Sarah Darby | |
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Born | Sarah C. Darby |
Education | Imperial College London (BSc) University of Birmingham (MSc) London School of Hygiene and Tropical Medicine (PhD) |
Scientific career | |
Fields | Epidemiology Statistics Cancer |
Institutions | University of Oxford Radcliffe Infirmary St Thomas's Hospital Medical School National Radiological Protection Board Radiation Effects Research Foundation |
Thesis | A Bayesian Approach to Parallel Line Bioassay (1977) |
Doctoral students | Helen Weiss |
Website | www |
Sarah C. Darby FRS is Professor of Medical Statistics at the University of Oxford. [1] Her research has focused the beneficial effects of smoking cessation, the risk of lung cancer from residential radon, [2] and treatments for early breast cancer. [3] She is also a Principal Scientist with the Cancer Research UK in the Clinical Trial Service Unit (CTSU) and Epidemiological Studies Unit at the Nuffield Department of Clinical Medicine, at the Radcliffe Infirmary, Oxford. [4] [5]
Darby studied Mathematics at Imperial College London (BSc) and Mathematical Statistics at the University of Birmingham (MSc). [6] She completed her PhD at the London School of Hygiene and Tropical Medicine in 1977 where her research investigated Bayesian approaches to analysing bioassays. [7]
After her PhD, she worked at St Thomas's Hospital Medical School, the National Radiological Protection Board, and the Radiation Effects Research Foundation in Hiroshima, before moving to the University of Oxford in 1984. Her major funder since then has been Cancer Research UK. [6]
Darby and her team have demonstrated that there is a linear relationship between the dose of radiation delivered incidentally to the heart during breast cancer radiotherapy and the subsequent risk of ischaemic heart disease, and that the absolute size of the radiation-related risk is bigger for women already at increased risk of heart disease. [6] [8]
She and her team have also estimated the absolute size of the benefit of radiotherapy to breast cancer patients and their work is enabling comparison of the likely absolute benefit of radiotherapy with its likely absolute risk for individual patients. [6] Therefore, it is now becoming possible to assess which patients can receive standard radiotherapy, which should be considered for advanced techniques, and which should avoid radiotherapy altogether. [6] [9]
Other topics that Darby has worked on include estimating the risk of lung cancer from residential radon, the risk of invasive breast cancer after a diagnosis of ductal carcinoma in situ , and the risk of cancer after computerised tomography (CT) scans in young people. [6] [10]
Darby was awarded the Guy Medal in Bronze in 1988 by the Royal Statistical Society. [11] She was elected a Fellow of the Royal Society (FRS) in 2019. [6]
Lung cancer, also known as lung carcinoma, is a malignant tumor that begins in the lung. Lung cancer is caused by genetic damage to the DNA of cells in the airways, often caused by cigarette smoking or inhaling damaging chemicals. Damaged airway cells gain the ability to multiply unchecked, causing the growth of a tumor. Without treatment, tumors spread throughout the lung, damaging lung function. Eventually lung tumors metastasize, spreading to other parts of the body.
Radon is a chemical element; it has symbol Rn and atomic number 86. It is a radioactive noble gas and is colorless and odorless. Of the three naturally occurring radon isotopes, only radon-222 has a sufficiently long half-life for it to be released from the soil and rock where it is generated. Radon isotopes are the immediate decay products of radium isotopes. The instability of radon-222, its most stable isotope, makes radon one of the rarest elements. Radon will be present on Earth for several billion more years, despite its short half-life, because it is constantly being produced as a step in the decay chain of uranium-238, and that of thorium-232, each of which is an extremely abundant radioactive nuclide with a half-life of several billion years. The decay of radon produces many other short-lived nuclides, known as "radon daughters", ending at stable isotopes of lead. Radon-222 occurs in significant quantities as a step in the normal radioactive decay chain of uranium-238, also known as the uranium series, which slowly decays into a variety of radioactive nuclides and eventually decays into lead-206, which is stable. Radon-220 occurs in minute quantities as an intermediate step in the decay chain of thorium-232, also known as the thorium series, which eventually decays into lead-208, which is stable.
Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body. These contrast with benign tumors, which do not spread. Possible signs and symptoms include a lump, abnormal bleeding, prolonged cough, unexplained weight loss, and a change in bowel movements. While these symptoms may indicate cancer, they can also have other causes. Over 100 types of cancers affect humans.
Brachytherapy is a form of radiation therapy where a sealed radiation source is placed inside or next to the area requiring treatment. Brachy is Greek for short. Brachytherapy is commonly used as an effective treatment for cervical, prostate, breast, esophageal and skin cancer and can also be used to treat tumours in many other body sites. Treatment results have demonstrated that the cancer-cure rates of brachytherapy are either comparable to surgery and external beam radiotherapy (EBRT) or are improved when used in combination with these techniques. Brachytherapy can be used alone or in combination with other therapies such as surgery, EBRT and chemotherapy.
Passive smoking is the inhalation of tobacco smoke, called passive smoke, secondhand smoke (SHS) or environmental tobacco smoke (ETS), by individuals other than the active smoker. It occurs when tobacco smoke diffuses into the surrounding atmosphere as an aerosol pollutant, which leads to its inhalation by nearby bystanders within the same environment. Exposure to secondhand tobacco smoke causes many of the same diseases caused by active smoking, although to a lower prevalence due to the reduced concentration of smoke that enters the airway.
