Glycosyl hydrolases family 19 | |||||||||
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Identifiers | |||||||||
Symbol | Glyco_hydro_19 | ||||||||
Pfam | PF00182 | ||||||||
Pfam clan | CL0037 | ||||||||
InterPro | IPR000726 | ||||||||
PROSITE | PDOC00620 | ||||||||
SCOP2 | 2baa / SCOPe / SUPFAM | ||||||||
CAZy | GH19 | ||||||||
CDD | cd00325 | ||||||||
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In molecular biology, Glycoside hydrolase family 19 is a family of glycoside hydrolases EC 3.2.1., which are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different families. [1] [2] [3] This classification is available on the CAZy web site, [4] [5] and also discussed at CAZypedia, an online encyclopedia of carbohydrate active enzymes. [6] [7] y[ _]9
Glycoside hydrolase family 19 CAZY GH_19 comprises enzymes with only one known activity; chitinase (EC 3.2.1.14).
Chitinases [8] are enzymes that catalyze the hydrolysis of the beta-1,4-N-acetyl-D-glucosamine linkages in chitin polymers. Chitinases belong to glycoside hydrolase families 18 or 19. [9] Chitinases of family 19 (also known as classes IA or I and IB or II) are enzymes from plants that function in the defence against fungal and insect pathogens by destroying their chitin-containing cell wall. Class IA/I and IB/II enzymes differ in the presence (IA/I) or absence (IB/II) of a N-terminal chitin-binding domain. The catalytic domain of these enzymes consist of about 220 to 230 amino acid residues.
GH19 enzymes has a conserved sequence motif ([FHY]-G-R-G-[AP]-ζ-Q-[IL]-[ST]-[FHYW]-[HN]-[FY]-[NY], ζ= hydrophilic amino acid) in its active site. [11]
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