State Road 50 runs across the center of the U.S. state of Florida through Orlando, with its termini at SR 55 at Weeki Wachee and SR 5 in Titusville.
Interstate 110 (I-110) is a 6.341-mile (10.205 km) auxiliary route of the Interstate Highway System in Pensacola, Florida, extending north from U.S. Highway 98 to Interstate 10. I-110 carries the hidden Florida Department of Transportation designation of State Road 8A. The easternmost auxiliary route of I-10, it is also known as the Reubin O'Donovan Askew Parkway in honor of the former governor of Florida who originated in Pensacola.
State Road 30A (SR 30A) is a Florida Department of Transportation designation shared by four alternate routings of SR 30 in the Florida panhandle. Two segments have SR 30A signage; the other two do not as they are segments of U.S. Route 98 (US 98). Three of the four SR 30A segments are next to the shore of the Gulf of Mexico for most of their length.
State Road 78 is the Florida Department of Transportation designation of the highway that historically extended from Pine Island Center on the Gulf Coast of Florida to the northern tip of Lake Okeechobee. In the 1980s, two segments of the route were removed from state maintenance to county maintenance. More recently, SR 78 signs were removed from the four-mile-long stretch of US 27/SR 25 that was once a concurrency. All three sections are signed east–west, even though the easternmost section is actually a north–south route.
State Road 44 is an east–west state highway in the U.S. state of Florida. It runs from Crystal River on the Gulf of Mexico east to New Smyrna Beach on the Atlantic Ocean, passing through Inverness, Wildwood, Leesburg and DeLand.
State Road 727 (SR 727) is a 6.755-mile-long (10.871 km) state highway in the Pensacola metropolitan area. It is one of four "misnumbered" state road 7xx highways in the Pensacola area. It is locally known as West Fairfield Drive and South Fairfield Drive. Its southern terminus is at an intersection with SR 292. Its northern terminus is an intersection with SR 295 in West Pensacola. From the eastern terminus, Fairfield Drive continues eastward with the SR 295 designation until SR 289 in Pensacola. Until the mid-1990s, the route was designated State Road 289A.
Interstate 10 (I-10) runs for 362 miles (583 km) in Florida as the easternmost section of an east-west Interstate Highway in the southern United States. It is also the eastern end of one of three coast-to-coast Interstates, along with I-80 and I-90. The highway runs east from the Alabama border, traveling through the Panhandle of Florida, serving the major cities of Pensacola, Tallahassee, Lake City, ending at Jacksonville, and carries the hidden Florida Department of Transportation (FDOT) designation of State Road 8 (SR 8).
State Road 292 is a major thoroughfare in the Pensacola, Florida metropolitan area. Locally, it is known as Pace Boulevard, Barrancas Avenue, Gulf Beach Highway, Sorrento Road, and Perdido Key Drive.
State Road 173, locally known as Blue Angel Parkway, is a major thoroughfare in the Pensacola, Florida metropolitan area. SR 173 has its southern terminus at the western entrance to NAS Pensacola, and runs south–north through West Pensacola to its northern terminus at State Road 297.
Interstate 10 (I-10) is a part of the Interstate Highway System that runs from Santa Monica, California, to Jacksonville, Florida. In Alabama, the Interstate Highway runs 66.269 miles (106.650 km) from the Mississippi state line near Grand Bay east to the Florida state line at the Perdido River. I-10 is the primary east–west highway of the Gulf Coast region of Alabama. The highway connects Mobile, the largest city in South Alabama, with Pascagoula, Mississippi, to the west and Pensacola, Florida, to the east. Within the state, the highway connects Mobile and Mobile County with the Baldwin County communities of Daphne and Fairhope. I-10 connects Mobile and Baldwin County by crossing the northern end of Mobile Bay and the southern end of the Mobile-Tensaw River Delta via the George Wallace Tunnel in Mobile and the Jubilee Parkway viaduct system between Mobile and Daphne.
State Road 399 is a state road in Santa Rosa County, Florida. Although it only extends 0.32 miles (0.51 km) from U.S. Route 98 (US 98) to the Bob Sikes Bridge, County Road 399 continues over the bridge, along Santa Rosa Island, and back to US 98 via the Navarre Bridge. Other segments of CR 399 also exist on the mainland.
U.S. Route 19 runs 264 miles (425 km) along Florida's west coast from an interchange with U.S. Route 41 in Memphis, Florida, south of Tampa, and continues to the Georgia border north of Monticello, Florida.
U.S. Route 90 (US 90) in the state of Florida is the northernmost east–west United States Numbered Highway in the state. US 90 passes through the county seats of all 15 counties on its course in Florida, and it is also the road upon which many of the county courthouses are located. It is never more than six miles (9.7 km) from Interstate 10 (I-10) throughout the state. It runs as a two-lane highway through most of the sparsely populated inland areas of the Florida Panhandle, widening to four lanes through and near several towns. The speed limit is 55 mph (89 km/h) for all rural points west of Monticello, and it is 60 mph (97 km/h) on all rural points beginning in Madison County to Glen St. Mary.
U.S. Route 98 is an east-west United States highway that runs 671 miles (1,080 km) from the Alabama-Florida state line to southern Florida. It is the longest US road in Florida. It was established in 1933 as a route between Pensacola and Apalachicola, and has since been extended eastward across the Florida Peninsula and westward into Mississippi. It runs along much of the Gulf Coast between Mobile, Alabama and Crystal River, Florida, including extensive sections closely following the coast eastward from the Alabama-Florida state line to St. Marks. At a length of 671 miles, US 98 is the longest numbered route in the state of Florida.
U.S. Route 301 in Florida runs from the Sarasota-Bradenton-Venice, Florida Metropolitan Statistical Area northeast to the Greater Jacksonville Metropolitan Area. The road is a spur of U.S. Route 1, which it intersects in Callahan.
State Road 289, known locally as North 9th Avenue, is a north–south major thoroughfare in Pensacola, Florida.
State Road 298, known locally as Lillian Highway, is a mostly east–west thoroughfare in Pensacola, Florida. It runs from its intersection with U.S. Highway 98 and Dog Track Road, skirting Perdido Bay on its way east to its terminus at the West Pensacola spur of SR 295. SR 298 passes under the mainline of SR 295 without an interchange. It serves as a major route through the communities of Myrtle Grove and West Pensacola.
State Road 79 is a north–south highway in the panhandle of Florida. It is a popular route for tourists to and from the Panama City Beach area. The route begins at Alabama State Route 167 at the Alabama–Florida border and runs to its southern terminus at State Road 30 in Panama City Beach, Florida. Currently, the highway is being expanded to four lanes north of Panama City to the junction with Interstate 10. SR 79 is a major hurricane evacuation route from the coastal area. It is one of few designated routes northward between Pensacola and Panama City.
There are six special routes along U.S. Route 98 and seven former routes. Most US 98 bannered routes are located in the U.S. state of Florida.
State Road 368 (SR 368) is a short state road an east–west "bypass route", locally known as 23rd Street, in and around the vicinity of Panama City, Florida. The road is entirely four-lanes wide with center left-turn lanes where available, and is divided only at its eastern terminus. No roads overlap SR 368 or vice versa.
US 98 towards Mobile, AL 
SR 392A in Panama City Beach 
US 19 / US 27 Alt. / US 98 / US 221 in Perry 
