Marcus Raichle | |
---|---|
Born | Hoquiam, Washington, US | March 15, 1937
Known for | default mode, functional neuroimaging |
Awards | Karl Spencer Lashley Award (1998) Grawemeyer Award in Psychology (2001) Kavli Prize in Neuroscience (2014) |
Scientific career | |
Fields | Neuroimaging |
Institutions | Washington University in St. Louis |
Marcus E. Raichle (born March 15, 1937) is an American neurologist at the Washington University School of Medicine in Saint Louis, Missouri. He is a professor in the Department of Radiology with joint appointments in Neurology, Neurobiology and Biomedical Engineering. His research over the past 40 years has focused on the nature of functional brain imaging signals arising from PET and fMRI and the application of these techniques to the study of the human brain in health and disease. [1] He received the Kavli Prize in Neuroscience “for the discovery of specialized brain networks for memory and cognition", together with Brenda Milner and John O’Keefe in 2014.
Noteworthy accomplishments of Marcus Raichle include the discovery of the relative independence of blood flow and oxygen consumption during changes in brain activity which provided the physiological basis of fMRI; [2] the discovery of a default mode of brain function (i.e., organized intrinsic activity) and its signature system, [3] the brain's default mode network; [4] and, the discovery that aerobic glycolysis contributes to brain function independent of oxidative phosphorylation. [5] [6]
In 2001, he was a co-recipient of Grawemeyer Award in Psychology, with Michael Posner and Steven Petersen of the University of Louisville. [8] In 2010, he was awarded the Metlife Foundation Award for Medical Research in Alzheimer's Disease along with Randy L. Buckner, [9] and the Ariëns Kappers Medal from the Royal Netherlands Academy of Arts and Sciences. In 2014, he was a co-recipient of the Kavli Prize in Neuroscience, awarded by the Norwegian Academy of Science and Letters, with Brenda Milner of the Montreal Neurological Institute at McGill University and John O’Keefe of University College London. [10]
In the human brain, the anterior cingulate cortex (ACC) is the frontal part of the cingulate cortex that resembles a "collar" surrounding the frontal part of the corpus callosum. It consists of Brodmann areas 24, 32, and 33.
Blood-oxygen-level-dependent imaging, or BOLD-contrast imaging, is a method used in functional magnetic resonance imaging (fMRI) to observe different areas of the brain or other organs, which are found to be active at any given time.
The intraparietal sulcus (IPS) is located on the lateral surface of the parietal lobe, and consists of an oblique and a horizontal portion. The IPS contains a series of functionally distinct subregions that have been intensively investigated using both single cell neurophysiology in primates and human functional neuroimaging. Its principal functions are related to perceptual-motor coordination and visual attention, which allows for visually-guided pointing, grasping, and object manipulation that can produce a desired effect.
Michael I. Posner is an American psychologist who is a researcher in the field of attention, and the editor of numerous cognitive and neuroscience compilations. He is emeritus professor of psychology at the University of Oregon, and an adjunct professor at the Weill Medical College in New York. A Review of General Psychology survey, published in 2002, ranked Posner as the 56th most cited psychologist of the 20th century.
The dorsal attention network (DAN), also known anatomically as the dorsal frontoparietal network (D-FPN), is a large-scale brain network of the human brain that is primarily composed of the intraparietal sulcus (IPS) and frontal eye fields (FEF). It is named and most known for its role in voluntary orienting of visuospatial attention.
In neuroscience, the default mode network (DMN), also known as the default network, default state network, or anatomically the medial frontoparietal network (M-FPN), is a large-scale brain network primarily composed of the dorsal medial prefrontal cortex, posterior cingulate cortex, precuneus and angular gyrus. It is best known for being active when a person is not focused on the outside world and the brain is at wakeful rest, such as during daydreaming and mind-wandering. It can also be active during detailed thoughts related to external task performance. Other times that the DMN is active include when the individual is thinking about others, thinking about themselves, remembering the past, and planning for the future.
Resting state fMRI is a method of functional magnetic resonance imaging (fMRI) that is used in brain mapping to evaluate regional interactions that occur in a resting or task-negative state, when an explicit task is not being performed. A number of resting-state brain networks have been identified, one of which is the default mode network. These brain networks are observed through changes in blood flow in the brain which creates what is referred to as a blood-oxygen-level dependent (BOLD) signal that can be measured using fMRI.
The biological basis of personality is a collection of brain systems and mechanisms that underlie human personality. Human neurobiology, especially as it relates to complex traits and behaviors, is not well understood, but research into the neuroanatomical and functional underpinnings of personality are an active field of research. Animal models of behavior, molecular biology, and brain imaging techniques have provided some insight into human personality, especially trait theories.
