Matthew Hurles

Last updated

Matt Hurles
FRS FMedSci
Born
Matthew Edward Hurles

(1974-05-08) 8 May 1974 (age 50) [1] [2]
Hammersmith, London, England [1]
Education Hampton School
Alma mater University of Oxford (BA) [3]
University of Leicester (PhD)
Awards Crick Lecture (2013) [4]
Scientific career
Fields Genetics [5]
Institutions Wellcome Sanger Institute
University of Cambridge
Congenica Ltd [2]
Thesis Mutation and variability of the human Y chromosome  (1999)
Doctoral advisor Mark Jobling [3]
Website www.sanger.ac.uk/people/directory/hurles-matthew

Matthew Edward Hurles (born 1974) [1] is a British scientist who is director of the Wellcome Sanger Institute [6] [5] and an honorary professor of Human Genetics and Genomics at the University of Cambridge. [7]

Contents

Education

Hurles was privately educated at Hampton School [1] and the University of Oxford where he was awarded a Bachelor of Arts degree in Biochemistry. He completed his PhD in 1999 on the genetics of the Y chromosome at the University of Leicester supervised by Mark Jobling [3] [8] [9]

Research and career

Hurles research investigates the causes and consequences of new mutations as DNA is passed from one generation to the next. [4] He is best known for his work on characterizing the extent and impact of structural variation in the human genome and on deciphering the genetic architecture of severe neurodevelopmental disorders. [4]

Hurles group has used large-scale genomic studies to highlight the predominant role that new mutations of many different types play in causing diverse developmental disorders and has led to the discovery of tens of previously unrecognised genetic diseases. [4] [10] [11] [12]

Awards and honours

Hurles was elected a Fellow of the Royal Society (FRS) in 2019. [1] [4] He is also a Fellow of the Academy of Medical Sciences (FMedSci) and was awarded the Crick Medal and Lecture in 2013. [4]

References

  1. 1 2 3 4 5 Anon (2023). "HURLES, Dr. Matthew" . Who's Who (online Oxford University Press  ed.). Oxford: A & C Black. doi:10.1093/ww/9780199540884.013.U290131.(Subscription or UK public library membership required.)
  2. 1 2 Anon (2018). "Matthew Hurles: Congenica Ltd". companieshouse.gov.uk. London: Companies House. Archived from the original on 25 October 2019.
  3. 1 2 3 Hurles, Matthew (1999). Mutation and variability of the human Y chromosome. le.ac.uk (PhD thesis). University of Leicester. hdl:2381/30320. OCLC   505103676. EThOS   uk.bl.ethos.696631. Open Access logo PLoS transparent.svg
  4. 1 2 3 4 5 6 Anon (2019). "Professor Matthew Hurles FMedSci FRS". royalsociety.org. London: Royal Society. Archived from the original on 24 April 2019. One or more of the preceding sentences incorporates text from the royalsociety.org website where:
    “All text published under the heading 'Biography' on Fellow profile pages is available under Creative Commons Attribution 4.0 International License.” --Royal Society Terms, conditions and policies at the Wayback Machine (archived 2016-11-11)
  5. 1 2 Matthew Hurles publications indexed by Google Scholar OOjs UI icon edit-ltr-progressive.svg
  6. ↑ Matthew Hurles publications indexed by the Scopus bibliographic database. (subscription required)
  7. ↑ Matthew Hurles publications from Europe PubMed Central
  8. ↑ Hurles, Matthew E.; Veitia, Reiner; Arroyo, Eduardo; Armenteros, Manuel; Bertranpetit, Jaume; Pérez-Lezaun, Anna; Bosch, Elena; Shlumukova, Maria; Cambon-Thomsen, Anne; McElreavey, Ken; López de Munain, Adolfo; Röhl, Arne; Wilson, Ian J.; Singh, Lalji; Pandya, Arpita; Santos, Fabrício R.; Tyler-Smith, Chris; Jobling, Mark A. (1999). "Recent Male-Mediated Gene Flow over a Linguistic Barrier in Iberia, Suggested by Analysis of a Y-Chromosomal DNA Polymorphism". The American Journal of Human Genetics. 65 (5): 1437–1448. doi:10.1086/302617. ISSN   0002-9297. PMC   1288297 . PMID   10521311.
  9. ↑ Hurles, Matthew E.; Irven, Catherine; Nicholson, Jayne; Taylor, Paul G.; Santos, Fabricio R.; Loughlin, John; Jobling, Mark A.; Sykes, Bryan C. (1998). "European Y-Chromosomal Lineages in Polynesians: A Contrast to the Population Structure Revealed by mtDNA". The American Journal of Human Genetics. 63 (6): 1793–1806. doi:10.1086/302147. ISSN   0002-9297. PMC   1377652 . PMID   9837833.
  10. ↑ The 1000 Genomes Project Consortium (2010). "A map of human genome variation from population-scale sequencing". Nature. 467 (7319): 1061–1073. Bibcode:2010Natur.467.1061T. doi:10.1038/nature09534. ISSN   0028-0836. PMC   3042601 . PMID   20981092.{{cite journal}}: CS1 maint: numeric names: authors list (link)
  11. ↑ The 1000 Genomes Project Consortium (2012). "An integrated map of genetic variation from 1,092 human genomes". Nature. 491 (7422): 56–65. Bibcode:2012Natur.491...56T. doi:10.1038/nature11632. ISSN   0028-0836. PMC   3498066 . PMID   23128226.{{cite journal}}: CS1 maint: numeric names: authors list (link)
  12. ↑ Redon, Richard; Ishikawa, Shumpei; Fitch, Karen R.; Feuk, Lars; Perry, George H.; Andrews, T. Daniel; Fiegler, Heike; Shapero, Michael H.; Carson, Andrew R.; Chen, Wenwei; Cho, Eun Kyung; Dallaire, Stephanie; Freeman, Jennifer L.; González, Juan R.; Gratacòs, Mònica; Huang, Jing; Kalaitzopoulos, Dimitrios; Komura, Daisuke; MacDonald, Jeffrey R.; Marshall, Christian R.; Mei, Rui; Montgomery, Lyndal; Nishimura, Kunihiro; Okamura, Kohji; Shen, Fan; Somerville, Martin J.; Tchinda, Joelle; Valsesia, Armand; Woodwark, Cara; Yang, Fengtang; Zhang, Junjun; Zerjal, Tatiana; Zhang, Jane; Armengol, Lluis; Conrad, Donald F.; Estivill, Xavier; Tyler-Smith, Chris; Carter, Nigel P.; Aburatani, Hiroyuki; Lee, Charles; Jones, Keith W.; Scherer, Stephen W.; Hurles, Matthew E. (2006). "Global variation in copy number in the human genome". Nature. 444 (7118): 444–454. Bibcode:2006Natur.444..444R. doi:10.1038/nature05329. ISSN   0028-0836. PMC   2669898 . PMID   17122850.
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