Caetano Reis e Sousa

Last updated

Caetano Reis e Sousa

Born
Caetano Maria Pacheco Pais dos Reis e Sousa

1968 (age 5455) [1]
Education Atlantic College
Alma mater Imperial College London (BSc)
University of Oxford (DPhil)
Awards EMBO Member (2006) [2]
Louis-Jeantet Prize for Medicine (2017)
Scientific career
Fields Immunology [3]
Institutions Francis Crick Institute
Imperial College London
Imperial Cancer Research Fund
National Institute of Allergy and Infectious Diseases
Thesis Phagocytosis of antigens by Langerhans cells
Doctoral advisor Jonathan Austyn
Website www.crick.ac.uk/research/labs/caetano-reis-e-sousa

Caetano Maria Pacheco Pais dos Reis e Sousa (born 1968) [1] FRS FMedSci is a senior group leader at the Francis Crick Institute [3] [4] [5] [6] and a professor of Immunology at Imperial College London. [7]

Contents

Education

Reis e Sousa was educated at Atlantic College in Wales, [6] Imperial College London (BSc) and the University of Oxford where he was awarded a Doctor of Philosophy degree in 1992 for research on dendritic cells, and the phagocytosis of antigens by Langerhans cells supervised by Jonathan Austyn. [8]

Career and research

After working as a postdoctoral researcher at the National Institute of Allergy and Infectious Diseases (NIAID) in the United States, with Ronald Germain, he joined the Imperial Cancer Research Fund (ICRF) in 1998. [9] He headed the Immunobiology Laboratory which became part of the Francis Crick Institute in 2015. [9] He is also a professor of Immunology at Imperial College London [10] [7] and honorary professor at University College London (UCL) and King's College London. [9]

Caetano's research centres on the mechanisms involved in sensing infection, cancer and tissue injury. [9] He has helped to define the cells and pathways involved in innate immune detection of RNA viruses, fungi and dead cells. [9] [11] [12] [13]

Awards and honours

Reis e Sousa was elected a Fellow of the Royal Society (FRS) in 2019, and is also a Fellow of the Academy of Medical Sciences (FMedSci), a member of the European Molecular Biology Organization (EMBO) [2] and was made an Officer of the Order of Sant'Iago da Espada by the Government of Portugal in 2009. [9] He was awarded the Louis-Jeantet Prize for Medicine in 2017. [1]

Related Research Articles

<span class="mw-page-title-main">David Baulcombe</span> British plant scientist and geneticist

Sir David Charles Baulcombe is a British plant scientist and geneticist. As of 2017 he is a Royal Society Research Professor. From 2007 to 2020 he was Regius Professor of Botany in the Department of Plant Sciences at the University of Cambridge.

Sir John Stewart Savill, FRS, FMedSci is the Chief Executive of the Medical Research Council (MRC) in the UK and the Head of the College of Medicine and Veterinary Medicine and a Vice Principal of the University of Edinburgh.

<span class="mw-page-title-main">Tomas Lindahl</span> Swedish-British scientist

Tomas Robert Lindahl FRS FMedSci is a Swedish-British scientist specialising in cancer research. In 2015, he was awarded the Nobel Prize in Chemistry jointly with American chemist Paul L. Modrich and Turkish chemist Aziz Sancar for mechanistic studies of DNA repair.

Sir John James Skehel, is a British virologist and Emeritus scientist at the Francis Crick Institute in London. From 1987 to 2006 he was director of the National Institute of Medical Research (NIMR) at Mill Hill which was incorporated into the Crick Institute in 2016.

Christopher John Marshall FRS FMedSci was a British scientist who worked as director of the Division for Cancer Biology at the Institute of Cancer Research. Marshall was distinguished for research in the field of tumour cell signalling. His track record includes the discovery of the N-Ras oncogene , the identification of farnesylation of Ras proteins, and the discovery that Ras signals through the MAPK/ERK pathway. These findings have led to therapeutic development of inhibitors of Ras farnesylation, MEK and B-Raf.

