Chicken anemia virus

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Chicken anemia virus
Virus classification Red Pencil Icon.png
(unranked): Virus
Realm: incertae sedis
Kingdom: incertae sedis
Phylum: incertae sedis
Class: incertae sedis
Order: incertae sedis
Family: Anelloviridae
Genus: Gyrovirus
Species:
Chicken anemia virus
Synonyms

Chicken anaemia virus

Chicken anemia virus Chicken anemia virus.jpg
Chicken anemia virus

Chicken anemia virus, or CAV, is currently a member of the Anelloviridae family which is found worldwide. [1] The virus only affects chickens. [2] CAV is a non-enveloped icosahedral single stranded DNA virus, [3] which causes bone marrow atrophy, anemia, and severe immunosuppression. Clinical signs of CAV infection are predominantly found in young chicks due to vertical transmission from the breeder hens whose maternal antibodies have not yet formed following exposure. Clinical disease is rare today because of the widespread practice of vaccinating breeders, but the subclinical form of the disease—which normally affects birds more than two weeks of age following horizontal transmission of the virus via the fecal–oral route—is ubiquitous. The virus is very resistant in the environment, making elimination very difficult.

Contents

The disease and virus have many names including chicken anemia, blue wing disease, anemia dermatitis syndrome, chicken/avian infectious anemia, hemorrhagic aplastic anemia syndrome, infectious chicken anemia, chicken infectious anemia virus, and chicken anemia agent.[ citation needed ] When this virus was first discovered in 1979, it was named chicken anemia agent. [1]

Clinical signs

Clinical signs only occur in chicks less than three weeks of age. [4] During outbreaks of CAV, up to 10% of chicks can die. [5] Signs include a pale comb, wattle, eyelids, legs and carcass, anorexia, weakness, stunting, unthriftiness, weight loss, cyanosis, petechiation and ecchymoses, lethargy, and sudden death. Neurological signs include dullness, depression and paresis.

In older chickens, an infection with no apparent symptoms may cause reduced growth rates due to a poor feed conversion ratio. [2]

Pathogenesis

CAV infects precursor T cells in the thymus and hematopoietic stem cells in the bone marrow, [2] causing destruction of these cells via apoptosis. [4] This reduces the production of red blood cells (RBC) and white blood cells (WBC), leading to severe immunosuppression and anemia. [2]

Diagnosis

A presumptive diagnosis can be made based on the clinical signs and a low hematocrit reading, e.g. below 27%. Virus isolation, increased antibody titres, immunoperoxidase staining, ELISA, PCR or indirect immunofluorescence can be used to confirm the presence of the virus. Post mortem findings show significant atrophy of the lymphoid organs, hemorrhage throughout the tissues, and pale watery bone marrow.

Treatment and control

There is no specific treatment for infected birds. Culling of infected birds is normally performed in infected commercial flocks. Birds that have been infected develop immunity to the virus.

Vertical spread of the disease can be controlled by the vaccination of breeding hens with both live attenuated and wild vaccines. These vaccines reduce the vertical transmission rate. The vaccine has the ATCvet code QI01AD04 ( WHO ). Appropriate hygiene and biosecurity measures may be employed to control the disease.

Related Research Articles

<span class="mw-page-title-main">Infection</span> Invasion of an organisms body by pathogenic agents

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<span class="mw-page-title-main">Dengue fever</span> Tropical disease caused by the dengue virus, transmitted by mosquito

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Aplastic anemia is a disease in which the body fails to produce blood cells in sufficient numbers. Blood cells are produced in the bone marrow by stem cells that reside there. Aplastic anemia causes a deficiency of all blood cell types: red blood cells, white blood cells, and platelets.

<span class="mw-page-title-main">Respiratory syncytial virus</span> Species of a virus

Respiratory syncytial virus (RSV), also called human respiratory syncytial virus (hRSV) and human orthopneumovirus, is a common, contagious airborne virus that causes infections of the respiratory tract. It is a negative-sense, single-stranded RNA virus. Its name is derived from the large cells known as syncytia that form when infected cells fuse.

