STK33

Last updated

STK33
Identifiers
Aliases STK33 , serine/threonine kinase 33
External IDs OMIM: 607670; MGI: 2152419; HomoloGene: 75307; GeneCards: STK33; OMA:STK33 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_054103
NM_001355145

RefSeq (protein)

NP_473444
NP_001342074

Location (UCSC) Chr 11: 8.39 – 8.59 Mb Chr 7: 108.88 – 109.04 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Serine/threonine kinase 33 is a protein that in humans is encoded by the STK33 gene.

STK33 was identified as a synthetic lethal gene in KRAS-dependent cell lines. [5]

STK33 has been considered as a target for reversible male contraceptives and the inhibitor CDD-2807 has been tested successfully in mice. [6]

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References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000130413 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000031027 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Spoonamore J, Weïwer M, Wei J, Guichard B, Ross NT, Masson K, et al. (2010). "Screen for Inhibitors of STK33 Kinase Activity". Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US). PMID   23658944.
  6. "Drug causes reversible male contraception in mice". 10 June 2024.