<span class="mw-page-title-main">Jim Cuthbert Smith</span>

Sir James Cuthbert Smith is Director of Science at the Wellcome Trust, Senior Group Leader at the Francis Crick Institute and President of the Council at Zoological Society of London.

<span class="mw-page-title-main">Robin Lovell-Badge</span> British biologist

Robin Howard Lovell-Badge, CBE, FRS FMedSci is a British scientist most famous for his discovery, along with Peter Goodfellow, of the SRY gene on the Y-chromosome that is the determinant of sex in mammals. They shared the 1995 Louis-Jeantet Prize for Medicine for their discovery. He was awarded the 2022 Genetics Society Medal. He is currently a Senior Group Leader and Head of the Laboratory of Stem Cell Biology and Developmental Genetics at the Francis Crick Institute in Central London.

<span class="mw-page-title-main">Iain Mattaj</span> British scientist

Iain William Mattaj FRS FRSE is a British scientist and Honorary Professor at Heidelberg University in Germany. From 2005 to 2018 he was Director General of the European Molecular Biology Laboratory (EMBL). He stepped down from the position at the end of 2018 following his appointment to Human Technopole. In January 2019 he took office as the first Director of Human Technopole, the new Italian institute for life sciences in Milan, Italy.

Sir Hugh Reginald Brentnall Pelham, is a cell biologist who has contributed to our understanding of the body's response to rises in temperature through the synthesis of heat shock proteins. He served as director of the Medical Research Council (MRC) Laboratory of Molecular Biology (LMB) between 2006 and 2018.

<span class="mw-page-title-main">Adrian Hayday</span> British immunologist (born 1956)

Adrian Clive Hayday is the Kay Glendinning professor and chair in the Department of Immunobiology at King's College London and group leader at the Francis Crick Institute in the UK.

<span class="mw-page-title-main">E. Yvonne Jones</span> Director of the Cancer Research UK Receptor Structure Research Group

(Edith) Yvonne JonesFLSW is director of the Cancer Research UK Receptor Structure Research Group at the University of Oxford and a Fellow of Jesus College, Oxford. She is widely known for her research on the molecular biology of cell surface receptors and signalling complexes.

<span class="mw-page-title-main">Anne Ridley</span> Professor of Cell Biology

Anne Jacqueline Ridley is professor of Cell Biology and Head of School for Cellular and Molecular Medicine at the University of Bristol. She was previously a professor at King's College London.

James Briscoe is a senior group leader at the Francis Crick Institute in London and editor-in-chief of the journal Development.

<span class="mw-page-title-main">Richard Treisman</span> British scientist

Sir Richard Henry Treisman is a British scientist specialising in the molecular biology of cancer. Treisman is a director of research at the Francis Crick Institute in London.

<span class="mw-page-title-main">Neil Brockdorff</span> British biochemist (born 1958)

Neil Alexander Steven Brockdorff is a Wellcome Trust Principal Research Fellow and professor in the department of biochemistry at the University of Oxford. Brockdorff's research investigates gene and genome regulation in mammalian development. His interests are in the molecular basis of X-inactivation, the process that evolved in mammals to equalise X chromosome gene expression levels in XX females relative to XY males.

<span class="mw-page-title-main">Charles Swanton</span>

(Robert) Charles Swanton is British physician scientist specialising in oncology and cancer research. Swanton is a senior group leader at London's Francis Crick Institute, Royal Society Napier Professor in Cancer and thoracic medical oncologist at University College London and University College London Hospitals, co-director of the Cancer Research UK (CRUK) Lung Cancer Centre of Excellence, and Chief Clinician of Cancer Research UK.

John Francis Xavier Diffley is an American biochemist and Associate Research Director at the Francis Crick Institute. He is known for his contributions to the understanding of how DNA replication is initiated, and how it is subsequently regulated throughout the cell cycle and in response to DNA damage.