Peter T. Fox is a neuroimaging researcher and neurologist at the University of Texas Health Science Center at San Antonio. He is a professor in the Department of Radiology with joint appointments in Radiology, Medicine, and Psychiatry. He is the founding director of the Research Imaging Institute.
John O'Keefe, is an American-British neuroscientist, psychologist and a professor at the Sainsbury Wellcome Centre for Neural Circuits and Behaviour and the Research Department of Cell and Developmental Biology at University College London. He discovered place cells in the hippocampus, and that they show a specific kind of temporal coding in the form of theta phase precession. He shared the Nobel Prize in Physiology or Medicine in 2014, together with May-Britt Moser and Edvard Moser; he has received several other awards. He has worked at University College London for his entire career, but also held a part-time chair at the Norwegian University of Science and Technology at the behest of his Norwegian collaborators, the Mosers.
Randy L. Buckner is an American neuroscientist and psychologist whose research focuses on understanding how large-scale brain circuits support mental function and how dysfunction arises in illness.
Large-scale brain networks are collections of widespread brain regions showing functional connectivity by statistical analysis of the fMRI BOLD signal or other recording methods such as EEG, PET and MEG. An emerging paradigm in neuroscience is that cognitive tasks are performed not by individual brain regions working in isolation but by networks consisting of several discrete brain regions that are said to be "functionally connected". Functional connectivity networks may be found using algorithms such as cluster analysis, spatial independent component analysis (ICA), seed based, and others. Synchronized brain regions may also be identified using long-range synchronization of the EEG, MEG, or other dynamic brain signals.
Russell "Russ" Alan Poldrack is an American psychologist and neuroscientist. He is a professor of psychology at Stanford University, associate director of Stanford Data Science, member of the Stanford Neuroscience Institute and director of the Stanford Center for Reproducible Neuroscience and the SDS Center for Open and Reproducible Science.
The salience network (SN), also known anatomically as the midcingulo-insular network (M-CIN) or ventral attention network, is a large scale network of the human brain that is primarily composed of the anterior insula (AI) and dorsal anterior cingulate cortex (dACC). It is involved in detecting and filtering salient stimuli, as well as in recruiting relevant functional networks. Together with its interconnected brain networks, the SN contributes to a variety of complex functions, including communication, social behavior, and self-awareness through the integration of sensory, emotional, and cognitive information.
Julie A. Fiez is a cognitive neuroscientist known for her research on the neural basis of speech, language, reading, working memory, and learning in healthy and patient populations. She is Professor of Psychology and Neuroscience at the Learning Research and Development Center and the Center for the Neural Basis of Cognition at the University of Pittsburgh. She is also Adjunct Faculty in the Department of Psychology at Carnegie Mellon University.
Network neuroscience is an approach to understanding the structure and function of the human brain through an approach of network science, through the paradigm of graph theory. A network is a connection of many brain regions that interact with each other to give rise to a particular function. Network Neuroscience is a broad field that studies the brain in an integrative way by recording, analyzing, and mapping the brain in various ways. The field studies the brain at multiple scales of analysis to ultimately explain brain systems, behavior, and dysfunction of behavior in psychiatric and neurological diseases. Network neuroscience provides an important theoretical base for understanding neurobiological systems at multiple scales of analysis.
The frontoparietal network (FPN), generally also known as the central executive network (CEN) or, more specifically, the lateral frontoparietal network (L-FPN), is a large-scale brain network primarily composed of the dorsolateral prefrontal cortex and posterior parietal cortex, around the intraparietal sulcus. It is involved in sustained attention, complex problem-solving and working memory.
Betty Jo "BJ" Casey is an American cognitive neuroscientist and expert on adolescent brain development and self control. She is the Christina L. Williams Professor of Neuroscience at Barnard College of Columbia University where she directs the Fundamentals of the Adolescent Brain (FAB) Lab and is an Affiliated Professor of the Justice Collaboratory at Yale Law School, Yale University.
Michael D. Fox is an American neurologist and Professor of Neurology at Harvard Medical School in Boston, Massachusetts where he holds the Raymond D. Adams Distinguished Chair in Neurology and directs the Center for Brain Circuit Therapeutics at Brigham and Women's Hospital. His research has focused on resting state brain fMRI which uses spontaneous fluctuations in blood oxygenation to map brain networks including the default mode network. He developed the technique lesion network mapping to study the connectivity patterns of brain lesions to help understand the neuroanatomy of a diverse range of processes including addiction, criminality, blindsight, free will and religiosity. Michael D. Fox has been considered among the "World's Most Influential Scientific Minds" by Thomson Reuters since 2014.
Alan Anticevic is a Croatian neuroscientist known for his contributions to the fields of cognitive neuroscience, computational psychiatry, and neuroimaging studies of severe psychiatric illnesses.