Elsamitrucin

Last updated
Elsamitrucin
Elsamicin A.png
Clinical data
ATC code
  • none
Identifiers
  • 10-[3-(3-Amino-5-hydroxy-4-methoxy-6-methyl-tetrahydro-pyran-2-yloxy)-4,5-dihydroxy-4,6-dimethyl-tetrahydro-pyran-2-yloxy]-6-hydroxy-1-methyl-benzo[h]chromeno[5,4,3-cde]chromene-5,12-dione
CAS Number
PubChem CID
ChemSpider
UNII
Chemical and physical data
Formula C33H35NO13
Molar mass 653.637 g·mol−1
3D model (JSmol)
  • Cc1ccc2c3c1c(=O)oc4c3c(c(c5c4c(ccc5)O[C@H]6[C@@H]([C@@]([C@H]([C@H](O6)C)O)(C)O)O[C@@H]7[C@@H]([C@H]([C@H]([C@H](O7)C)O)OC)N)O)c(=O)o2
  • InChI=1S/C33H35NO13/c1-11-9-10-16-19-17(11)29(38)46-25-18-14(24(36)21(20(19)25)30(39)44-16)7-6-8-15(18)45-32-28(33(4,40)27(37)13(3)43-32)47-31-22(34)26(41-5)23(35)12(2)42-31/h6-10,12-13,22-23,26-28,31-32,35-37,40H,34H2,1-5H3/t12-,13-,22-,23+,26-,27+,28+,31-,32+,33+/m1/s1
  • Key:MGQRRMONVLMKJL-KWJIQSIXSA-N
   (verify)

Elsamitrucin (elsamicin A) is a drug used in chemotherapy. [1] Elsamitrucin is chemically related to chartreusin.[ citation needed ]

Related Research Articles

Artificial intelligence (AI) is intelligence—perceiving, synthesizing, and inferring information—demonstrated by machines, as opposed to intelligence displayed by non-human animals and humans. Example tasks in which this is done include speech recognition, computer vision, translation between (natural) languages, as well as other mappings of inputs.

<span class="mw-page-title-main">Bird</span> Warm-blooded, egg-laying vertebrates with wings, feathers, and beaks

Birds are a group of warm-blooded vertebrates constituting the class Aves, characterised by feathers, toothless beaked jaws, the laying of hard-shelled eggs, a high metabolic rate, a four-chambered heart, and a strong yet lightweight skeleton. Birds live worldwide and range in size from the 5.5 cm (2.2 in) bee hummingbird to the 2.8 m common ostrich. There are about ten thousand living species, more than half of which are passerine, or "perching" birds. Birds have wings whose development varies according to species; the only known groups without wings are the extinct moa and elephant birds. Wings, which are modified forelimbs, gave birds the ability to fly, although further evolution has led to the loss of flight in some birds, including ratites, penguins, and diverse endemic island species. The digestive and respiratory systems of birds are also uniquely adapted for flight. Some bird species of aquatic environments, particularly seabirds and some waterbirds, have further evolved for swimming.

<span class="mw-page-title-main">Chordate</span> Phylum of animals having a dorsal nerve cord

A chordate is an animal of the phylum Chordata. All chordates possess, at some point during their larval or adult stages, five synapomorphies, or primary physical characteristics, that distinguish them from all the other taxa. These five synapomorphies include a notochord, dorsal hollow nerve cord, endostyle or thyroid, pharyngeal slits, and a post-anal tail. The name “chordate” comes from the first of these synapomorphies, the notochord, which plays a significant role in chordate structure and movement. Chordates are also bilaterally symmetric, have a coelom, possess a circulatory system, and exhibit metameric segmentation.

<span class="mw-page-title-main">Cat</span> Small domesticated carnivorous mammal

The cat is a domestic species of small carnivorous mammal. It is the only domesticated species in the family Felidae and is commonly referred to as the domestic cat or house cat to distinguish it from the wild members of the family. Cats are commonly kept as house pets but can also be farm cats or feral cats; the feral cat ranges freely and avoids human contact. Domestic cats are valued by humans for companionship and their ability to kill rodents. About 60 cat breeds are recognized by various cat registries.