Charles Bangham holds the Chair in Immunology at Imperial College London.

Jonathan M. Austyn is Professor of Immunobiology at the University of Oxford and a Fellow of Wolfson College, Oxford. He has taught immunology over many years, and designed the Master of Science course in Integrated Immunology at the University of Oxford, which he co-directs.

Judith Elizabeth Allen is a British scientist who is Professor of Immunobiology at the University of Manchester. She is an expert on macrophages activated during helminthiasis and was elected Fellow of the Royal Society (FRS) in 2023.

References

  1. 1 2 3 4 "Caetano REIS E SOUSA". jeantet.ch. 4 October 2017.
  2. 1 2 Anon (2006). "Caetano Reis e Sousa". people.embo.org. European Molecular Biology Organization.
  3. 1 2 Caetano Reis e Sousa publications indexed by Google Scholar OOjs UI icon edit-ltr-progressive.svg
  4. "Caetano Reis e Sousa: Immunobiology Laboratory". crick.ac.uk.
  5. "Researchers: Caetano Reis e Sousa". crick.ac.uk.
  6. 1 2 Bashyam, Hema (2008). "Caetano Reis e Sousa: harnessing DC power". The Journal of Experimental Medicine. 205 (9): 1946–1947. doi:10.1084/jem.2059pi. ISSN   0022-1007. PMC   2526189 . PMID   18762569.
  7. 1 2 "Professor Caetano Reis e Sousa". Imperial College London.
  8. Reis e Sousa, Caetano Maria Pacheco Pais dos (1992). Phagocytosis of antigens by Langerhans cells (DPhil thesis). University of Oxford. OCLC   863542179. EThOS   uk.bl.ethos.314901. Lock-green.svg
  9. 1 2 3 4 5 6 Anon (2019). "Professor Caetano Reis e Sousa FMedSci FRS". royalsociety.org. London: Royal Society. Archived from the original on 24 April 2019. One or more of the preceding sentences incorporates text from the royalsociety.org website where:
    "All text published under the heading 'Biography' on Fellow profile pages is available under Creative Commons Attribution 4.0 International License." --Royal Society Terms, conditions and policies at the Wayback Machine (archived 2016-11-11)
  10. Caetano Reis e Sousa publications from Europe PubMed Central
  11. Diebold, S. S. (2004). "Innate Antiviral Responses by Means of TLR7-Mediated Recognition of Single-Stranded RNA". Science. 303 (5663): 1529–1531. Bibcode:2004Sci...303.1529D. doi: 10.1126/science.1093616 . ISSN   0036-8075. PMID   14976261. S2CID   33144196. Closed Access logo transparent.svg
  12. Kato, Hiroki; Takeuchi, Osamu; Sato, Shintaro; Yoneyama, Mitsutoshi; Yamamoto, Masahiro; Matsui, Kosuke; Uematsu, Satoshi; Jung, Andreas; Kawai, Taro; Ishii, Ken J.; Yamaguchi, Osamu; Otsu, Kinya; Tsujimura, Tohru; Koh, Chang-Sung; Reis e Sousa, Caetano; Matsuura, Yoshiharu; Fujita, Takashi; Akira, Shizuo (2006). "Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses". Nature. 441 (7089): 101–105. Bibcode:2006Natur.441..101K. doi:10.1038/nature04734. ISSN   0028-0836. PMID   16625202. S2CID   2270879. Closed Access logo transparent.svg
  13. Pichlmair, A.; Schulz, O.; Tan, C. P.; Naslund, T. I.; Liljestrom, P.; Weber, F.; Reis e Sousa, C. (2006). "RIG-I-Mediated Antiviral Responses to Single-Stranded RNA Bearing 5'-Phosphates". Science. 314 (5801): 997–1001. Bibcode:2006Sci...314..997P. doi:10.1126/science.1132998. ISSN   0036-8075. PMID   17038589. S2CID   44366096. Closed Access logo transparent.svg