Penicillium griseofulvum

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Penicillium griseofulvum
Scientific classification OOjs UI icon edit-ltr.svg
Domain: Eukaryota
Kingdom: Fungi
Division: Ascomycota
Class: Eurotiomycetes
Order: Eurotiales
Family: Aspergillaceae
Genus: Penicillium
Species:
P. griseofulvum
Binomial name
Penicillium griseofulvum
Dierckx, R.P. 1901 [1]
Type strain
CBS 185.27 [2]
Synonyms
  • Penicillium patulum
  • Penicillium urticae
  • Penicillium flexuosum
  • Penicillium maltum
  • Penicillium duninii [1]

Penicillium griseofulvum is a species of the genus of Penicillium which produces patulin, penifulvin A, cyclopiazonic acid, roquefortine C, shikimic acid, griseofulvin, [1] [2] and 6-Methylsalicylic acid (via a polyketide synthase). [3] [4] Penicillium griseofulvum occurs on cereals and nuts. [1] [2] [5] [6] [7] [8] [9]

Further reading

Related Research Articles

<i>Penicillium</i> Genus of fungi

Penicillium is a genus of ascomycetous fungi that is part of the mycobiome of many species and is of major importance in the natural environment, in food spoilage, and in food and drug production.

<span class="mw-page-title-main">Griseofulvin</span> Antifungal medication used for dermatophytoses

Griseofulvin is an antifungal medication used to treat a number of types of dermatophytoses (ringworm). This includes fungal infections of the nails and scalp, as well as the skin when antifungal creams have not worked. It is taken by mouth.

Shikimic acid, more commonly known as its anionic form shikimate, is a cyclohexene, a cyclitol and a cyclohexanecarboxylic acid. It is an important biochemical metabolite in plants and microorganisms. Its name comes from the Japanese flower shikimi, from which it was first isolated in 1885 by Johan Fredrik Eykman. The elucidation of its structure was made nearly 50 years later.

<i>Penicillium roqueforti</i> Species of fungus

Penicillium roqueforti is a common saprotrophic fungus in the genus Penicillium. Widespread in nature, it can be isolated from soil, decaying organic matter, and plants.

<i>Penicillium camemberti</i> Species of fungus

Penicillium camemberti is a species of fungus in the genus Penicillium. It is used in the production of Camembert, Brie, Langres, Coulommiers, and Cambozola cheeses, on which colonies of P. camemberti form a hard, white crust. It is responsible for giving these cheeses their distinctive flavors. An allergy to the antibiotic penicillin does not necessarily imply an allergy to cheeses made using P. camemberti.

<span class="mw-page-title-main">Citrinin</span> Chemical compound

Citrinin is a mycotoxin which is often found in food. It is a secondary metabolite produced by fungi that contaminates long-stored food and it causes different toxic effects, like nephrotoxic, hepatotoxic and cytotoxic effects. Citrinin is mainly found in stored grains, but sometimes also in fruits and other plant products.

<span class="mw-page-title-main">Shikimate pathway</span> Biosynthetic Pathway

The shikimate pathway is a seven-step metabolic pathway used by bacteria, archaea, fungi, algae, some protozoans, and plants for the biosynthesis of folates and aromatic amino acids. This pathway is not found in animal cells.

Medicinal fungi are fungi that contain metabolites or can be induced to produce metabolites through biotechnology to develop prescription drugs. Compounds successfully developed into drugs or under research include antibiotics, anti-cancer drugs, cholesterol and ergosterol synthesis inhibitors, psychotropic drugs, immunosuppressants and fungicides.

Penicillium brasilianum is a fungus species of the genus of Penicillium. Penicillium brasilianum produces the compounds isoroquefortine C, griseofulvin, ergosterol peroxide, 3β-hydroxy-(22E,24R)-ergosta-5,8,22-trien-7-one, cerevisterol, (22E,24R)-6β-methoxyergosta-7,22-diene-3β,5α-diol.

Penicillium citrinum is an anamorph, mesophilic fungus species of the genus of Penicillium which produces tanzawaic acid A-D, ACC, Mevastatin, Quinocitrinine A, Quinocitrinine B, and nephrotoxic citrinin. Penicillium citrinum is often found on moldy citrus fruits and occasionally it occurs in tropical spices and cereals. This Penicillium species also causes mortality for the mosquito Culex quinquefasciatus. Because of its mesophilic character, Penicillium citrinum occurs worldwide. The first statin (Mevastatin) was 1970 isolated from this species.

Penicillium corylophilum is a species of the genus of Penicillium which occurs in damp buildings in United States, Canada and western Europe but it can also be found in a variety of foods and mosquitoes. Penicillium corylophilum produces the alkaloid epoxyagroclavine and citrinin and is a pathogen to mosquitoes.

A species of the genus of Penicillium which causes Blue Mold of Garlic on Allium sativum L. The genus name is derived from the Latin root penicillum, meaning "painter's brush", and refers to the chains of conidia this fungus produces that resemble a broom.

Penicillium janczewskii is an anamorph and filamentous species of the genus of Penicillium which was isolated from the rhizosphere of Vernonia herbacea. Penicillium janczewskii produces griseofulvin

Penicillium nalgiovense is an anamorph species of the genus Penicillium with lipolytic and proteolytic activity, which was first isolated from ellischau cheese. This species produces dichlorodiaportin, diaportinol, and diaportinic acid Penicillium nalgiovense is used for the maturation of certain fermented salami varieties and ham. In this process it protects the meat from colonization by other molds and bacteria

Penicillium paneum is a species of fungus in the genus Penicillium which can spoil cereal grains. Penicillium paneum produces 1-Octen-3-ol and penipanoid A, penipanoid B, penipanoid C, patulin and roquefortine C

Penicillium persicinum is a species of fungus in the genus Penicillium which was isolated from soil from the Qinghai Province in China. Penicillium persicinum produces griseofulvin, lichexanthone, roquefortine C, roquefortine D, patulin and chrysogine

Penicillium pinophilum is a species of fungus in the genus Penicillium which was isolated from a radio set in Papua New Guinea. Penicillium pinophilum produces 3-O-methylfunicone and mycophenolic acid

Penicillium raistrickii is an anamorph species of fungus in the genus Penicillium which produces griseofulvin, patulin and verruculogen.

