Kaempferol 4'-O-methyltransferase

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Kaempferol 4'-O-methyltransferase
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EC no. 2.1.1.155
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In enzymology, a kaempferol 4'-O-methyltransferase (EC 2.1.1.155) is an enzyme that catalyzes the chemical reaction

S-adenosyl-L-methionine + kaempferol S-adenosyl-L-homocysteine + kaempferide

Thus, the two substrates of this enzyme are S-adenosyl methionine and kaempferol, whereas its two products are S-adenosylhomocysteine and kaempferide.

This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:kaempferol 4'-O-methyltransferase. Other names in common use include S-adenosyl-L-methionine:flavonoid 4'-O-methyltransferase, and F 4'-OMT.

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<span class="mw-page-title-main">Kaempferide</span> Chemical compound

Kaempferide is an O-methylated flavonol, a type of chemical compound. It can be found in Kaempferia galanga. It has been noted to inhibit pancreatic cancer growth by blockading an EGFR-related pathway.

<span class="mw-page-title-main">Isorhamnetin</span> Chemical compound

Isorhamnetin is an O-methylated flavon-ol from the class of flavonoids. A common food source of this 3'-methoxylated derivative of quercetin and its glucoside conjugates are pungent yellow or red onions, in which it is a minor pigment, quercetin-3,4'-diglucoside and quercetin-4'-glucoside and the aglycone quercetin being the major pigments. Pears, olive oil, wine and tomato sauce are rich in isorhamnetin. Others sources include the spice, herbal medicinal and psychoactive Mexican tarragon (Tagetes lucida), which is described as accumulating isorhamnetin and its 7-O-glucoside derivate. Nopal is also a good source of isorhamnetin, which can be extracted by supercritical fluid extraction assisted by enzymes.

The O-methylated flavonoids or methoxyflavonoids are flavonoids with methylations on hydroxyl groups. O-methylation has an effect on the solubility of flavonoids.

S-adenosyl-L-methionine:flavonoid 4'-O-methyltransferase may refer to:

Flavonoid 4'-O-methyltransferase is an enzyme with systematic name S-adenosyl-L-methionine:flavonoid 4'-O-methyltransferase. This enzyme catalyses the following chemical reaction

References