Athletics
- George Arias – baseball player [1]
- Dave Baldwin – major league baseball player, writer, artist [2]
- Michael Bates – National Football League (NFL) player, sprinter, and 1992 Olympian [3]
- Stanley Berryhill – NFL player [4]
- Chad Beyer – cyclist [5]
- Craig Bjornson – baseball player and coach [6]
- Nat Borchers – soccer player [7]
- Alex Bowman – NASCAR driver [8]
- Henry Brauner – soccer player [9]
- Bryce Cotton – basketball player [10]
- Dominick Cruz – mixed martial artist [11]
- Lum Davenport – baseball player [12]
- Ike Davis – baseball player
- Chris Duncan – baseball player [13]
- Shelley Duncan – baseball player [14]
- Sean Elliott – basketball player [15]
- Cole Ford – football player [16]
- Jim Grabb – tennis player [17]
- J. J. Hardy – baseball player [18]
- Ron Hassey – baseball player [2]
- Gary Hayes – football player
- Alex Kellner – born in Tucson, baseball player [2]
- Walt Kellner – born in Tucson, baseball player [2]
- Mike Kellogg – football player
- Ian Kinsler – baseball player [19]
- Chris Knierim – pairs figure skater [20]
- Hank Leiber – baseball player [21]
- Eddie Leon – born in Tucson, baseball player [2]
- Lafayette Lever – basketball player [22]
- Caitlin Leverenz – Olympic swimmer, born in Tucson, attended Sahuaro High School [23]
- Pete McCaffrey – basketball player
- Roger McCluskey – National Sprint Car Hall of Fame racer [24]
- Alice Greenough Orr – rodeo star, originally from Montana [25]
- Tom Pagnozzi – baseball player
- Allen Pitts – Canadian Football League player
- Bijan Robinson – NFL running back for the Atlanta Falcons [26]
- Sam Sacksen – 2008 Beijing Olympic modern pentathlete [27]
- Anthony Shumaker – baseball player
- Tommy Silva – soccer player [28]
- Michael Smith – NFL running back [29]
- Brad Steinke – Emmy award-winning sportscaster [30]
- Kerri Strug – Olympic gold-medalist gymnast [31]
- Donny Toia – soccer player [32]
- Alex Verdugo – baseball player [33]
- Roman Bravo Young – freestyle and folkstyle wrestler, two-time NCAA champion for Penn State University [34]
- Win Young – Olympic medalist in diving [35]