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<span class="mw-page-title-main">Parvovirus B19</span> Human virus

Primate erythroparvovirus 1, generally referred to as B19 virus(B19V),parvovirus B19 or sometimes erythrovirus B19, is the first known human virus in the family Parvoviridae, genus Erythroparvovirus; it measures only 23–26 nm in diameter. The name is derived from Latin, parvum meaning small, reflecting the fact that B19 ranks among the smallest DNA viruses. B19 virus is most known for causing disease in the pediatric population; however, it can also affect adults. It is the classic cause of the childhood rash called fifth disease or erythema infectiosum, or "slapped cheek syndrome".

<i>Feline leukemia virus</i> Species of virus

Feline leukemia virus (FeLV) is a retrovirus that infects cats. FeLV can be transmitted from infected cats when the transfer of saliva or nasal secretions is involved. If not defeated by the animal's immune system, the virus weakens the cat's immune system, which can lead to diseases which can be lethal. Because FeLV is cat-to-cat contagious, FeLV+ cats should only live with other FeLV+ cats.

Infectious salmon anemia (ISA) is a viral disease of Atlantic salmon caused by Salmon isavirus. It affects fish farms in Canada, Norway, Scotland and Chile, causing severe losses to infected farms. ISA has been a World Organisation for Animal Health notifiable disease since 1990. In the EU, it is classified as a non-exotic disease, and is monitored by the European Community Reference Laboratory for Fish Diseases.

<span class="mw-page-title-main">Equine infectious anemia</span> Species of virus

Equine infectious anemia or equine infectious anaemia (EIA), also known by horsemen as swamp fever, is a horse disease caused by a retrovirus and transmitted by bloodsucking insects. The virus (EIAV) is endemic in the Americas, parts of Europe, the Middle and Far East, Russia, and South Africa. The virus is a lentivirus, like human immunodeficiency virus (HIV). Like HIV, EIA can be transmitted through blood, milk, and body secretions. Transmission is primarily through biting flies, such as the horse-fly and deer-fly. The virus survives up to 4 hours in the vector. Contaminated surgical equipment and recycled needles and syringes, and bits can transmit the disease. Mares can transmit the disease to their foals via the placenta. The risk of transmitting the disease is greatest when an infected horse is ill, as the blood levels of the virus are then highest.

Poultry diseases occur in poultry, which are domesticated birds kept for their meat, eggs or feathers. Poultry species include the chicken, turkey, duck, goose and ostrich.

<span class="mw-page-title-main">Infectious bursal disease</span> Viral disease of poultry

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Marek's disease is a highly contagious viral neoplastic disease in chickens. It is named after József Marek, a Hungarian veterinarian who described it in 1907. Marek's disease is caused by an alphaherpesvirus known as "Marek's disease virus" (MDV) or Gallid alphaherpesvirus 2 (GaHV-2). The disease is characterized by the presence of T cell lymphoma as well as infiltration of nerves and organs by lymphocytes. Viruses related to MDV appear to be benign and can be used as vaccine strains to prevent Marek's disease. For example, the related herpesvirus found in turkeys (HVT), causes no apparent disease in the birds, and continues to be used as a vaccine strain for prevention of Marek's disease.

Aviadenoviruses are adenoviruses that affect birds—particularly chickens, ducks, geese, turkeys and pheasants. There are 15 species in this genus. Viruses in this genus cause specific disease syndromes such as Quail Bronchitis (QB), Egg Drop Syndrome (EDS), Haemorrhagic Enteritis (HE), Pheasant Marble Spleen Disease (MSD), and Inclusion Body Hepatitis (IBH). Avian adenoviruses have a worldwide distribution and it is common to find multiple species on a single farm. The most common serogroups are serogroup 1, 2 and 3.

