Marcus Raichle

Last updated

Marcus Raichle
Marcus Raichle 2014.jpg
Marcus Raichle in 2014
Born (1937-03-15) March 15, 1937 (age 82)
Known for default mode, functional neuroimaging
Awards Grawemeyer Award in Psychology (2001)
Kavli Prize in Neuroscience (2014)
Scientific career
Fields Neuroimaging
Institutions Washington University in St. Louis

Marcus E. Raichle (born March 15, 1937) is an American neurologist at the Washington University School of Medicine in Saint Louis, Missouri. He is a professor in the Department of Radiology with joint appointments in Neurology, Neurobiology and Biomedical Engineering. His research over the past 40 years has focused on the nature of functional brain imaging signals arising from PET and fMRI and the application of these techniques to the study of the human brain in health and disease. [1] He received the Kavli Prize in Neuroscience “for the discovery of specialized brain networks for memory and cognition", together with Brenda Milner and John O’Keefe in 2014.

Washington University School of Medicine Medical school in St. Louis, Missouri

Washington University School of Medicine (WUSM) is the medical school of Washington University in St. Louis in St. Louis, Missouri. Founded in 1891, the School of Medicine has 1,260 students, 604 of which are pursuing a medical degree with or without a combined Doctor of Philosophy or other advanced degree. It also offers doctorate degrees in biomedical research through the Division of Biology and Biological Sciences. The School has developed large physical therapy and occupational therapy programs, as well as the Program in Audiology and Communication Sciences which includes a Doctor of Audiology (Au.D.) degree and a Master of Science in Deaf Education (M.S.D.E.) degree. There are 1,772 faculty, 1,022 residents, and 765 fellows.

Neuroimaging set of techniques to measure and visualize aspects of the nervous system

Neuroimaging or brain imaging is the use of various techniques to either directly or indirectly image the structure, function, or pharmacology of the nervous system. It is a relatively new discipline within medicine, neuroscience, and psychology. Physicians who specialize in the performance and interpretation of neuroimaging in the clinical setting are neuroradiologists.

Brain organ that serves as the center of the nervous system in all vertebrate and most invertebrate animals

The brain is an organ that serves as the center of the nervous system in all vertebrate and most invertebrate animals. The brain is located in the head, usually close to the sensory organs for senses such as vision. The brain is the most complex organ in a vertebrate's body. In a human, the cerebral cortex contains approximately 14–16 billion neurons, and the estimated number of neurons in the cerebellum is 55–70 billion. Each neuron is connected by synapses to several thousand other neurons. These neurons communicate with one another by means of long protoplasmic fibers called axons, which carry trains of signal pulses called action potentials to distant parts of the brain or body targeting specific recipient cells.



Noteworthy accomplishments of Marcus Raichle include the discovery of the relative independence of blood flow and oxygen consumption during changes in brain activity which provided the physiological basis of fMRI; [2] the discovery of a default mode of brain function (i.e., organized intrinsic activity) and its signature system, [3] the brain’s default mode network; [4] and, the discovery that aerobic glycolysis contributes to brain function independent of oxidative phosphorylation. [5] [6]

Oxidative phosphorylation the phosphorylation of ADP to ATP that accompanies the oxidation of a metabolite through the operation of the respiratory chain. Oxidation of compounds establishes a proton gradient across the membrane, providing the energy for ATP synthesis.

Oxidative phosphorylation is the metabolic pathway in which cells use enzymes to oxidize nutrients, thereby releasing energy which is used to produce adenosine triphosphate (ATP). In most eukaryotes, this takes place inside mitochondria. Almost all aerobic organisms carry out oxidative phosphorylation. This pathway is probably so pervasive because it is a highly efficient way of releasing energy, compared to alternative fermentation processes such as anaerobic glycolysis.


National Academy of Sciences science branch of the United States National Academies

The National Academy of Sciences (NAS) is a United States nonprofit, non-governmental organization. NAS is part of the National Academies of Sciences, Engineering, and Medicine, along with the National Academy of Engineering (NAE) and the National Academy of Medicine (NAM).

American Academy of Arts and Sciences United States honorary society and center for independent policy research

The American Academy of Arts and Sciences is one of the oldest learned societies in the United States. Founded in 1780, the Academy is dedicated to honoring excellence and leadership, working across disciplines and divides, and advancing the common good.

American Association for the Advancement of Science international non-profit organization promoting science

The American Association for the Advancement of Science (AAAS) is an American international non-profit organization with the stated goals of promoting cooperation among scientists, defending scientific freedom, encouraging scientific responsibility, and supporting scientific education and science outreach for the betterment of all humanity. It is the world's largest general scientific society, with over 120,000 members, and is the publisher of the well-known scientific journal Science, which had a weekly circulation of 138,549 in 2008.


