Motretinide

Motretinide
Names
	IUPAC name N-Ethyl-3-methoxy-2-methyl-1,2,3,4-tetradehydro-17-norretinamide
	Systematic IUPAC name (2E,4E,6E,8E)-N-Ethyl-8-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethylnona-2,4,6,8-tetraenamide
Identifiers
CAS Number	56281-36-8 ;
3D model (JSmol)	Interactive image ;
ChemSpider	4880635 ;
ECHA InfoCard	100.054.613
EC Number	260-094-6;
KEGG	D05082 ;
PubChem CID	6314185 ;
UNII	W786807KL1 ;
CompTox Dashboard (EPA)	DTXSID30878633 ;
	InChI InChI=1S/C23H31NO2/c1-8-24-23(25)14-17(3)11-9-10-16(2)12-13-21-18(4)15-22(26-7)20(6)19(21)5/h9-15H,8H2,1-7H3,(H,24,25)/b11-9+,13-12+,16-10+,17-14+ Key: IYIYMCASGKQOCZ-DJRRULDNSA-N ; InChI=1/C23H31NO2/c1-8-24-23(25)14-17(3)11-9-10-16(2)12-13-21-18(4)15-22(26-7)20(6)19(21)5/h9-15H,8H2,1-7H3,(H,24,25)/b11-9+,13-12+,16-10+,17-14+ Key: IYIYMCASGKQOCZ-DJRRULDNBU;
	SMILES CCNC(=O)/C=C(\C)/C=C/C=C(\C)/C=C/C1=C(C(=C(C=C1C)OC)C)C;
Properties
Chemical formula	C23H31NO2
Molar mass	353.49774
Pharmacology
ATC code	D10AD05 ( WHO )
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). verify (what is ?) Infobox references

Last updated January 01, 2026

Motretinide is an anti-acne preparation and aromatic analog of retinoic acid.^[1]

References

↑ Zouboulis, C. C. (2001). "Retinoids--which dermatological indications will benefit in the near future?". Skin Pharmacology and Applied Skin Physiology. 14 (5): 303–315. doi:10.1159/000056361. PMID 11586072.

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[1] Zouboulis, C. C. (2001). "Retinoids--which dermatological indications will benefit in the near future?". Skin Pharmacology and Applied Skin Physiology. 14 (5): 303–315. doi:10.1159/000056361. PMID 11586072.

[1]

v t e Acne-treating agents (D10)
Antibacterial	Azelaic acid Benzoyl peroxide ^# 8-Hydroxyquinoline Blue light therapy Tea tree oil
Keratolytic	Glycolic acid Salicylic acid ^# Sulfur Benzoyl peroxide ^#
Anti-inflammatory	Niacinamide Ibuprofen ^# Aspirin ^# Red light therapy
Antibiotics	Clindamycin Dapsone Erythromycin Sulfacetamide Tetracyclines (Lymecycline Minocycline Doxycycline)
Hormonal	Antiandrogens Bicalutamide Cyproterone acetate Drospirenone Flutamide Spironolactone) Estrogens Estradiol Ethinylestradiol
Retinoids	Adapalene Isotretinoin Motretinide Tazarotene Tretinoin Trifarotene
Other	Epristeride Mesulfen Pelretin Stridex Tioxolone
Combinations	Adapalene/benzoyl peroxide Clindamycin/adapalene/benzoyl peroxide Clindamycin/benzoyl peroxide Clindamycin/tretinoin Erythromycin/benzoyl peroxide Erythromycin/isotretinoin Sulfacetamide/sulfur Tretinoin/benzoyl peroxide
^# WHO-EM ^‡ Withdrawn from market Clinical trials: ^† Phase III ^§Never to phase III

Names

IUPAC name N-Ethyl-3-methoxy-2-methyl-1,2,3,4-tetradehydro-17-norretinamide
Systematic IUPAC name (2E,4E,6E,8E)-N-Ethyl-8-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethylnona-2,4,6,8-tetraenamide
Identifiers
CAS Number	56281-36-8 ^Y
3D model (JSmol)	Interactive image
ChemSpider	4880635 ^N
ECHA InfoCard	100.054.613
EC Number	260-094-6
KEGG	D05082 ^N
PubChem CID	6314185
UNII	W786807KL1 ^Y
CompTox Dashboard (EPA)	DTXSID30878633
InChI InChI=1S/C23H31NO2/c1-8-24-23(25)14-17(3)11-9-10-16(2)12-13-21-18(4)15-22(26-7)20(6)19(21)5/h9-15H,8H2,1-7H3,(H,24,25)/b11-9+,13-12+,16-10+,17-14+^N Key: IYIYMCASGKQOCZ-DJRRULDNSA-N^N InChI=1/C23H31NO2/c1-8-24-23(25)14-17(3)11-9-10-16(2)12-13-21-18(4)15-22(26-7)20(6)19(21)5/h9-15H,8H2,1-7H3,(H,24,25)/b11-9+,13-12+,16-10+,17-14+ Key: IYIYMCASGKQOCZ-DJRRULDNBU
SMILES CCNC(=O)/C=C(\C)/C=C/C=C(\C)/C=C/C1=C(C(=C(C=C1C)OC)C)C
Properties
Chemical formula	C₂₃H₃₁NO₂
Molar mass	353.49774
Pharmacology
ATC code	D10AD05 ( WHO )
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). N verify (what is ^YN ?) Infobox references