NNC-711

Last updated
NNC-711
NO-711.svg
Names
Preferred IUPAC name
1-(2-{[(Diphenylmethylidene)amino]oxy}ethyl)-1,2,5,6-tetrahydropyridine-3-carboxylic acid
Other names
NNC711; NO-711; NO711
Identifiers
3D model (JSmol)
ChemSpider
PubChem CID
UNII
  • InChI=1S/C21H22N2O3/c24-21(25)19-12-7-13-23(16-19)14-15-26-22-20(17-8-3-1-4-9-17)18-10-5-2-6-11-18/h1-6,8-12H,7,13-16H2,(H,24,25)
    Key: NGNALWDRPKNJGR-UHFFFAOYSA-N
  • C1CN(CC(=C1)C(=O)O)CCON=C(C2=CC=CC=C2)C3=CC=CC=C3
Properties
C21H22N2O3
Molar mass 350.418 g·mol−1
Pharmacology
Drug class GABA reuptake inhibitor; GABA transporter 1 (GAT-1) inhibitor; Anticonvulsant
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

NNC-711 is an anticonvulsant, acting as a GABA reuptake inhibitor via inhibition of GAT-1. [1] [2]

References

  1. ↑ Borden, L. A.; Murali Dhar, T. G.; Smith, K. E.; Weinshank, R. L.; Branchek, T. A.; Gluchowski, C (1994). "Tiagabine, SK&F 89976-A, CI-966, and NNC-711 are selective for the cloned GABA transporter GAT-1". European Journal of Pharmacology. 269 (2): 219–24. doi:10.1016/0922-4106(94)90089-2. PMID   7851497.
  2. ↑ Kubová, H. (December 1999). "NNC-711: An Inhibitor of GAB A Uptake with Selective Affinity to GAT-1". CNS Drug Reviews. 5 (4): 317–330. doi:10.1111/j.1527-3458.1999.tb00108.x.
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