Glycosylceramidase

Glycosylceramidase
Identifiers
EC no.	3.2.1.62
CAS no.	9033-10-7
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

The enzyme glycosylceramidase (EC 3.2.1.62) catalyzes the following chemical reaction:

glycosyl-N-acylsphingosine + H₂O ${\displaystyle \rightleftharpoons }$N-acylsphingosine + a sugar

It belongs to the family of hydrolases, specifically those glycosidases that hydrolyse O- and S-glycosyl compounds. The systematic name of this enzyme class is glycosyl-N-acylsphingosine glycohydrolase. Other names in common use include phlorizin hydrolase, phloretin-glucosidase, glycosyl ceramide glycosylhydrolase, cerebrosidase, phloridzin β-glucosidase, lactase-phlorizin hydrolase, and phloridzin glucosidase.

References

• Leese HJ, Semenza G (1973). "On the identity between the small intestinal enzymes phlorizin hydrolase and glycosylceramidase". J. Biol. Chem. 248 (23): 8170–3. doi: 10.1016/S0021-9258(19)43209-2 . PMID   4752949.
• Lorenz-Meyer H, Blum AL, Haemmerli HP, Semenza G (1972). "A second enzyme defect in acquired lactase deficiency: lack of small-intestinal phlorizin-hydrolase". Eur. J. Clin. Invest. 2 (5): 326–31. doi:10.1111/j.1365-2362.1972.tb00658.x. PMID   5082068.
• Malathi P, Crane RK (1969). "Phlorizin hydrolase: a β-glucosidase of hamster intestinal brush border membrane". Biochim. Biophys. Acta. 173 (2): 245–56. doi:10.1016/0005-2736(69)90108-4. PMID   5774775.