In 2001, he was a co-recipient of Grawemeyer Award in Psychology, with Michael Posner and Steven Petersen of the University of Louisville. [7] In 2010, he was awarded the Ariëns Kappers Medal from the Royal Netherlands Academy of Arts and Sciences. In 2014, he was a co-recipient of the Kavli Prize in Neuroscience, awarded by the Norwegian Academy of Science and Letters, with Brenda Milner of the Montreal Neurological Institute at McGill University and John O’Keefe of University College London. [8]

The Grawemeyer Awards are five awards given annually by the University of Louisville. The prizes are presented to individuals in the fields of education, ideas improving world order, music composition, religion, and psychology. The religion award is presented jointly by the University of Louisville and the Louisville Presbyterian Theological Seminary. Initially, the awards came with a bonus of US$150,000 each, making them among the most lucrative in their respective fields. This cash prize increased to $200,000 beginning in 2000. Beginning in 2011 the award amount dropped to $100,000 after the fund for the prize lost money due to a drop in the stock market.

University of Louisville Public university in Kentucky

The University of Louisville is a public university in Louisville, Kentucky, a member of the Kentucky state university system. When founded in 1798, it was the first city-owned public university in the United States and one of the first universities chartered west of the Allegheny Mountains. The university is mandated by the Kentucky General Assembly to be a "Preeminent Metropolitan Research University". The university enrolls students from 118 of 120 Kentucky counties, all 50 U.S. states, and 116 countries around the world.

Ariëns Kappers Medal

The Ariëns Kappers Medal is a scientific honor named after the Dutch neurologist Cornelius Ubbo Ariëns Kappers, the first director of the Netherlands Central Institute for Brain Research, now the Netherlands Institute for Neuroscience, from 1909-1946. The medal is awarded by the Royal Netherlands Academy of Arts and Sciences on recommendation of the Netherlands Institute for Neuroscience to people who have made an outstanding contribution to neuroscience.

Selected publications

Digital object identifier Character string used as a permanent identifier for a digital object, in a format controlled by the International DOI Foundation

In computing, a digital object identifier (DOI) is a persistent identifier or handle used to identify objects uniquely, standardized by the International Organization for Standardization (ISO). An implementation of the Handle System, DOIs are in wide use mainly to identify academic, professional, and government information, such as journal articles, research reports and data sets, and official publications though they also have been used to identify other types of information resources, such as commercial videos.

PubMed Central (PMC) is a free digital repository that archives publicly accessible full-text scholarly articles that have been published within the biomedical and life sciences journal literature. As one of the major research databases within the suite of resources that have been developed by the National Center for Biotechnology Information (NCBI), PubMed Central is much more than just a document repository. Submissions into PMC undergo an indexing and formatting procedure which results in enhanced metadata, medical ontology, and unique identifiers which all enrich the XML structured data for each article on deposit. Content within PMC can easily be interlinked to many other NCBI databases and accessed via Entrez search and retrieval systems, further enhancing the public's ability to freely discover, read and build upon this portfolio of biomedical knowledge.

Related Research Articles

Anterior cingulate cortex brain region

The anterior cingulate cortex (ACC) is the frontal part of the cingulate cortex that resembles a "collar" surrounding the frontal part of the corpus callosum. It consists of Brodmann areas 24, 32, and 33.

Brodmann area 9

Brodmann area 9, or BA9, is part of the frontal cortex in the brain of humans and other primates. It contributes to the dorsolateral and medial prefrontal cortex.

Posterior cingulate cortex

The posterior cingulate cortex (PCC) is the caudal part of the cingulate cortex, located posterior to the anterior cingulate cortex. This is the upper part of the "limbic lobe". The cingulate cortex is made up of an area around the midline of the brain. Surrounding areas include the retrosplenial cortex and the precuneus.

Intraparietal sulcus

The intraparietal sulcus (IPS) is located on the lateral surface of the parietal lobe, and consists of an oblique and a horizontal portion. The IPS contains a series of functionally distinct subregions that have been intensively investigated using both single cell neurophysiology in primates and human functional neuroimaging. Its principal functions are related to perceptual-motor coordination and visual attention, which allows for visually-guided pointing, grasping, and object manipulation that can produce a desired effect.

Michael I. Posner is an American psychologist, the editor of numerous cognitive and neuroscience compilations, and an eminent researcher in the field of attention. He is currently an emeritus professor of psychology at the University of Oregon, and an adjunct professor at the Weill Medical College in New York. A Review of General Psychology survey, published in 2002, ranked Posner as the 56th most cited psychologist of the 20th century.

Developmental cognitive neuroscience is an interdisciplinary scientific field devoted to understanding psychological processes and their neurological bases in the developing organism. It examines how the mind changes as children grow up, interrelations between that and how the brain is changing, and environmental and biological influences on the developing mind and brain.

