| Brassaiopsis glomerulata | |
|---|---|
Scientific classification  | |
| Kingdom: | Plantae |
| Clade: | Tracheophytes |
| Clade: | Angiosperms |
| Clade: | Eudicots |
| Clade: | Asterids |
| Order: | Apiales |
| Family: | Araliaceae |
| Genus: | Brassaiopsis |
| Species: | B. glomerulata |
| Binomial name | |
| Brassaiopsis glomerulata | |
Brassaiopsis glomerulata is a species of shrub in the family Araliaceae. Extracts are sold as bodybuilding supplements based on the assumption that aromatase inhibitors present in the plant [2] might have effects in humans.
The Araliaceae are a family of flowering plants composed of about 43 genera and around 1500 species consisting of primarily woody plants and some herbaceous plants commonly called the ginseng family. The morphology of Araliaceae varies widely, but it is predominantly distinguishable based on its woody habit, tropical distribution, and the presence of simple umbels.
Anastrozole, sold under the brand name Arimidex among others, is an antiestrogenic medication used in addition to other treatments for breast cancer. Specifically it is used for hormone receptor-positive breast cancer. It has also been used to prevent breast cancer in those at high risk. It is taken by mouth.
Aromatase, also called estrogen synthetase or estrogen synthase, is an enzyme responsible for a key step in the biosynthesis of estrogens. It is CYP19A1, a member of the cytochrome P450 superfamily, which are monooxygenases that catalyze many reactions involved in steroidogenesis. In particular, aromatase is responsible for the aromatization of androgens into estrogens. The enzyme aromatase can be found in many tissues including gonads, brain, adipose tissue, placenta, blood vessels, skin, and bone, as well as in tissue of endometriosis, uterine fibroids, breast cancer, and endometrial cancer. It is an important factor in sexual development.
Fertility medications, also known as fertility drugs, are medications which enhance reproductive fertility. For women, fertility medication is used to stimulate follicle development of the ovary. There are very few fertility medication options available for men.
Aromatase inhibitors (AIs) are a class of drugs used in the treatment of breast cancer in postmenopausal women and in men, and gynecomastia in men. They may also be used off-label to reduce estrogen conversion when supplementing testosterone exogenously. They may also be used for chemoprevention in women at high risk for breast cancer.
Thuja standishii is a species of thuja, an evergreen coniferous tree in the cypress family Cupressaceae. It is native to southern Japan, where it occurs on the islands of Honshū and Shikoku. It is a medium-sized tree, reaching 20–35 m tall and with a trunk up to 1 m diameter.
Letrozole, sold under the brand name Femara among others, is an aromatase inhibitor medication that is used in the treatment of breast cancer for post-menopausal women.
Brassaiopsis is a genus of shrubs in the family Araliaceae. There are about 45 species, distributed in Asia from the Himalaya through China, Vietnam, Thailand to Indonesia.
Brassaiopsis acuminata is a species of plant in the family Araliaceae. It is endemic to China.
Brassaiopsis simplex is a species of plant in the family Araliaceae. It is a tree endemic to Peninsular Malaysia. It is threatened by habitat loss.
Nuxia glomerulata is a species of plant in the Stilbaceae family. It is endemic to South Africa, where it has a restricted range between Pretoria and Zeerust. It resembles Nuxia congesta but the leaves are more elliptic, leathery and glabrous. It is threatened by habitat loss.
Polyscias scopoliae is a species of plant in the family Araliaceae. It is endemic to New Caledonia.
Atamestane, also known as metandroden, as well as 1-methylandrosta-1,4-diene-3,17-dione, is a steroidal aromatase inhibitor that was studied in the treatment of cancer. It blocks the production of estrogen in the body. The drug is selective, competitive, and irreversible in its inhibition of aromatase.
Rogletimide, also known as pyridoglutethimide, is a medication which was never marketed. It is related in chemical structure to the sedative/hypnotic drug glutethimide, but instead has pharmacological activity as a selective aromatase inhibitor similar to the related drug aminoglutethimide and has no significant sedative-hypnotic effect. This makes it potentially useful in the treatment of breast cancer, and with fewer side effects than aminoglutethimide, but its lower potency caused it to be unsuccessful in clinical trials.
Steroidal aromatase inhibitors are a class of drugs that are mostly used for treating breast cancer in postmenopausal women. High levels of estrogen in breast tissue increases the risk of developing breast cancer and the enzyme aromatase is considered to be a good therapeutic target when treating breast cancer due to it being involved in the final step of estrogen biosynthetic pathway and also its inhibition will not affect production of other steroids. Aromatase Inhibitors are classified into two categories based on their structure, nonsteroidal and steroidal; the latter resemble the structure of androstenedione. Steroidal aromatase inhibitors irreversibly inhibit the enzyme by binding covalently to the binding site of aromatase so the substrate cannot access it.
Non-Steroidal Aromatase Inhibitors (NSAIs) are one of two categories of aromatase inhibitors (AIs). AIs are divided into two categories, steroidal aromatase inhibitors and non-steroidal aromatase inhibitors that is based on their mechanism of action and structure. NSAIs are mainly used to treat breast cancer in women. NSAIs binding is a reversible process where NSAIs binds to the aromatase enzyme through non-covalent interactions. When aromatase inhibitors (AIs) are used to treat breast cancer the main target is the aromatase enzyme which is responsible for the high estrogen level.
Neoguarea glomerulata is a species of flowering plant in the family Meliaceae. It is a tree or shrub native to west-central tropical Africa, ranging from southern Nigeria through Cameroon, Equatorial Guinea, Gabon, Republic of the Congo, and Democratic Republic of the Congo. It is the sole species in genus Neoguarea. It grows in lowland Guineo-Congolian rainforest.
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