 | |
| Names | |
|---|---|
| Preferred IUPAC name 1-(2-{[(Diphenylmethylidene)amino]oxy}ethyl)-1,2,5,6-tetrahydropyridine-3-carboxylic acid | |
| Other names NO-711 | |
| Identifiers | |
3D model (JSmol) | |
| ChemSpider | |
PubChem CID | |
| UNII | |
CompTox Dashboard (EPA) | |
| |
| |
| Properties | |
| C21H22N2O3 | |
| Molar mass | 350.418 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
NNC-711 is an anticonvulsant, acting as a gamma-aminobutyric acid uptake inhibitor via inhibition of GAT-1. [1]
G.711 is a narrowband audio codec originally designed for use in telephony that provides toll-quality audio at 64 kbit/s. It is an ITU-T standard (Recommendation) for audio encoding, titled Pulse code modulation (PCM) of voice frequencies released for use in 1972.
Torness nuclear power station is a nuclear power station located approximately 30 miles (50 km) east of Edinburgh at Torness Point near Dunbar in East Lothian, Scotland. It was the last of the United Kingdom's Advanced Gas-cooled Reactors to be fully commissioned. Construction of this facility began in 1980 for the then South of Scotland Electricity Board (SSEB) and it was commissioned in 1988. It is a local landmark, highly visible from the A1 trunk road and East Coast Main Line railway.
The Naga conflict, also known as the Naga Insurgency, is an ongoing conflict fought between the ethnic Nagas and the governments of India in northeastern India. Nagaland, inhabited by the Nagas, is located at the tri-junction border of India on the West and South, north and Myanmar on the East.
Levormeloxifene is a selective estrogen receptor modulator (SERM) which was being developed as an alternative to estrogen replacement therapy for the treatment and prevention of postmenopausal bone loss but did not complete development and hence was never marketed. The development was stopped because of a high incidence of gynecological side effects during clinical trials. Levormeloxifene is the levorotatory enantiomer of ormeloxifene, which, in contrast, has been marketed, though rather as a hormonal contraceptive.
The Natal Native Contingent was a large force of auxiliary soldiers in British South Africa, forming a substantial portion of the defence forces of the British colony of Natal. The Contingent saw action during the 1879 Anglo-Zulu War. The Natal Mounted Police was created in 1873 to bolster the defenses of Natal. It enlisted European officers, NCOs and natives. The infantry was created in 1878. Most enlisted troops were drawn from the Basuto and Mpondo tribes, which had had long experience fighting the Zulus.
National Nutrition Council, abbreviated as NNC, is an agency of the Philippine government under the Department of Health responsible for creating a conducive policy environment for national and local nutrition planning, implementation, monitoring and evaluation, and surveillance using state-of the art technology and approaches.
The 1918 Florida Gators football team represented the University of Florida during the 1918 college football season. The season was the second for Alfred L. Buser as Florida's head coach. The Gators' ranks were depleted by the Spanish flu and the loss of World War I military volunteers and draftees, and Florida played only one game—a 2–14 loss to a football team from Camp Johnston, a U.S. Army training installation in nearby Jacksonville, Florida. Buser's Gators did not play a Southern Intercollegiate Athletic Association (SIAA) conference schedule in 1918.
Mark Merklein is a Bahamian former college and professional tennis player. He played for the Bahamas Davis Cup team from 1999–2004.
Femoxetine is a drug related to paroxetine that was being developed as an antidepressant by Danish pharmaceutical company Ferrosan in 1975 before acquisition of the company by Novo Nordisk. It acts as a selective serotonin reuptake inhibitor (SSRI). Development was halted to focus attention on paroxetine instead, as femoxetine could not be administered as a daily pill.
The Naga National Council (NNC) was a political organization of Naga people, active from the late 1940s to the early 1950s. It evolved out of the Naga Hills District Tribal Council, an organization established in 1945 by the Deputy Commissioner of the Naga Hills district. The group was reorganized to form NNC in 1946 at Sanis, with Eno T. Aliba Imti Ao as the President, and other democratically elected Naga representatives as its members. NNC declared independence a day before India's independence on 14 August 1947, and unsuccessfully campaigned for the secession of the Naga territory from India.
