WNT2B

WNT2B
Identifiers
Aliases	WNT2B , WNT13, Wnt family member 2B
External IDs	OMIM: 601968 MGI: 1261834 HomoloGene: 22526 GeneCards: WNT2B
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1p13.2 Start 112,466,541 bp [1] End 112,530,165 bp [1]
Gene location (Mouse) Chr. Chromosome 3 (mouse) [2] Band 3 F2.2|3 45.88 cM Start 104,852,588 bp [2] End 104,869,237 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in germinal epithelium parietal pleura optic nerve right lung vagina skin of abdomen visceral pleura retinal pigment epithelium nipple rectum Top expressed in pretectal area vagina aortic valve endolymphatic sac third ventricle ascending aorta sclerotome esophagus squamous epithelium mesoderm More reference expression data BioGPS More reference expression data
Gene ontology Molecular function frizzled binding signaling receptor binding Cellular component extracellular region extracellular space intracellular membrane-bounded organelle collagen-containing extracellular matrix Biological process cell fate commitment positive regulation of branching involved in ureteric bud morphogenesis male gonad development chondrocyte differentiation positive regulation of canonical Wnt signaling pathway iris morphogenesis cornea development in camera-type eye cellular response to starvation hematopoietic stem cell proliferation lung induction multicellular organism development forebrain regionalization lens development in camera-type eye neuron differentiation mesenchymal-epithelial cell signaling canonical Wnt signaling pathway Wnt signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7482 22414 Ensembl ENSG00000134245 ENSMUSG00000027840 UniProt Q93097 O70283 RefSeq (mRNA) NM_024494 NM_001291880 NM_004185 NM_009520 RefSeq (protein) NP_001278809 NP_004176 NP_078613 NP_033546 Location (UCSC) Chr 1: 112.47 – 112.53 Mb Chr 3: 104.85 – 104.87 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Protein Wnt-2b (formerly Wnt13 ^[5] ) is a protein that in humans is encoded by the WNT2B gene. ^{[6] [7] [8]}

This gene encodes a member of the wingless-type MMTV integration site (WNT) family of highly conserved, secreted signaling factors. WNT family members function in a variety of developmental processes including regulation of cell growth and differentiation and are characterized by a WNT-core domain. This gene may play a role in human development as well as human carcinogenesis. This gene produces two alternative transcript variants. ^[8]

References

1. GRCh38: Ensembl release 89: ENSG00000134245 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000027840 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Kubo F, Takeichi M, Nakagawa S (2003). "Wnt2b controls retinal cell differentiation at the ciliary marginal zone". Development. 130 (3): 587–98. doi:10.1242/dev.00244. PMID   12490564.
6. Katoh M, Hirai M, Sugimura T, Terada M (Oct 1996). "Cloning, expression and chromosomal localization of Wnt-13, a novel member of the Wnt gene family". Oncogene. 13 (4): 873–6. PMID   8761309.
7. Katoh M, Kirikoshi H, Saitoh T, Sagara N, Koike J (Sep 2000). "Alternative splicing of the WNT-2B/WNT-13 gene". Biochem Biophys Res Commun. 275 (1): 209–16. doi:10.1006/bbrc.2000.3252. PMID   10944466.
8. "Entrez Gene: WNT2B wingless-type MMTV integration site family, member 2B".

Further reading

• Katoh M (2006). "WNT2B: comparative integromics and clinical applications (Review)". Int. J. Mol. Med. 16 (6): 1103–8. doi:10.3892/ijmm.16.6.1103. PMID   16273293.
• Smolich BD, McMahon JA, McMahon AP, Papkoff J (1994). "Wnt family proteins are secreted and associated with the cell surface". Mol. Biol. Cell. 4 (12): 1267–75. doi:10.1091/mbc.4.12.1267. PMC   275763 . PMID   8167409.
• Bergstein I, Eisenberg LM, Bhalerao J, et al. (1998). "Isolation of two novel WNT genes, WNT14 and WNT15, one of which (WNT15) is closely linked to WNT3 on human chromosome 17q21". Genomics. 46 (3): 450–8. doi: 10.1006/geno.1997.5041 . PMID   9441749.
• Katoh M (2002). "Differential regulation of WNT2 and WNT2B expression in human cancer". Int. J. Mol. Med. 8 (6): 657–60. doi:10.3892/ijmm.8.6.657. PMID   11712082.
• Yarden RI, Brody LC (2002). "Identification of proteins that interact with BRCA1 by Far-Western library screening". J. Cell. Biochem. 83 (4): 521–31. doi:10.1002/jcb.1257. PMID   11746496. S2CID   29703139.
• Ricken A, Lochhead P, Kontogiannea M, Farookhi R (2002). "Wnt signaling in the ovary: identification and compartmentalized expression of wnt-2, wnt-2b, and frizzled-4 mRNAs". Endocrinology. 143 (7): 2741–9. doi: 10.1210/endo.143.7.8908 . PMID   12072409.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Katoh M (2005). "Molecular evolution of Wnt2b orthologs". Int. J. Oncol. 26 (4): 1135–9. doi:10.3892/ijo.26.4.1135. PMID   15754012.
• Struewing IT, Toborek A, Mao CD (2006). "Mitochondrial and nuclear forms of Wnt13 are generated via alternative promoters, alternative RNA splicing, and alternative translation start sites". J. Biol. Chem. 281 (11): 7282–93. doi: 10.1074/jbc.M511182200 . PMID   16407296.