The task-positive network (TPN) is a network of areas in the human brain that typically responds with activation increases to attention-demanding tasks in functional imaging studies. The task-positive network encompasses regions of the dorsal attention system, but in addition includes dorsolateral and ventrolateral prefrontal regions, the insular cortex, and the SMA/pre-SMA. Notably, the nodes of this network are also correlated during rest. The task-positive network is anti-correlated with the default mode network.Competing activation between the task-positive network and the default mode network at the time of memory encoding has been shown to result in poor long-term memory consolidation.

In neuroscience, a task-negative (TN) mode, also known as the default mode network, is inversely correlated to the task-positive mode. Its main function is to reorient attention towards salient stimuli. TN is considered to be involved mostly, if not entirely, in involuntary actions. The neural network is right hemisphere lateralized and includes the right temporal-parietal junction and the right ventral frontal cortex. This system shows activity increases upon detection of salient targets, especially when they appear in unexpected locations. Activity increases also are observed in the ventral system after abrupt changes in sensory stimuli, at the onset and offset of task blocks, and at the end of a completed trial.

Default mode network large scale brain network, active when one is not focused on the outside world and the brain is at wakeful rest (e.g. daydreaming), and also while thinking about others, thinking about oneself, remembering the past, and planning for the future

In neuroscience, the default mode network (DMN), also default network, or default state network, is a large scale brain network of interacting brain regions known to have activity highly correlated with each other and distinct from other networks in the brain.

Ann Graybiel American neuroscientist

Ann Martin Graybiel is an Institute Professor and a faculty member in the Department of Brain and Cognitive Sciences at the Massachusetts Institute of Technology. She is also an investigator at the McGovern Institute for Brain Research. She is an expert on the basal ganglia and the neurophysiology of habit formation, and her work is relevant to Parkinson's disease, Huntington's disease, obsessive–compulsive disorder, substance abuse and other disorders that affect the basal ganglia.

Resting state fMRI

Resting state fMRI is a method of functional magnetic resonance imaging (fMRI) that is used in brain mapping to evaluate regional interactions that occur in a resting or task-negative state, when an explicit task is not being performed. A number of resting-state conditions are identified in the brain, one of which is the default mode network. These resting brain state conditions are observed through changes in blood flow in the brain which creates what is referred to as a blood-oxygen-level dependent (BOLD) signal that can be measured using fMRI. Because brain activity is intrinsic, present even in the absence of an externally prompted task, any brain region will have spontaneous fluctuations in BOLD signal. The resting state approach is useful to explore the brain's functional organization and to examine if it is altered in neurological or mental disorders. Resting-state functional connectivity research has revealed a number of networks which are consistently found in healthy subjects, different stages of consciousness and across species, and represent specific patterns of synchronous activity.

Postmenopausal confusion is a symptom of menopause; women face problems with cognition during and after menopause due to hormonal imbalances.

John OKeefe (neuroscientist) American British neuroscientist, 2014 Nobel laureate in Physiology or Medicine

John O'Keefe, is an American-British neuroscientist and a professor at the Sainsbury Wellcome Centre for Neural Circuits and Behaviour and the Research Department of Cell and Developmental Biology at University College London. He discovered place cells in the hippocampus, and that they show a specific kind of temporal coding in the form of theta phase precession. In 2014 he received the Kavli Prize in Neuroscience "for the discovery of specialized brain networks for memory and cognition", together with Brenda Milner and Marcus Raichle. He shared the Nobel Prize in Physiology or Medicine also that year, together with May-Britt Moser and Edvard Moser.

CONN (functional connectivity toolbox)

CONN is a Matlab-based cross-platform imaging software for the computation, display, and analysis of functional connectivity in fMRI in the resting state and during task.

Randy L. Buckner is an American neuroscientist and psychologist whose research focuses on understanding how large-scale brain circuits support mental function and how dysfunction arises in illness.

