Erythromycin 3''-O-methyltransferase

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Erythromycin 3''-O-methyltransferase
Identifiers
EC no. 2.1.1.254
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Erythromycin 3''-O-methyltransferase (EC 2.1.1.254, EryG) is an enzyme with systematic name S-adenosyl-L-methionine:erythromycin C 3''-O-methyltransferase. [1] [2] This enzyme catalyses the following chemical reaction

(1) S-adenosyl-L-methionine + erythromycin C S-adenosyl-L-homocysteine + erythromycin A
(2) S-adenosyl-L-methionine + erythromycin D S-adenosyl-L-homocysteine + erythromycin B

The enzyme methylates the 3 position of the mycarosyl moiety of erythromycin C.

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References

  1. ↑ Paulus TJ, Tuan JS, Luebke VE, Maine GT, DeWitt JP, Katz L (May 1990). "Mutation and cloning of eryG, the structural gene for erythromycin O-methyltransferase from Saccharopolyspora erythraea, and expression of eryG in Escherichia coli". Journal of Bacteriology. 172 (5): 2541–6. doi:10.1128/jb.172.5.2541-2546.1990. PMC   208895 . PMID   2185226.
  2. ↑ Summers RG, Donadio S, Staver MJ, Wendt-Pienkowski E, Hutchinson CR, Katz L (October 1997). "Sequencing and mutagenesis of genes from the erythromycin biosynthetic gene cluster of Saccharopolyspora erythraea that are involved in L-mycarose and D-desosamine production". Microbiology. 143 (10): 3251–62. doi: 10.1099/00221287-143-10-3251 . PMID   9353926.


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