ASAH2B

Last updated
ASAH2B
Identifiers
Aliases ASAH2B , ASAH2L, bA449O16.3, bA98I6.3, N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2B, ASAH2C, N-acylsphingosine amidohydrolase 2B
External IDs GeneCards: ASAH2B
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001079516
NM_001321957
NM_001321958
NM_001321959
NM_001321960

Contents

n/a

RefSeq (protein)

NP_001072984
NP_001308886
NP_001308887
NP_001308888
NP_001308889

n/a

Location (UCSC) Chr 10: 50.74 – 50.82 Mb n/a
PubMed search [2] n/a
Wikidata
View/Edit Human

Neutral ceramidase B also known as non-lysosomal ceramidase B or N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2B or ASAH2B is a ceramidase enzyme which in humans is encoded by the ASAH2B gene. [3] [4]

Clinical significance

ASAH2B shows reduced expression with increasing age and further reduction in late onset Alzheimer's disease patients. [3]

Related Research Articles

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<span class="mw-page-title-main">ACER2</span> Ceramidase enzyme

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<span class="mw-page-title-main">APBB1IP</span>

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References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000204147 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. 1 2 Avramopoulos D, Wang R, Valle D, Fallin MD, Bassett SS (April 2007). "A novel gene derived from a segmental duplication shows perturbed expression in Alzheimer's disease". Neurogenetics. 8 (2): 111–20. doi:10.1007/s10048-007-0081-5. PMID   17334805. S2CID   20156514.
  4. Deloukas P, Earthrowl ME, Grafham DV, et al. (May 2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. Bibcode:2004Natur.429..375D. doi: 10.1038/nature02462 . PMID   15164054.

Further reading