Large scale brain networks are collections of widespread brain regions showing functional connectivity by statistical analysis of the fMRI BOLD signal or other signal fluctuations. An emerging paradigm in neuroscience is that cognitive tasks are performed not by individual brain regions working in isolation, but by networks consisting of several discrete brain regions that are said to be "functionally connected" due to tightly coupled activity. Functional connectivity may be measured as long-range synchronization of the EEG, MEG, or other dynamic brain signals. Synchronized brain regions may also be identified using spatial independent component analysis (ICA). The set of identified brain areas that are linked together in a large-scale network varies with cognitive function. When the cognitive state is not explicit, the large scale brain network is a resting state network (RSN). As a physical system with graph-like properties, a large scale brain network has both nodes and edges, and cannot be identified simply by the co-activation of brain areas. In recent decades, the analysis of brain networks was made feasible by advances in imaging techniques as well as new tools from graph theory and dynamical systems. Large scale brain networks are identified by their function, and provide a coherent framework for understanding cognition by offering a neural model of how different cognitive functions emerge when different sets of brain regions join together as self-organized coalitions. The identification of the coalitions will vary with different parameters used to run the ICA algorithm, which can results in a different number of networks. In one model, there is only the Default Mode Network and the task-positive network, but most current analyses show several networks, which are enumerated below. The property called functional network flexibility a brain region with strong functional connections within a brain network suddenly establish many connections to a different network.. The ICA algorithm Disruptions in activity in various networks have been implicated in neuropsychiatric disorders such as depression, Alzheimer's, autism spectrum disorder, schizophrenia and bipolar disorder..

Russell Poldrack American psychologist and neuroscientist

Russell "Russ" Alan Poldrack is an American psychologist and neuroscientist. He is a professor of Psychology at Stanford University, member of the Stanford Neuroscience Institute and director of the Stanford Center for Reproducible Neuroscience.

Salience network large scale brain network of the human brain, composed of the anterior insula and dorsal anterior cingulate cortex, which is involved in detecting and filtering salient stimuli, as well as in recruiting relevant functional networks

The salience network (SN) is a large scale brain network of the human brain that is primarily composed of the anterior insula (AI) and dorsal anterior cingulate cortex (dACC). It is involved in detecting and filtering salient stimuli, as well as in recruiting relevant functional networks. Together with its interconnected brain networks, the SN contributes to a variety of complex functions, including communication, social behavior, and self-awareness through the integration of sensory, emotional, and cognitive information.

Julie A. Fiez is a cognitive neuroscientist known for her research on the neural basis of speech, language, reading, working memory, and learning in healthy and patient populations. She is Professor of Psychology and Neuroscience at the Learning Research and Development Center and the Center for the Neural Basis of Cognition at the University of Pittsburgh. She is also Adjunct Faculty in the Department of Psychology at Carnegie Mellon University.

Social cognitive neuroscience is the scientific study of the biological processes underpinning social cognition. Specifically, it uses the tools of neuroscience to study "the mental mechanisms that create, frame, regulate, and respond to our experience of the social world". Social cognitive neuroscience uses the epistemological foundations of cognitive neuroscience, and is closely related to social neuroscience. Social cognitive neuroscience employs human neuroimaging, typically using functional magnetic resonance imaging (fMRI). Human brain stimulation techniques such as transcranial magnetic stimulation and transcranial direct-current stimulation are also used. In nonhuman animals, direct electrophysiological recordings and electrical stimulation of single cells and neuronal populations are utilized for investigating lower-level social cognitive processes.


  1. "Academy Members". Archived from the original on October 8, 2011.
  2. Petersen, SE; Fox PT; Posner MI; Mintun M; Raichle ME (1988). "Positron emission tomographic studies of the cortical anatomy of single-word processing". Nature. 331 (6157): 585–589. doi:10.1038/331585a0. PMID   3277066.
  3. Raichle, M. E.; MacLeod, A. M.; Snyder, A. Z.; Powers, W. J.; Gusnard, D. A.; Shulman, G. L. (January 16, 2001). "A default mode of brain function". Proceedings of the National Academy of Sciences of the United States of America. 98 (2): 676–682. doi:10.1073/pnas.98.2.676. ISSN   0027-8424. PMC   14647 . PMID   11209064.
  4. Fox, MD; Zhang D; Snyder DZ; Raichle ME (2009). "The global signal and observed anticorrelated resting state brain networks". J. Neurophysiol. 101 (6): 3270–3283. doi:10.1152/jn.90777.2008. PMC   2694109 . PMID   19339462.
  5. Vaishnavi, SN; Vlassenko AG; Rundle MM; Snyder AZ; Mintun MA; Raichle ME (2010). "Regional aerobic glycolysis in the human brain". PNAS. 107 (41): 17757–17762. doi:10.1073/pnas.1010459107. PMC   2955101 . PMID   20837536.
  6. Vlassenko AG, Vaishnavi SN, Couture L, Sacco D, Shannon BJ, Mac, RH, Morris JC, Raichle ME, Mintun MA (2010). "Spatial correlation between brain aerobic glycolysis and amyloid-β deposition". PNAS. 107 (41): 17763–17767. doi:10.1073/pnas.1010461107. PMC   2955133 . PMID   20837517.
  7. "2001– Michael Posner, Marcus Raichle and Steven Petersen". Archived from the original on May 21, 2014.
  8. Bhattacharjee, Yudhijit (May 29, 2014). "Nine Scientists Share Three Kavli Prizes".