WNT2B

Last updated

WNT2B
Identifiers
Aliases WNT2B , WNT13, Wnt family member 2B
External IDs OMIM: 601968; MGI: 1261834; HomoloGene: 22526; GeneCards: WNT2B; OMA:WNT2B - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_024494
NM_001291880
NM_004185

NM_009520

RefSeq (protein)

NP_001278809
NP_004176
NP_078613

NP_033546

Location (UCSC) Chr 1: 112.47 – 112.53 Mb Chr 3: 104.85 – 104.87 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Protein Wnt-2b (formerly Wnt13 [5] ) is a protein that in humans is encoded by the WNT2B gene. [6] [7] [8]

This gene encodes a member of the wingless-type MMTV integration site (WNT) family of highly conserved, secreted signaling factors. WNT family members function in a variety of developmental processes including regulation of cell growth and differentiation and are characterized by a WNT-core domain. This gene may play a role in human development as well as human carcinogenesis. This gene produces two alternative transcript variants. [8]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000134245 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000027840 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Kubo F, Takeichi M, Nakagawa S (2003). "Wnt2b controls retinal cell differentiation at the ciliary marginal zone". Development. 130 (3): 587–98. doi:10.1242/dev.00244. PMID   12490564. S2CID   6642249.
  6. Katoh M, Hirai M, Sugimura T, Terada M (Oct 1996). "Cloning, expression and chromosomal localization of Wnt-13, a novel member of the Wnt gene family". Oncogene. 13 (4): 873–6. PMID   8761309.
  7. Katoh M, Kirikoshi H, Saitoh T, Sagara N, Koike J (Sep 2000). "Alternative splicing of the WNT-2B/WNT-13 gene". Biochem Biophys Res Commun. 275 (1): 209–16. doi:10.1006/bbrc.2000.3252. PMID   10944466.
  8. 1 2 "Entrez Gene: WNT2B wingless-type MMTV integration site family, member 2B".

Further reading