Poly(ADP-ribose) glycohydrolase

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Poly(ADP-ribose) glycohydrolase
Identifiers
EC no. 3.2.1.143
CAS no. 9068-16-0
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
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NCBI proteins

Poly(ADP-ribose) glycohydrolase (EC 3.2.1.143) is an enzyme. [1] [2] This enzyme catalyses the following chemical reaction

hydrolyses poly(ADP-ribose) at glycosidic (1''-2') linkage of ribose-ribose bond to produce free ADP-ribose

Specific to (1''-2') linkage of ribose-ribose bond of poly(ADP-ribose).

References

  1. Miwa M, Sugimura T (October 1971). "Splitting of the ribose-ribose linkage of poly(adenosine diphosphate-robose) by a calf thymus extract". The Journal of Biological Chemistry. 246 (20): 6362–4. doi: 10.1016/S0021-9258(18)61798-3 . PMID   4331388.
  2. Lin W, Amé JC, Aboul-Ela N, Jacobson EL, Jacobson MK (May 1997). "Isolation and characterization of the cDNA encoding bovine poly(ADP-ribose) glycohydrolase". The Journal of Biological Chemistry. 272 (18): 11895–901. doi: 10.1074/jbc.272.18.11895 . PMID   9115250.