Bovine alphaherpesvirus 1 (BoHV-1) is a virus of the family Herpesviridae and the subfamily Alphaherpesvirinae, known to cause several diseases worldwide in cattle, including rhinotracheitis, vaginitis, balanoposthitis, abortion, conjunctivitis, and enteritis. BoHV-1 is also a contributing factor in shipping fever, also known as bovine respiratory disease (BRD). It is spread horizontally through sexual contact, artificial insemination, and aerosol transmission and it may also be transmitted vertically across the placenta. BoHV-1 can cause both clinical and subclinical infections, depending on the virulence of the strain. Although these symptoms are mainly non-life-threatening it is an economically important disease as infection may cause a drop in production and affect trade restrictions. Like other herpesviruses, BoHV-1 causes a lifelong latent infection and sporadic shedding of the virus. The sciatic nerve and trigeminal nerve are the sites of latency. A reactivated latent carrier is normally the source of infection in a herd. The clinical signs displayed are dependent on the virulence of the strain. There is a vaccine available which reduces the severity and incidence of disease. Some countries in Europe have successfully eradicated the disease by applying a strict culling policy.

<span class="mw-page-title-main">Medical microbiology</span> Branch of medical science

Medical microbiology, the large subset of microbiology that is applied to medicine, is a branch of medical science concerned with the prevention, diagnosis and treatment of infectious diseases. In addition, this field of science studies various clinical applications of microbes for the improvement of health. There are four kinds of microorganisms that cause infectious disease: bacteria, fungi, parasites and viruses, and one type of infectious protein called prion.

Gyrovirus is a genus of viruses, in the family Anelloviridae. Until 2011, chicken anemia virus was the only Gyrovirus identified, but since then gyroviruses have also been identified in humans. Diseases associated with this genus include: chicken infectious anemia, which is associated with depletion of cortical thymocytes and erythroblastoid cells.

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The avian immune system is the system of biological structures and cellular processes that protects birds from disease.

<span class="mw-page-title-main">Egg drop syndrome</span> Viral disease of birds

Egg drop syndrome '76 is a viral disease that affects birds, notably chickens, ducks, geese and swans. It is characterised by a sudden drop in production of eggs as well as its eggshell quality in apparent healthy laying birds.

<i>West Nile virus</i> Species of flavivirus causing West Nile fever

West Nile virus (WNV) is a single-stranded RNA virus that causes West Nile fever. It is a member of the family Flaviviridae, from the genus Flavivirus, which also contains the Zika virus, dengue virus, and yellow fever virus. The virus is primarily transmitted by mosquitoes, mostly species of Culex. The primary hosts of WNV are birds, so that the virus remains within a "bird–mosquito–bird" transmission cycle. The virus is genetically related to the Japanese encephalitis family of viruses.

References

  1. 1 2 Schat, KA (2009). "Chicken anemia virus". Current Topics in Microbiology and Immunology. 331: 151–83. doi:10.1007/978-3-540-70972-5_10. ISBN   978-3-540-70971-8. PMID   19230563.
  2. 1 2 3 4 Markey, B; Leonard, F; Archambault, M; Cullinane, A; Maguire, D (2013). "Chapter 46: Circoviridae". Clinical veterinary microbiology (2nd ed.). Elsevier Health Sciences. pp. 547–550. ISBN   9780702055881.
  3. Fang, L; Li, Y; Wang, Y; Fu, J; Cui, S; Li, X; Chang, S; Zhao, P (2017). "Genetic Analysis of Two Chicken Infectious Anemia Virus Variants-Related Gyrovirus in Stray Mice and Dogs: The First Report in China, 2015". BioMed Research International. 2017: 6707868. doi: 10.1155/2017/6707868 . PMC   5343220 . PMID   28326326.
  4. 1 2 Miller, MM; Jarosinski, KW; Schat, KA (March 2005). "Positive and negative regulation of chicken anemia virus transcription". Journal of Virology. 79 (5): 2859–68. doi:10.1128/JVI.79.5.2859-2868.2005. PMC   548473 . PMID   15709005.
  5. Quinn, PJ; Markey, BK; Leonard, FC; Fitzpatrick, ES; Fanning, S (2015). "Chicken anaemia virus infection". Concise Review of Veterinary Microbiology (2nd ed.). John Wiley & Sons. p. 146. ISBN   9781118802687.

2. Chicken Anaemia Virus Disease, expert reviewed and published by Wikivet, accessed 30/08/2011.