Calmodulin-lysine N-methyltransferase

Last updated
calmodulin-lysine N-methyltransferase
Identifiers
EC no. 2.1.1.60
CAS no. 75603-20-2
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / QuickGO
Search
PMC articles
PubMed articles
NCBI proteins

In enzymology, a calmodulin-lysine N-methyltransferase (EC 2.1.1.60) is an enzyme that catalyzes the chemical reaction

S-adenosyl-L-methionine + calmodulin L-lysine S-adenosyl-L-homocysteine + calmodulin N6-methyl-L-lysine

Thus, the two substrates of this enzyme are S-adenosyl methionine and calmodulin L-lysine, whereas its two products are S-adenosylhomocysteine and calmodulin N6-methyl-L-lysine.

This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:calmodulin-L-lysine N6-methyltransferase. Other names in common use include S-adenosylmethionine:calmodulin (lysine) N-methyltransferase, and S-adenosyl-L-methionine:calmodulin-L-lysine 6-N-methyltransferase. This enzyme participates in lysine degradation.

Related Research Articles

<span class="mw-page-title-main">Methyltransferase</span> Group of methylating enzymes

Methyltransferases are a large group of enzymes that all methylate their substrates but can be split into several subclasses based on their structural features. The most common class of methyltransferases is class I, all of which contain a Rossmann fold for binding S-Adenosyl methionine (SAM). Class II methyltransferases contain a SET domain, which are exemplified by SET domain histone methyltransferases, and class III methyltransferases, which are membrane associated. Methyltransferases can also be grouped as different types utilizing different substrates in methyl transfer reactions. These types include protein methyltransferases, DNA/RNA methyltransferases, natural product methyltransferases, and non-SAM dependent methyltransferases. SAM is the classical methyl donor for methyltransferases, however, examples of other methyl donors are seen in nature. The general mechanism for methyl transfer is a SN2-like nucleophilic attack where the methionine sulfur serves as the leaving group and the methyl group attached to it acts as the electrophile that transfers the methyl group to the enzyme substrate. SAM is converted to S-Adenosyl homocysteine (SAH) during this process. The breaking of the SAM-methyl bond and the formation of the substrate-methyl bond happen nearly simultaneously. These enzymatic reactions are found in many pathways and are implicated in genetic diseases, cancer, and metabolic diseases. Another type of methyl transfer is the radical S-Adenosyl methionine (SAM) which is the methylation of unactivated carbon atoms in primary metabolites, proteins, lipids, and RNA.

In enzymology, a 3'-hydroxy-N-methyl-(S)-coclaurine 4'-O-methyltransferase is an enzyme that catalyzes the chemical reaction

In enzymology, a [cytochrome c]-arginine N-methyltransferase is an enzyme that catalyzes the chemical reaction

In enzymology, a [cytochrome c]-lysine N-methyltransferase (EC 2.1.1.59) is an enzyme that catalyzes the chemical reaction

In enzymology, a fatty-acid O-methyltransferase is an enzyme that catalyzes the chemical reaction

In enzymology, an inositol 4-methyltransferase is an enzyme that catalyzes the chemical reaction

In enzymology, a methionine S-methyltransferase is an enzyme that catalyzes the chemical reaction

In enzymology, a mRNA (2'-O-methyladenosine-N6-)-methyltransferase is an enzyme that catalyzes the chemical reaction

In enzymology, a [myelin basic protein]-arginine N-methyltransferase is an enzyme that catalyzes the chemical reaction

In enzymology, a protein-histidine N-methyltransferase is an enzyme that catalyzes the chemical reaction

In enzymology, a [ribulose-bisphosphate carboxylase]-lysine N-methyltransferase (EC 2.1.1.127) is an enzyme that catalyzes the chemical reaction

In enzymology, a rRNA (adenine-N6-)-methyltransferase (EC 2.1.1.48) is an enzyme that catalyzes the chemical reaction

In enzymology, a (S)-tetrahydroprotoberberine N-methyltransferase is an enzyme that catalyzes the chemical reaction

In enzymology, a tRNA (adenine-N6-)-methyltransferase (EC 2.1.1.55) is an enzyme that catalyzes the chemical reaction

<span class="mw-page-title-main">KMT5A</span> Protein-coding gene in humans

N-lysine methyltransferase KMT5A is an enzyme that in humans is encoded by the KMT5A gene. The enzyme is a histone methyltransferase, SET domain-containing and lysine-specific. The enzyme transfers one methyl group to histone H4 lysine residue at position 20. S-Adenosyl methionine (SAM) is both the cofactor and the methyl group donor. The lysine residue is converted to N6-methyllysine residue.

Bisphosphate may refer to:

Methyl halide transferase is an enzyme with systematic name S-adenosylmethionine:iodide methyltransferase. This enzyme catalyses the following chemical reaction

23S rRNA (adenine1618-N6)-methyltransferase (EC 2.1.1.181, rRNA large subunit methyltransferase F, YbiN protein, rlmF (gene), m6A1618 methyltransferase) is an enzyme with systematic name S-adenosyl-L-methionine:23S rRNA (adenine1618-N6)-methyltransferase. This enzyme catalyses the following chemical reaction

Protein N-terminal methyltransferase is an enzyme with systematic name S-adenosyl-L-methionine:N-terminal-(A,P,S)PK-(protein) methyltransferase. This enzyme catalyses the following chemical reaction

[Fructose-bisphosphate aldolase]-lysine N-methyltransferase (EC 2.1.1.259) is an enzyme that catalyses the following chemical reaction

References


    This page is based on this Wikipedia article
    Text is available under the CC BY-SA 4.0 license; additional terms may apply.
    Images, videos and audio are available under their respective licenses.