23S rRNA pseudouridine955/2504/2580 synthase

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23S rRNA pseudouridine955/2504/2580 synthase
Identifiers
EC no. 5.4.99.24
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NCBI proteins

23S rRNA pseudouridine955/2504/2580 synthase (EC 5.4.99.24, RluC, pseudouridine synthase RluC) is an enzyme with the systematic name 23S rRNA-uridine955/2504/2580 uracil mutase. [1] [2] [3] [4] This enzyme catalyses the following chemical reaction

23S rRNA uridine 955/uridine2504/uridine2580 23S rRNA pseudouridine955/pseudouridine2504/pseudouridine2580

The enzyme converts uridines at positions 955, 2504 and 2580 of 23S rRNA to pseudouridines.

References

  1. ↑ Jiang M, Sullivan SM, Walker AK, Strahler JR, Andrews PC, Maddock JR (May 2007). "Identification of novel Escherichia coli ribosome-associated proteins using isobaric tags and multidimensional protein identification techniques". Journal of Bacteriology. 189 (9): 3434–44. doi:10.1128/jb.00090-07. PMC   1855874 . PMID   17337586.
  2. ↑ Conrad J, Sun D, Englund N, Ofengand J (July 1998). "The rluC gene of Escherichia coli codes for a pseudouridine synthase that is solely responsible for synthesis of pseudouridine at positions 955, 2504, and 2580 in 23 S ribosomal RNA". The Journal of Biological Chemistry. 273 (29): 18562–6. doi: 10.1074/jbc.273.29.18562 . PMID   9660827.
  3. ↑ Corollo D, Blair-Johnson M, Conrad J, Fiedler T, Sun D, Wang L, Ofengand J, Fenna R (January 1999). "Crystallization and characterization of a fragment of pseudouridine synthase RluC from Escherichia coli" (PDF). Acta Crystallographica Section D. 55 (Pt 1): 302–4. Bibcode:1999AcCrD..55..302C. doi:10.1107/s090744499801021x. PMID   10089432.
  4. ↑ Toh SM, Mankin AS (July 2008). "An indigenous posttranscriptional modification in the ribosomal peptidyl transferase center confers resistance to an array of protein synthesis inhibitors". Journal of Molecular Biology. 380 (4): 593–7. doi:10.1016/j.jmb.2008.05.027. PMC   5367387 . PMID   18554609.
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