alpha-glucuronidase | |||||||||
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Identifiers | |||||||||
EC no. | 3.2.1.139 | ||||||||
CAS no. | 37259-81-7 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / QuickGO | ||||||||
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For beta-glucuronidase, see Beta-glucuronidase
In enzymology, an alpha-glucuronidase (EC 3.2.1.139) is an enzyme that catalyzes the chemical reaction
Thus, the two substrates of this enzyme are alpha-D-glucuronoside and H2O, whereas its two products are alcohol and D-glucuronate.
This enzyme belongs to the family of hydrolases, to be specific those glycosidases that hydrolyse O- and S-glycosyl compounds. The systematic name of this enzyme class is alpha-D-glucosiduronate glucuronohydrolase. This enzyme is also called alpha-glucosiduronase.
As of late 2007, 13 structures have been solved for this class of enzymes, with PDB accession codes 1GQI, 1GQJ, 1GQK, 1GQL, 1H41, 1K9D, 1K9E, 1K9F, 1L8N, 1MQP, 1MQQ, 1MQR, and 1VJT.
β-Glucuronidases are members of the glycosidase family of enzymes that catalyze breakdown of complex carbohydrates. Human β-glucuronidase is a type of glucuronidase that catalyzes hydrolysis of β-D-glucuronic acid residues from the non-reducing end of mucopolysaccharides such as heparan sulfate. Human β-glucuronidase is located in the lysosome. In the gut, brush border β-glucuronidase converts conjugated bilirubin to the unconjugated form for reabsorption. β-Glucuronidase is also present in breast milk, which contributes to neonatal jaundice. The protein is encoded by the GUSB gene in humans and by the uidA gene in bacteria.
Heparosan-N-sulfate-glucuronate 5-epimerase is an enzyme with systematic name poly( -beta-D-glucuronosyl- -N-sulfo-alpha-D-glucosaminyl) glucurono-5-epimerase. This enzyme catalyses the following chemical reaction
UDP-glucose 6-dehydrogenase is a cytosolic enzyme that in humans is encoded by the UGDH gene.
In enzymology, a haloalkane dehalogenase (EC 3.8.1.5) is an enzyme that catalyzes the chemical reaction
In enzymology, a beta-primeverosidase (EC 3.2.1.149) is an enzyme that catalyzes the chemical reaction
The enzyme glucuronosyl-disulfoglucosamine glucuronidase (EC 3.2.1.56) catalyzes the following chemical reaction:
In enzymology, a glycyrrhizinate β-glucuronidase (EC 3.2.1.128) is an enzyme that catalyzes the chemical reaction
In enzymology, a mucinaminylserine mucinaminidase (EC 3.2.1.110) is an enzyme that catalyzes the chemical reaction
In enzymology, a xyloglucan-specific exo-beta-1,4-glucanase (EC 3.2.1.155) is an enzyme that catalyzes the chemical reaction
In enzymology, a galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase is an enzyme that catalyzes the chemical reaction
In enzymology, a luteolin-7-O-diglucuronide 4'-O-glucuronosyltransferase is an enzyme that catalyzes the chemical reaction
In enzymology, a luteolin-7-O-glucuronide 2"-O-glucuronosyltransferase is an enzyme that catalyzes the chemical reaction
In enzymology, a N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase is an enzyme that catalyzes the chemical reaction
In enzymology, a N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase is an enzyme that catalyzes the chemical reaction
In enzymology, a glucuronate-1-phosphate uridylyltransferase is an enzyme that catalyzes the chemical reaction
In enzymology, a glucuronokinase is an enzyme that catalyzes the chemical reaction
Baicalin-beta-D-glucuronidase (EC 3.2.1.167, baicalinase) is an enzyme with systematic name 5,6,7-trihydroxyflavone-7-O-beta-D-glucupyranosiduronate glucuronosylhydrolase. This enzyme catalyses the following chemical reaction
Unsaturated rhamnogalacturonyl hydrolase (EC 3.2.1.172, YteR, YesR) is an enzyme with systematic name 2-O-(4-deoxy-beta-L-threo-hex-4-enopyranuronosyl)-alpha-L-rhamnopyranose hydrolase. This enzyme catalyses the following chemical reaction
Gellan tetrasaccharide unsaturated glucuronyl hydrolase (EC 3.2.1.179, UGL, unsaturated glucuronyl hydrolase) is an enzyme with systematic name beta-D-4-deoxy-Delta4-GlcAp-(1->4)-beta-D-Glcp-(1->4)-alpha-L-Rhap-(1->3)-beta-D-Glcp beta-D-4-deoxy-Delta4-GlcAp hydrolase. This enzyme catalyses the following chemical reaction
Luteolin-7-O-glucuronide is a chemical compound that is classified as a flavone.