Indantadol

Last updated
Indantadol
Indantadol.svg
Clinical data
Routes of
administration
Oral
ATC code
  • none
Legal status
Legal status
  • In general: uncontrolled
Identifiers
  • N-(2,3-dihydro-1H-inden-2-yl)glycinamide
CAS Number
ChemSpider
UNII
CompTox Dashboard (EPA)
Chemical and physical data
Formula C11H14N2O
Molar mass 190.246 g·mol−1
3D model (JSmol)
  • NCC(=O)NC1Cc2ccccc2C1

Indantadol (CHF-3381, V-3381) is a drug which was formerly being investigated as an anticonvulsant and neuroprotective and is now under development for the treatment of neuropathic pain and chronic cough in Europe by Vernalis and Chiesi. [1] [2] [3] [4] [5] [6] [7] [8] It acts as a competitive, reversible, and non-selective monoamine oxidase inhibitor, [5] [6] [9] and as a low affinity, non-competitive NMDA receptor antagonist. [1] [2] [10] A pilot study of indantadol for chronic cough was initiated in October 2009 and in April 2010 it failed to achieve significant efficacy in neuropathic pain in phase IIb clinical trials. [7] [8] [11] [12]

See also

Related Research Articles

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References

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  11. "V3381CC". Archived from the original on 2014-08-13.
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