The following people were born in, residents of, or otherwise closely associated with Charleston, South Carolina, United States (categorized by area in which each person is best known):
Matt Watson (born 1996), YouTuber, Member and Co-Founder of SuperMega
Law
James Francis Byrnes (1879–1972), U.S. Representative and Senator, Associate Justice of the Supreme Court, Secretary of State, and Governor of South Carolina
George Heriot DeReef (1869–1937), American lawyer, political candidate, civil rights leader, and businessman
Reuben Greenberg (1943–2014), the first black police chief of Charleston
J. Waites Waring (1880–1968), United States District Court for District of South Carolina judge; part of a three-judge panel that heard school desegregation case Briggs v. Elliott
Judah P. Benjamin (1811–1884), U.S. Senator from Louisiana, Confederate States Secretary of State and Attorney General
Don C. Bowen (b. 1945), represented District 8 at the South Carolina House of Representatives, 2007-2014
James Francis Byrnes (1879–1972), U.S. Representative and Senator, Associate Justice of the Supreme Court, Secretary of State, and Governor of South Carolina
Floride Calhoun (1792–1866), Second Lady of the United States; wife of John C. Calhoun
John C. Calhoun (1782–1850), U.S. Representative and Senator, Vice President, Secretary of State, and Secretary of War
Burnet Maybank (1899–1954), Charleston mayor 1931–1935; South Carolina governor 1939–1941; United States Senator from South Carolina[6]
Christopher Memminger (1803–1888), signer of the Confederate States Constitution; Confederate States Secretary of the Treasury 1861–1864
Thomas E. Miller, one of only five Black congressmen from the South in the Jim Crow era, son of Declaration of Independence signer Thomas Heyward Jr.
William Porcher Miles (1822–1899), lawyer; Mayor of Charleston 1855-1857; U.S. Representative from South Carolina; member of the Confederate Congress; designed the Confederate battle flag[7]
Charles Cotesworth Pinckney (1746–1825), American Revolutionary War leader; United States Ambassador to France; Federalist candidate for President
Joel Roberts Poinsett (1779–1851), botanist, politician, and diplomat; U.S. Representative; United States Ambassador to Mexico, Secretary of War; founded precursor to the Smithsonian Institution; namesake of the poinsettia
Alonzo J. Ransier, state senator and U.S. congressman; first African-American Lieutenant Governor of South Carolina
Edward Rutledge, signed the U.S. Declaration of Independence; Governor of South Carolina, 1798-1800
John Rutledge, President of South Carolina, 1776-1778; Commander and Chief of South Carolina forces during Revolutionary War; Governor of South Carolina, 1779-1782; second Chief Justice of the U.S. Supreme Court; signed the U.S. Constitution
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