NNC 63-0532 is a nociceptoid drug used in scientific research. It acts as a potent and selective agonist for the nociceptin receptor, also known as the ORL-1 receptor.
A GABA reuptake inhibitor (GRI) is a type of drug which acts as a reuptake inhibitor for the neurotransmitter gamma-Aminobutyric acid (GABA) by blocking the action of the gamma-Aminobutyric acid transporters (GATs). This in turn leads to increased extracellular concentrations of GABA and therefore an increase in GABAergic neurotransmission. Gamma-aminobutyric acid (GABA) is an amino acid that functions as the predominant inhibitory neurotransmitter within the central nervous system, playing a crucial role in modulating neuronal activity in both the brain and spinal cord. While GABA predominantly exerts inhibitory actions in the adult brain, it has an excitatory role during developmental stages. When the neuron receives the action potential, GABA is released from the pre-synaptic cell to the synaptic cleft. After the action potential transmission, GABA is detected on the dendritic side, where specific receptors collectively contribute to the inhibitory outcome by facilitating GABA transmitter uptake. Facilitated by specific enzymes, GABA binds to post-synaptic receptors, with GABAergic neurons playing a key role in system regulation. The inhibitory effects of GABA diminish when presynaptic neurons reabsorb it from the synaptic cleft for recycling by GABA transporters (GATs). The reuptake mechanism is crucial for maintaining neurotransmitter levels and synaptic functioning. Gamma-aminobutyric acid Reuptake Inhibitors (GRIs) hinder the functioning of GATs, preventing GABA reabsorption in the pre-synaptic cell. This results in increased GABA levels in the extracellular environment, leading to elevated GABA-mediated synaptic activity in the brain.
The Shillong Accord of 1975 was an agreement signed between the Government of India, also referred to as the Federal government, or Union government, or Central government of India, and Nagaland's underground government, also referred to as the Naga Federal government, or Naga guerillas, or Naga rebels, to accept the supremacy of Constitution of India without condition, surrender their arms and renounce their demand for the secession of Nagaland from India.
New South Wales North Coast or NSW North Coast, an interim Australian bioregion, is located in New South Wales, comprising 3,996,591 hectares.
CI-966 (developmental code name) is a central nervous system depressant acting as a GABA reuptake inhibitor, specifically a highly potent and selective blocker of the GABA transporter 1 (GAT-1) (IC50 = 0.26 μM), and hence indirect and non-selective GABA receptor full agonist. It was investigated as a potential anticonvulsant, anxiolytic, and neuroprotective therapeutic but was discontinued during clinical development due to the incidence of severe adverse effects at higher doses and hence was never marketed.
SKF-89976A is an anticonvulsant, acting as a GABA reuptake inhibitor via blockade of GAT-1.
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NC 45-0095 is a synthetic nonsteroidal selective estrogen receptor modulator (SERM) which was under development by Novo Nordisk for the treatment of postmenopausal osteoporosis but was never marketed. It is a partial agonist of the estrogen receptor (IC50Tooltip half-maximal inhibitory concentration (for binding inhibition) = 9.5 nM; EC50Tooltip half-maximal effective concentration = 13 nM) with mixed estrogenic and antiestrogenic activity, and shows full estrogenic activity in bone and uterus (EmaxTooltip maximal efficacy (relative to moxestrol, in Ishikawa endometrial cancer cell line) = 105%). The compound is a pyrroloindolizine derivative. Its development was discontinued by 2003.
Nurture Nature Center (NNC) is a science-based education center focused on engaging the public on environmental risk topics. NNC is located in the city of Easton, Pennsylvania, roughly 55 miles north of Philadelphia and 70 miles west of New York City. It was founded by Theodore W. Kheel in response to flooding in 2004, 2005, and 2006 in the Delaware River Basin. The center's work today encompasses both national social science research and local community programming.
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