Molybdopterin synthase sulfurtransferase

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Molybdopterin synthase sulfurtransferase
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EC no. 2.8.1.11
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Molybdopterin synthase sulfurtransferase (EC 2.8.1.11, adenylyltransferase and sulfurtransferase MOCS3, Cnx5 (gene), molybdopterin synthase sulfurylase) is an enzyme with systematic name persulfurated L-cysteine desulfurase:(molybdopterin-synthase sulfur-carrier protein)-Gly-Gly sulfurtransferase. [1] [2] [3] [4] This enzyme catalyses the following chemical reaction

[molybdopterin-synthase sulfur-carrier protein]-Gly-Gly-AMP + [cysteine desulfurase]-S-sulfanyl-L-cysteine AMP + [molybdopterin-synthase sulfur-carrier protein]-Gly-NH-CH2-C(O)SH + cysteine desulfurase

The enzyme transfers sulfur to form a thiocarboxylate moiety on the C-terminal glycine of the small subunit of molybdopterin synthase.

Related Research Articles

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<span class="mw-page-title-main">Lipoyl synthase</span>

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Adenylyltransferase and sulfurtransferase MOCS3 is an enzyme that in humans is encoded by the MOCS3 gene.

Molybdopterin synthase (EC 2.8.1.12, MPT synthase) is an enzyme required to synthesize molybdopterin (MPT) from precursor Z (now known as cyclic pyranopterin monophosphate). Molydopterin is subsequently complexed with molybdenum to form molybdenum cofactor (MoCo). MPT synthase catalyses the following chemical reaction:

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Molybdenum cofactor cytidylyltransferase is an enzyme with systematic name CTP:molybdenum cofactor cytidylyltransferase. This enzyme catalyses the following chemical reaction:

Molybdenum cofactor guanylyltransferase is an enzyme with systematic name GTP:molybdenum cofactor guanylyltransferase. This enzyme catalyses the following chemical reaction:

Molybdopterin-synthase adenylyltransferase is an enzyme with systematic name ATP:molybdopterin-synthase adenylyltransferase. This enzyme catalyses the following chemical reaction

Molybdenum cofactor sulfurtransferase (EC 2.8.1.9, molybdenum cofactor sulfurase, ABA3, MoCo sulfurase, MoCo sulfurtransferase) is an enzyme with systematic name L-cysteine:molybdenum cofactor sulfurtransferase. This enzyme catalyses the following chemical reaction

<span class="mw-page-title-main">Thiazole synthase</span>

Thiazole synthase (EC 2.8.1.10, thiG (gene)) is an enzyme with systematic name 1-deoxy-D-xylulose 5-phosphate:thiol sulfurtransferase. This enzyme catalyses the following chemical reaction

Molybdopterin molybdotransferase is an enzyme with systematic name adenylyl-molybdopterin:molybdate molybdate transferase (AMP-forming). This enzyme catalyses the following chemical reaction

Cyclic pyranopterin monophosphate synthase is an enzyme with systematic name GTP 8,9-lyase . This enzyme catalyses the following chemical reaction

References

  1. Matthies A, Nimtz M, Leimkühler S (May 2005). "Molybdenum cofactor biosynthesis in humans: identification of a persulfide group in the rhodanese-like domain of MOCS3 by mass spectrometry". Biochemistry. 44 (21): 7912–20. doi:10.1021/bi0503448. PMID   15910006.
  2. Leimkühler S, Rajagopalan KV (June 2001). "A sulfurtransferase is required in the transfer of cysteine sulfur in the in vitro synthesis of molybdopterin from precursor Z in Escherichia coli". The Journal of Biological Chemistry. 276 (25): 22024–31. doi: 10.1074/jbc.M102072200 . PMID   11290749.
  3. Hänzelmann P, Dahl JU, Kuper J, Urban A, Müller-Theissen U, Leimkühler S, Schindelin H (December 2009). "Crystal structure of YnjE from Escherichia coli, a sulfurtransferase with three rhodanese domains". Protein Science. 18 (12): 2480–91. doi:10.1002/pro.260. PMC   2821267 . PMID   19798741.
  4. Dahl JU, Urban A, Bolte A, Sriyabhaya P, Donahue JL, Nimtz M, Larson TJ, Leimkühler S (October 2011). "The identification of a novel protein involved in molybdenum cofactor biosynthesis in Escherichia coli". The Journal of Biological Chemistry. 286 (41): 35801–12. doi:10.1074/jbc.M111.282368. PMC   3195606 . PMID   21856748.