D-glutamate oxidase

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D-glutamate oxidase
D-glutamate oxidase
Identifiers
EC no.	1.4.3.7
CAS no.	37255-41-7
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
PMC
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PubMed	articles
NCBI	proteins

Last updated August 20, 2025

In enzymology, a D-glutamate oxidase (EC 1.4.3.7) is an enzyme that catalyzes the chemical reaction

D-glutamate + H₂O + O₂ ⇌ 2-oxoglutarate + NH₃ + H₂O₂

The 3 substrates of this enzyme are D-glutamate, H₂O, and O₂, whereas its 3 products are 2-oxoglutarate, NH₃, and H₂O₂.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH₂ group of donors with oxygen as acceptor. The systematic name of this enzyme class is D-glutamate:oxygen oxidoreductase (deaminating). Other names in common use include D-glutamic oxidase, and D-glutamic acid oxidase. This enzyme participates in d-glutamine and d-glutamate metabolism.

References

ROCCA E, GHIRETTI F (1958). "Purification and properties of D-glutamic acid oxidase from Octopus vulgaris Lam". Arch. Biochem. Biophys. 77 (2): 336–49. doi:10.1016/0003-9861(58)90081-X. PMID 13583997.
Urich K (1968). "[D-Glutamate oxidase from the antennal gland of the crayfish Oronectes limosus: purification and characterization]". Z. Naturforsch. B. 23 (11): 1508–11. doi: 10.1515/znb-1968-1114 . PMID 4387700.

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v t e CH-NH₂ oxidoreductases (EC 1.4) - primarily amino acid oxidoreductases
1.4.1: NAD/NADP acceptor	Glutamate dehydrogenase GLUD1 GLUD2 Glutamate synthase (NADPH)
1.4.3: oxygen acceptor	D-amino acid oxidase Amine oxidase (Copper-containing (Lysyl Diamine Primary-amine)) (Flavin-containing (Monoamine)))
1.4.4: disulfide acceptor	Glycine cleavage system
1.4.99: other acceptors	D-amino acid dehydrogenase Amine dehydrogenase

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)