L-lysine oxidase

L-lysine oxidase
Identifiers
EC no.	1.4.3.14
CAS no.	70132-14-8
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, a L-lysine oxidase (EC 1.4.3.14) is an enzyme that catalyzes the chemical reaction

L-lysine + O₂ + H₂O ⇌ 6-amino-2-oxohexanoate + NH₃ + H₂O₂

The 3 substrates of this enzyme are L-lysine, O₂, and H₂O, whereas its 3 products are 6-amino-2-oxohexanoate, NH₃, and H₂O₂.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH₂ group of donors with oxygen as acceptor. The systematic name of this enzyme class is L-lysine:oxygen 2-oxidoreductase (deaminating). Other names in common use include L-lysine alpha-oxidase, and L-lysyl-alpha-oxidase. This enzyme participates in lysine degradation.

References

• Kusakabe H, Kodama K, Kuninaka A, Yoshino H, Misono H, Soda K (1980). "A new antitumor enzyme, L-lysine alpha-oxidase from Trichoderma viride. Purification and enzymological properties". J. Biol. Chem. 255 (3): 976–81. doi: 10.1016/S0021-9258(19)86128-8 . PMID   6101334.
• Lukasheva, EV; Berezov, TT (October 2002). "L-Lysine alpha-oxidase: physicochemical and biological properties". Biochemistry (Moscow). 67 (10): 1152–8. doi:10.1023/A:1020967408229. PMID   12460113.