Penicillium thiersii is a species of fungus in the genus Penicillium which was isolated from a wood decay fungi (Hypoxylon) in Wisconsin in North America. Penicillium thiersii produces thiersindole A, thiersindole B, thiersindole C, oxalicine A and oxalicine B

Penicillium commune is an indoor fungus belonging to the genus Penicillium. It is known as one of the most common fungi spoilage moulds on cheese. It also grows on and spoils other foods such as meat products and fat-containing products like nuts and margarine. Cyclopiazonic acid and regulovasine A and B are the most important mycotoxins produced by P. commune. The fungus is the only known species to be able to produce both penitrem A and roquefortine. Although this species does not produce penicillin, it has shown to have anti-pathogenic activity. There are no known plant, animal or human diseases caused by P. commune.

References

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  2. 1 2 3 "Taxonomy - Penicillium griseofulvum". UniProt. Retrieved 13 June 2016.
  3. Anyaogu, Diana Chinyere; Mortensen, Uffe Hasbro (2015-02-10). "Heterologous production of fungal secondary metabolites in Aspergilli". Frontiers in Microbiology . Frontiers. 6: 77. doi: 10.3389/fmicb.2015.00077 . ISSN   1664-302X. PMC   4322707 . PMID   25713568.
  4. Atanasov, Atanas G.; Zotchev, Sergey B.; Dirsch, Verena M.; the International Natural Product Sciences Taskforce (Ilkay Erdogan Orhan, Maciej Banach, Judith M. Rollinger, Davide Barreca, Wolfram Weckwerth, Rudolf Bauer, Edward A. Bayer, Muhammed Majeed, Anupam Bishayee, Valery Bochkov, Günther K. Bonn, Nady Braidy, Franz Bucar, Alejandro Cifuentes, Grazia D’Onofrio, Michael Bodkin, Marc Diederich, Albena T. Dinkova-Kostova, Thomas Efferth, Khalid El Bairi, Nicolas Arkells, Tai-Ping Fan, Bernd L. Fiebich, Michael Freissmuth, Milen I. Georgiev, Simon Gibbons, Keith M. Godfrey, Christian W. Gruber, Jag Heer, Lukas A. Huber, Elena Ibanez, Anake Kijjoa, Anna K. Kiss, Aiping Lu, Francisco A. Macias, Mark J. S. Miller, Andrei Mocan, Rolf Müller, Ferdinando Nicoletti, George Perry, Valeria Pittalà, Luca Rastrelli, Michael Ristow, Gian Luigi Russo, Ana Sanches Silva, Daniela Schuster, Helen Sheridan, Krystyna Skalicka-Woźniak, Leandros Skaltsounis, Eduardo Sobarzo-Sánchez, David S. Bredt, Hermann Stuppner, Antoni Sureda, Nikolay T. Tzvetkov, Rosa Anna Vacca, Bharat B. Aggarwal, Maurizio Battino, Francesca Giampieri, Michael Wink, Jean-Luc Wolfender, Jianbo Xiao, Andy Wai Kan Yeung, Gérard Lizard, Michael A. Popp, Michael Heinrich, Ioana Berindan-Neagoe, Marc Stadler, Maria Daglia & Robert Verpoorte); Supuran, Claudiu T. (2021-01-28). "Natural products in drug discovery: advances and opportunities". Nature Reviews Drug Discovery . Nature Portfolio. 20 (3): 200–216. doi:10.1038/s41573-020-00114-z. ISSN   1474-1776. PMC   7841765 . PMID   33510482. ORCIDs: (AGA 0000-0003-2545-0967). (VMD 0000-0002-9261-5293). (CTS 0000-0003-4262-0323).{{cite journal}}: CS1 maint: multiple names: authors list (link)
  5. Spadaro, D.; Lorè, A.; Amatulli, M. T.; Garibaldi, A.; Gullino, M. L. (2011). "First Report of Penicillium griseofulvum Causing Blue Mold on Stored Apples in Italy (Piedmont)". Plant Disease. 95 (1): 76. doi:10.1094/PDIS-08-10-0568. PMID   30743679.
  6. Shim, S. H.; Swenson, D. C.; Gloer, J. B.; Dowd, P. F.; Wicklow, D. T. (2006). "Penifulvin A: A Sesquiterpenoid-Derived Metabolite Containing a Novel Dioxa[5,5,5,6]fenestrane Ring System from a Fungicolous Isolate of Penicillium griseofulvum". Organic Letters. 8 (6): 1225–8. doi:10.1021/ol060107c. PMID   16524309.
  7. John I. Pitt; Ailsa D. Hocking (2009). Fungi and Food Spoilage. Springer Science & Business Media. ISBN   978-0387922072.
  8. MacMillan, J. (1954). "Griseofulvin. Part IX. Isolation of the bromo-analogue from Penicillium griseofulvum and Penicillium nigricans". Journal of the Chemical Society (Resumed): 2585. doi:10.1039/JR9540002585.
  9. Simonart, P.; Wiaux, A. (1960). "Production of Shikimic Acid by Penicillium griseofulvum Dierckx". Nature. 186 (4718): 78–9. Bibcode:1960Natur.186...78S. doi:10.1038/186078a0. PMID   14446950. S2CID   4222847.