N-acetylornithine carbamoyltransferase

N-acetylornithine carbamoyltransferase
Identifiers
EC no.	2.1.3.9
CAS no.	890853-54-0
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, a N-acetylornithine carbamoyltransferase (EC 2.1.3.9) is an enzyme that catalyzes the chemical reaction: ^{[1] [2]}

carbamoyl phosphate

+

 

N(2)-acetyl-L-ornithine

 

 

H₂PO−4

 

H₂PO−4

 

N-acetyl-L-citrulline

The enzyme converts N(2)-acetyl-L-ornithine to N-acetyl-L-citrulline by transferring a carbamoyl group from carbamoyl phosphate.

This enzyme belongs to the family of transferases that transfer one-carbon groups, specifically the carboxy- and carbamoyltransferases. The systematic name of this enzyme class is carbamoyl-phosphate:N2-acetyl-L-ornithine carbamoyltransferase. Other names in common use include acetylornithine transcarbamylase, N-acetylornithine transcarbamylase, AOTC, and carbamoyl-phosphate:2-N-acetyl-L-ornithine carbamoyltransferase.

Structural studies

As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes 2G65, 2G68, 2G6A, and 2G6C.

References

1. Enzyme 2.1.3.9 at KEGG Pathway Database.
2. Shi D, Morizono H, Yu X, Roth L, Caldovic L, Allewell NM, Malamy MH, Tuchman M (April 2005). "Crystal structure of N-acetylornithine transcarbamylase from Xanthomonas campestris: a novel enzyme in a new arginine biosynthetic pathway found in several eubacteria". The Journal of Biological Chemistry. 280 (15): 14366–9. doi: 10.1074/jbc.C500005200 . PMID   15731101.