Protostadienol synthase

Protostadienol synthase
Identifiers
EC no.	5.4.99.32
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

Protostadienol synthase (EC 5.4.99.32, PdsA, (S)-2,3-epoxysqualene mutase [cyclizing, (17Z)-protosta-17(20),24-dien-3beta-ol-forming]) is an enzyme with systematic name (3S)-2,3-epoxy-2,3-dihydrosqualene mutase (cyclizing, (17Z)-protosta-17(20),24-dien-3beta-ol-forming). ^[1] This enzyme catalyses the following chemical reaction

(3S)-2,3-epoxy-2,3-dihydrosqualene ${\displaystyle \rightleftharpoons }$ (17Z)-protosta-17(20),24-dien-3beta-ol

(17Z)-Protosta-17(20),24-dien-3beta-ol is a precursor of the steroidal antibiotic helvolic acid.

References

1. Lodeiro S, Xiong Q, Wilson WK, Ivanova Y, Smith ML, May GS, Matsuda SP (March 2009). "Protostadienol biosynthesis and metabolism in the pathogenic fungus Aspergillus fumigatus". Organic Letters. 11 (6): 1241–4. doi:10.1021/ol802696a. PMID   19216560.

External links

• Protostadienol+synthase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)