<span class="mw-page-title-main">Dinosaur</span> Clade of sauropsid vertebrates that dominated the Mesozoic Era (including birds)

Dinosaurs are a diverse group of reptiles of the clade Dinosauria. They first appeared during the Triassic period, between 245 and 233.23 million years ago (mya), although the exact origin and timing of the evolution of dinosaurs is a subject of active research. They became the dominant terrestrial vertebrates after the Triassic–Jurassic extinction event 201.3 mya and their dominance continued throughout the Jurassic and Cretaceous periods. The fossil record shows that birds are feathered dinosaurs, having evolved from earlier theropods during the Late Jurassic epoch, and are the only dinosaur lineage known to have survived the Cretaceous–Paleogene extinction event approximately 66 mya. Dinosaurs can therefore be divided into avian dinosaurs—birds—and the extinct non-avian dinosaurs, which are all dinosaurs other than birds.

<span class="mw-page-title-main">Hydrogen</span> Chemical element, symbol H and atomic number

Hydrogen is the chemical element with the symbol H and atomic number 1. Hydrogen is the lightest element. At standard conditions hydrogen is a gas of diatomic molecules having the formula H2. It is colorless, odorless, tasteless, non-toxic, and highly combustible. Hydrogen is the most abundant chemical substance in the universe, constituting roughly 75% of all normal matter. Stars such as the Sun are mainly composed of hydrogen in the plasma state. Most of the hydrogen on Earth exists in molecular forms such as water and organic compounds. For the most common isotope of hydrogen each atom has one proton, one electron, and no neutrons.

<span class="mw-page-title-main">J. R. R. Tolkien</span> English philologist and author (1892–1973)

John Ronald Reuel Tolkien was an English writer and philologist. He was the author of the high fantasy works The Hobbit and The Lord of the Rings.

<span class="mw-page-title-main">Solar System</span> The Sun and objects orbiting it

The Solar System is the gravitationally bound system of the Sun and the objects that orbit it. It formed 4.6 billion years ago from the gravitational collapse of a giant interstellar molecular cloud. The vast majority (99.86%) of the system's mass is in the Sun, with most of the remaining mass contained in the planet Jupiter. The planetary system around the Sun contains eight planets. The four inner system planets—Mercury, Venus, Earth and Mars—are terrestrial planets, being composed primarily of rock and metal. The four giant planets of the outer system are substantially larger and more massive than the terrestrials. The two largest, Jupiter and Saturn, are gas giants, being composed mainly of hydrogen and helium; the next two, Uranus and Neptune, are ice giants, being composed mostly of volatile substances with relatively high melting points compared with hydrogen and helium, such as water, ammonia, and methane. All eight planets have nearly circular orbits that lie near the plane of Earth's orbit, called the ecliptic.

<span class="mw-page-title-main">Jupiter</span> Fifth planet from the Sun

Jupiter is the fifth planet from the Sun and the largest in the Solar System. It is a gas giant with a mass more than two and a half times that of all the other planets in the Solar System combined, and slightly less than one one-thousandth the mass of the Sun. Jupiter is the third brightest natural object in the Earth's night sky after the Moon and Venus, and it has been observed since prehistoric times. It was named after Jupiter, the chief deity of ancient Roman religion.

<span class="mw-page-title-main">Umayyad Caliphate</span> Second Islamic caliphate (661–750 CE)

The Umayyad Caliphate was the second caliphate established after the death of the Islamic prophet Muhammad. The caliphate was ruled by the Umayyad dynasty. Uthman ibn Affan, the third of the Rashidun caliphs, was also a member of the clan. The family established dynastic, hereditary rule with Muawiya ibn Abi Sufyan, long-time governor of Greater Syria, who became caliph after the end of the First Fitna in 661. After Mu'awiya's death in 680, conflicts over the succession resulted in the Second Fitna, and power eventually fell to Marwan I, from another branch of the clan. Syria remained the Umayyads' main power base thereafter, with Damascus as their capital.

<span class="mw-page-title-main">J1 League</span> Top division of association football in Japan

The J1 League, known as the Meiji Yasuda J1 League for sponsorship reasons, is the top level of the Japan Professional Football League system. Founded in 1992, it is one of the most successful leagues in Asian club football. Contested by 18 clubs, it operates on a system of promotion and relegation with the J2 League. Until the 2014 season, it was known as the J League Division 1.

The voiced palatal approximant, or yod, is a type of consonant used in many spoken languages. The symbol in the International Phonetic Alphabet that represents this sound is ⟨j⟩. The equivalent X-SAMPA symbol is j, and in the Americanist phonetic notation it is ⟨y⟩. Because the English name of the letter J, jay, starts with, the approximant is sometimes instead called yod (jod), as in the phonological history terms yod-dropping and yod-coalescence.

