi:10.3892/ijo.19.5.977. PMID   11604997.
• Katoh M (2002). "Regulation of WNT3 and WNT3A mRNAs in human cancer cell lines NT2, MCF-7, and MKN45". Int. J. Oncol. 20 (2): 373–7. doi:10.3892/ijo.20.2.373. PMID   11788904.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Niemann S, Zhao C, Pascu F, et al. (2004). "Homozygous WNT3 Mutation Causes Tetra-Amelia in a Large Consanguineous Family". Am. J. Hum. Genet. 74 (3): 558–63. doi:10.1086/382196. PMC   1182269 . PMID   14872406.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Chiba H, Kobune M, Kato J, et al. (2005). "Wnt3 modulates the characteristics and cobblestone area-supporting activity of human stromal cells". Exp. Hematol. 32 (12): 1194–203. doi: 10.1016/j.exphem.2004.08.010 . PMID   15588944.
• Yamamoto H, Komekado H, Kikuchi A (2006). "Caveolin is necessary for Wnt-3a-dependent internalization of LRP6 and accumulation of beta-catenin". Dev. Cell. 11 (2): 213–23. doi: 10.1016/j.devcel.2006.07.003 . PMID   16890161.