U.S. Route 321 (US 321) is a spur of U.S. Route 21. It runs for 516.9 miles (831.9 km) from Hardeeville, South Carolina to Lenoir City, Tennessee; with both serving as southern termini. It reaches its northernmost point at Elizabethton, Tennessee, just northeast of Johnson City. Because of its unusual "north–south–north" routing, U.S. Route 321 intersects both Interstate 40 and U.S. Route 70 three separate times. The highway serves different roles in each state: An alternate route to interstates in South Carolina, a major highway in North Carolina, and a scenic route in Tennessee.
U.S. Route 258 is a spur of US 58 in the U.S. states of North Carolina and Virginia. The U.S. Highway runs 220.15 miles (354.30 km) from US 17 Business and NC 24 Business in Jacksonville, North Carolina north to Virginia State Route 143 at Fort Monroe in Hampton, Virginia. In North Carolina, US 258 connects Jacksonville with the Inner Banks communities of Kinston, Snow Hill, Farmville, Tarboro, and Murfreesboro. The U.S. Highway continues through the Virginia city of Franklin, where the highway intersects US 58, and the town of Smithfield on its way to the Hampton Roads metropolitan area. US 258 crosses the James River on the James River Bridge and follows Mercury Boulevard through Newport News and Hampton.
U.S. Route 264 (US 264) is an east–west United States Highway located completely within the U.S. state of North Carolina, running for 215.7 miles (347.1 km). Its western terminus is located at Interstate 87 (I-87), I-440, and US 64 in Raleigh. US 264 is a freeway between Raleigh and Wilson, with segments running concurrently with I-87, I-587, I-795, and US 64. The highway is largely parallel to I-587 between Wilson and Greenville and primarily serves smaller communities such as Saratoga and Farmville. East of Greenville, US 264 is an important highway connecting communities such as Washington, Belhaven, Swan Quarter, and Engelhard. The eastern terminus of US 264 is located at US 64 in Manns Harbor.
U.S. Route 220 (US 220) is a spur route of US 20. It runs in a north–south layout in the eastern United States, unlike its parent route as well as conventionally even-numbered highways, which run east-west. US 220 extends for 678 miles (1,091 km) from an intersection with US 1 in Rockingham, North Carolina, to its interchange with the Southern Tier Expressway in South Waverly, Pennsylvania. Some sections of the route are part of the Appalachian Development Highway System's Corridor O as well as I-73 in North Carolina. US 220 is designated as a spur route of US 20 but the route does not intersect US 20 or connect to other spurs of US 20.
U.S. Route 64 (US 64) is the longest numbered route in the U.S. state of North Carolina, running 604 miles (972 km) from the Tennessee state line to the Outer Banks. The route passes through the westernmost municipality in the state, Murphy, and one of the most easternmost municipalities, Manteo, making US 64 a symbolic representation of the phrase "from Murphy to Manteo" which is used to refer to the expanse of the state. The highway is a major east–west route through the central and eastern portion of the state.
Several special routes of U.S. Route 1 (US 1) exist, from Florida to Maine. In order from south to north, separated by type, these special routes are as follows.
U.S. Route 13 (US 13) runs along the Atlantic coastline for over 500 miles (800 km), passing through five states. Along its route, it possessed numerous special routes, which are all loops off the mainline US 13. At present, there are at least 15 special routes in existence: two in North Carolina, five in Virginia, two in Maryland, four in Delaware, and two in Pennsylvania. 13 others have existed in the past but have been deleted.
A total of at least 39 special routes of U.S. Route 17 (US 17) exist: 3 in Florida, 13 in South Carolina, 17 in North Carolina, and 6 in Virginia.
Several special routes of U.S. Route 23 (US 23) exist. There are 18 extant special routes along US 23 and 14 former routes.
U.S. Route 220 is a U.S. Highway that is a spur route of US 20. It runs from Rockingham, North Carolina, north to South Waverly, Pennsylvania. In the state of Pennsylvania, the route runs 248 miles (399 km) from the Maryland border in Cumberland Valley Township, Bedford County northeast to an interchange with Interstate 86 (I-86)/New York State Route 17 in South Waverly, Bradford County a short distance south of the New York border. Through the state, US 220 passes through the cities and towns of Bedford, Altoona, State College, Lock Haven, Williamsport, and Towanda. US 220 is concurrent with the entire completed Pennsylvania segment of I-99 between I-70/I-76 in Bedford and near I-80 near Bellefonte. US 220 is also a freeway around Bedford, along the I-80 concurrency between Bellefonte and Mill Hall, between Mill Hall and Jersey Shore, from the western end of Williamsport to near Halls, and near the New York border. The remainder of US 220 in Pennsylvania is mostly a two-lane surface road.
U.S. Route 220 is a north–south U.S. highway which travels from Rockingham, North Carolina, to South Waverly, Pennsylvania. In the U.S. state of North Carolina, US 220 travels 123.4 miles (198.6 km) from an intersection with US 1 in Rockingham to the Virginia state line near Price, North Carolina. The highway is an important north–south route in Central North Carolina, connecting Rockingham, Asheboro, Greensboro, and Summerfield. US 220 runs concurrently with Interstate 73 from north of Rockingham to Greensboro, and from Summerfield to Stokesdale; while US 220 runs concurrently with I-74 from Rockingham to Randleman.
Several special routes of U.S. Route 40 exist. In order from west to east they are as follows.
A total of at least five special routes of U.S. Route 322 currently exist.
Several special routes of U.S. Route 52 exist, from North Dakota to South Carolina. In order from northwest to southeast, they are as follows.
Several special routes of U.S. Route 30 exist. In order from west to east they are as follows.
Several special routes of U.S. Route 6 (US 6) exist. In order from west to east, these special routes are as follows.
Several special routes of U.S. Route 19 (US 19) exist. In order from south to north, they are as follows.
Several special routes of U.S. Route 29 (US 29) exist. In order from south to north, they are as follows.
Several special routes of U.S. Route 15 (US 15) exist. In order from south to north, they are as follows.
Eighteen special routes of U.S. Route 58 currently exist in Virginia. In order from west to east they are as follows:
