Research into health benefits
Bifidobacterium adolescentis has been studied for its health benefits, as strains have been shown to potentially protect against or improve recovery from several diseases, including liver-related, [4] metabolic, [5] allergic airway, [6] colitis, [7] arthritis, [8] and bacterial infections. [9] Strains have also been demonstrated to possess anti-inflammatory, [10] anxiolytic, [11] antioxidant, [12] antidepressant, [13] and/or antiviral [14] activity.
In addition, B. adolescentis strains have been of interest for their ability to metabolize various compounds. This includes prebiotics such as arabinoxylan, [15] XOS, [16] and GOS. [17] Some strains of B. adolescentis are also adept at metabolizing lactose, and may reduce symptoms associated with lactose intolerance. [18] Like other bifidobacteria, B. adolescentis typically produce acetic acid and lactic acid, though the exact ratio depends on the bacterial strain, the carbohydrate being metabolized, and the growth conditions. [19] Production of short chain fatty acids and lactic acid in the colon is associated with health benefits. [20]
Bifidobacterium adolescentis contributes to the production of GABA, [21] a neurotransmitter that plays a role in reducing stress and anxiety. Some B. adolescentis strains can also synthesize B vitamins, [22] such as folic acid. [23] One strain has been shown to be bifidogenic in the GI tract. That is, the presence of one B. adolescentis strain enhances the growth of all bifidobacteria, a group that generally confers positive health benefits [24] and is important for healthy aging. [25]
Some B. adolescentis have been shown to strengthen the intestinal barrier [26] that is important in preventing pathogenic bacteria and toxins from traveling from the gut lumen into the body. Another study suggested the opposite effect: an undefined B. adolescentis strain was observed to disrupt gut barrier functions in colonic epithelial cell cultures. [27]
Multiple probiotics are marked as containing B. adolescentis, however there are a limited number of commercially available strains (PRL2019, [21] iVS‑1 [18] [26] ) with published scientific studies supporting their health claims.
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