In epidemiology, a risk factor or determinant is a variable associated with an increased risk of disease or infection.
The Women's Health Initiative (WHI) was a series of clinical studies initiated by the U.S. National Institutes of Health (NIH) in 1991, to address major health issues causing morbidity and mortality in postmenopausal women. It consisted of three clinical trials (CT) and an observational study (OS). In particular, randomized controlled trials were designed and funded that addressed cardiovascular disease, cancer, and osteoporosis.
Sir Richard Peto is an English statistician and epidemiologist who is Professor of Medical Statistics and Epidemiology at the University of Oxford, England.
Adjuvant therapy, also known as adjunct therapy, adjuvant care, or augmentation therapy, is a therapy that is given in addition to the primary or initial therapy to maximize its effectiveness. The surgeries and complex treatment regimens used in cancer therapy have led the term to be used mainly to describe adjuvant cancer treatments. An example of such adjuvant therapy is the additional treatment usually given after surgery where all detectable disease has been removed, but where there remains a statistical risk of relapse due to the presence of undetected disease. If known disease is left behind following surgery, then further treatment is not technically adjuvant.
Overdiagnosis is the diagnosis of disease that will never cause symptoms or death during a patient's ordinarily expected lifetime and thus presents no practical threat regardless of being pathologic. Overdiagnosis is a side effect of screening for early forms of disease. Although screening saves lives in some cases, in others it may turn people into patients unnecessarily and may lead to treatments that do no good and perhaps do harm. Given the tremendous variability that is normal in biology, it is inherent that the more one screens, the more incidental findings will generally be found. For a large percentage of them, the most appropriate medical response is to recognize them as something that does not require intervention; but determining which action a particular finding warrants can be very difficult, whether because the differential diagnosis is uncertain or because the risk ratio is uncertain.
Tobacco products, especially when smoked or used orally, have negative effects on human health. Researchers have addressed concerns about these effects for a long time. They have focused primarily on cigarette smoking.
The European Prospective Investigation into Cancer and Nutrition (EPIC) study is a Europe-wide prospective cohort study of the relationships between diet and cancer, as well as other chronic diseases, such as cardiovascular disease. With over half a million participants, it is the largest study of diet and disease to be undertaken.
Ductal carcinoma in situ (DCIS), also known as intraductal carcinoma, is a pre-cancerous or non-invasive cancerous lesion of the breast. DCIS is classified as Stage 0. It rarely produces symptoms or a breast lump that can be felt, typically being detected through screening mammography. It has been diagnosed in a significant percentage of men.
Hormone replacement therapy (HRT), also known as menopausal hormone therapy or postmenopausal hormone therapy, is a form of hormone therapy used to treat symptoms associated with female menopause. Effects of menopause can include symptoms such as hot flashes, accelerated skin aging, vaginal dryness, decreased muscle mass, and complications such as osteoporosis, sexual dysfunction, and vaginal atrophy. They are mostly caused by low levels of female sex hormones that occur during menopause.
The health effects of radon are harmful, and include an increased chance of lung cancer. Radon is a radioactive, colorless, odorless, tasteless noble gas, which has been studied by a number of scientific and medical bodies for its effects on health. A naturally-occurring gas formed as a decay product of radium, radon is one of the densest substances that remains a gas under normal conditions, and is considered to be a health hazard due to its radioactivity. Its most stable isotope, radon-222, has a half-life of 3.8 days. Due to its high radioactivity, it has been less well studied by chemists, but a few compounds are known.
Targeted intra-operative radiotherapy, also known as targeted IORT, is a technique of giving radiotherapy to the tissues surrounding a cancer after its surgical removal, a form of intraoperative radiation therapy. The technique was designed in 1998 at the University College London.
Worldwide, breast cancer is the most common invasive cancer in women. Breast cancer comprises 22.9% of invasive cancers in women and 16% of all female cancers.
The association between obesity, as defined by a body mass index of 30 or higher, and risk of a variety of types of cancer has received a considerable amount of attention in recent years. Obesity has been associated with an increased risk of esophageal cancer, pancreatic cancer, colorectal cancer, breast cancer, endometrial cancer, kidney cancer, thyroid cancer, liver cancer and gallbladder cancer. Obesity may also lead to increased cancer-related mortality. Obesity has also been described as the fat tissue disease version of cancer, where common features between the two diseases were suggested for the first time.
Roel Vermeulen is a Dutch scientist and professor at Utrecht University and University Medical Center Utrecht, the Netherlands in the field of environmental epidemiology and exposome. His scientific research focuses on environmental risk factors for cancer and neurological diseases, with a strong emphasis on the integration of epidemiology, high-quality exposure assessment and molecular biology in multidisciplinary studies.
Francine Laden is an American epidemiologist who is Professor of Environmental Epidemiology at the Harvard T.H. Chan School of Public Health. Her research has investigated the environmental epidemiology of chronic disease. She serves as co-director of the Harvard University and Boston University center for research on environmental and social stressors in housing across the life course. Laden has also served on the United States Environmental Protection Agency advisory board.
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