Dectaflur

Last updated
Dectaflur
Dectaflur Structural Formula V.1.svg
Clinical data
Routes of
administration 		Topical (gel, solution)
ATC code
  • none
Legal status
Legal status
Identifiers
  • 9-Octadeceylamine hydrofluoride
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard 100.297.781 OOjs UI icon edit-ltr-progressive.svg
Chemical and physical data
Formula C18H38FN
Molar mass 287.507 g·mol−1
3D model (JSmol)
  • [F-].C(=C/CCCCCCCC)\CCCCCCCC[NH3+]
  • InChI=1S/C18H37N.FH/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19;/h9-10H,2-8,11-19H2,1H3;1H/b10-9+;
  • Key:QGSCPWWHMSCFOV-RRABGKBLSA-N

Dectaflur (INN) is a fluoride-containing substance used for the prevention and treatment of dental caries, sensitive teeth, and the refluoridation of damaged tooth enamel, typically in combination with olaflur. [1]

Contents

Chemistry and mechanism of action

Dectaflur consists of oleyl amine (the amine corresponding to oleyl alcohol) and hydrofluoric acid. Oleyl amine with its long lipophilic hydrocarbon chain has surfactant properties. It forms a film layer on the surface of teeth, which facilitates incorporation of fluoride into the top layers of the enamel, reaching a depth of only a few nanometers. The precise mechanism of action is unknown. [2]

Side effects

Like other fluorides, dectaflur is toxic when overdosed over an extended period of time. Especially in children, before the development of the permanent teeth, overdosage can lead to dental fluorosis. [3]

References

  1. ↑ Haberfeld H, ed. (2009). Austria-Codex (in German) (2009/2010 ed.). Vienna: Österreichischer Apothekerverlag. Elmex Zahngel. ISBN   978-3-85200-196-8.
  2. ↑ Müller F, Zeitz C, Mantz H, Ehses KH, Soldera F, Schmauch J, et al. (December 2010). "Elemental depth profiling of fluoridated hydroxyapatite: saving your dentition by the skin of your teeth?". Langmuir. 26 (24): 18750–9. doi:10.1021/la102325e. PMID   21090577.
  3. ↑ Abanto Alvarez J, Rezende KM, Marocho SM, Alves FB, Celiberti P, Ciamponi AL (February 2009). "Dental fluorosis: exposure, prevention and management". Medicina Oral, Patologia Oral y Cirugia Bucal. 14 (2): E103-7. PMID   19179949.
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