<span class="mw-page-title-main">Yokohama F. Marinos</span> Japanese football club

Yokohama F. Marinos is a Japanese professional football club based in Yokohama, Kanagawa Prefecture, part of the Greater Tokyo Area. The club competes in the J1 League, which is the top tier of football in the country.

<span class="mw-page-title-main">FC Tokyo</span> Japanese professional football club

Football Club Tokyo, commonly known as FC Tokyo, is a Japanese professional football club based in Chōfu, Tokyo. The club plays in the J1 League, the top tier of football in the country. The team is one of four in the J.League to be simply called Football Club without an extended name.

<span class="mw-page-title-main">J</span> Tenth letter of the Latin alphabet

J, or j, is the tenth letter in the Latin alphabet, used in the modern English alphabet, the alphabets of other western European languages and others worldwide. Its usual name in English is jay, with a now-uncommon variant jy. When used in the International Phonetic Alphabet for the y sound, it may be called yod or jod.

<span class="mw-page-title-main">Bacteria</span> Domain of micro-organisms

Bacteria are ubiquitous, mostly free-living organisms often consisting of one biological cell. They constitute a large domain of prokaryotic microorganisms. Typically a few micrometres in length, bacteria were among the first life forms to appear on Earth, and are present in most of its habitats. Bacteria inhabit soil, water, acidic hot springs, radioactive waste, and the deep biosphere of Earth's crust. Bacteria are vital in many stages of the nutrient cycle by recycling nutrients such as the fixation of nitrogen from the atmosphere. The nutrient cycle includes the decomposition of dead bodies; bacteria are responsible for the putrefaction stage in this process. In the biological communities surrounding hydrothermal vents and cold seeps, extremophile bacteria provide the nutrients needed to sustain life by converting dissolved compounds, such as hydrogen sulphide and methane, to energy. Bacteria also live in symbiotic and parasitic relationships with plants and animals. Most bacteria have not been characterised and there are many species that cannot be grown in the laboratory. The study of bacteria is known as bacteriology, a branch of microbiology.

<span class="mw-page-title-main">Animal</span> Kingdom of living things

Animals are multicellular, eukaryotic organisms in the biological kingdom Animalia. With few exceptions, animals consume organic material, breathe oxygen, are able to move, can reproduce sexually, and grow from a hollow sphere of cells, the blastula, during embryonic development. Over 1.5 million living animal species have been described—of which around 1 million are insects—but it has been estimated there are over 7 million animal species in total. Animals range in length from 8.5 micrometres (0.00033 in) to 33.6 metres (110 ft). They have complex interactions with each other and their environments, forming intricate food webs. The scientific study of animals is known as zoology.

<span class="mw-page-title-main">Mollusca</span> Large phylum of invertebrate animals

Mollusca is the second-largest phylum of invertebrate animals after the Arthropoda, the members of which are known as molluscs or mollusks. Around 85,000 extant species of molluscs are recognized. The number of fossil species is estimated between 60,000 and 100,000 additional species. The proportion of undescribed species is very high. Many taxa remain poorly studied.

<span class="mw-page-title-main">Arthropod</span> Phylum of invertebrates with jointed exoskeletons

Arthropods are invertebrate animals with an exoskeleton, a segmented body, and paired jointed appendages. Arthropods form the phylum Arthropoda. They are distinguished by their jointed limbs and cuticle made of chitin, often mineralised with calcium carbonate. The arthropod body plan consists of segments, each with a pair of appendages. Arthropods are bilaterally symmetrical and their body possesses an external skeleton. In order to keep growing, they must go through stages of moulting, a process by which they shed their exoskeleton to reveal a new one. Some species have wings. They are an extremely diverse group, with up to 10 million species.

<span class="mw-page-title-main">Chartreusin</span> Chemical compound

Chartreusin is an antibiotic originally isolated from the bacteria Streptomyces Chartreusis. The crystalline compound itself has a yellow-green colour, as per its name, and is stable at room temperature for several hours. Chartreusin is chemically related to elsamitrucin, as the two share an aglycone chartarin structure, though they differ in their sugar moieties. Both chartreusin and elsamitrucin were found to have anticancer activity.

References

  1. Barceló F, Portugal J (October 2004). "Elsamicin A binding to DNA. A comparative thermodynamic characterization". FEBS Letters. 576 (1–2): 68–72. doi: 10.1016/j.febslet.2004.08.063 . PMID   15474012.