Stiefel Laboratories

Last updated
Stiefel Laboratories Inc.
Type Subsidiary
Industry Pharmaceuticals
Founded1847;177 years ago (1847), in Germany
FounderJohn David Stiefel
Headquarters
20 TW Alexander Drive
Research Triangle Park, North Carolina 27709
,
U.S.
Area served
Worldwide
Key people
Simon Jose, President
Parent GSK plc
Website www.stiefel.com
Global headquarters, Research Triangle Park, North Carolina Stiefel, a GSK company headquarters.jpg
Global headquarters, Research Triangle Park, North Carolina

Stiefel Laboratories Inc. is an American dermatological pharmaceutical company, with its global headquarters in Research Triangle Park, North Carolina. [1] It makes products such as Duac and Oilatum. [2] Stiefel was acquired by GSK plc at a price of $2.9 billion. [3] [4] The company was founded in 1847 by John David Stiefel, Ferdinand von Hebra and Paul Unna, who initially created medicated soaps. [5]

Contents

Early history

The company's origins lie in the J.D. Stiefel Company which was established in 1847, in Germany, by John David Stiefel; its first products were candles but the company began making medicated soaps within several years of its founding. In the 1880s, the company began worldwide export of its products. [6]

The company's products were brought to the United States for the first time by August C. Stiefel, the grandson of J.D. Stiefel (the founder), in 1910 and named the company Stiefel Medicinal Soap Co., Inc. [6]

By 1914, Stiefel produced 103 different toilet, perfumed, and medicinal soaps and were packaged in seven different languages. [6]

One of J.D. Stiefel Company's original products in the 1920s, was called Stiefel Freckle Soap. In early advertisements, Freckle Soap claimed to wash "freckles and unsightly tan" away. At this time, soaps were packaged in tins to prolong the product's shelf life. [6]

1940s-1960s

In 1947 the business was resurrected, and registered in the State of New York under the name the Stiefel Medicinal Soap Company, Inc., initially operating from a former creamery in Oak Hill, New York. As the product line grew and diversified beyond medicinal soaps, the company was renamed Stiefel Laboratories, Inc. [7]

In 1948, the Stiefel Medicinal Soap Company worked with dermatologists to develop the Oilatum family of products, which treat dry skin and atopic dermatitis. [7]

In 1959, Zeasorb has the ability to absorb six times its weight in moisture. Stiefel developed Zeasorb products with dermatologists, who identified the need for such a powder.

Introduced in 1960, Polytar first featured the combination of tars in a shampoo. [7]

In 1966, Stiefel introduced the first benzoyl peroxide product for acne—Sulfoxyl Lotion (5% benzoyl peroxide, 2% sulfur). The treatment was introduced to Canadian dermatologists as BenOxyl Lotion. [7]

As the Stiefel Medicinal Soap Company's product line grew and diversified beyond medicinal soaps, the company name was changed to Stiefel Laboratories, Inc. At that time, all production was done at the Oak Hill, New York, facility. Eventually its network of distributors, subsidiaries and manufacturing facilities in other countries allowed the company to manufacture and distribute products around the globe. During the 1960s, sales and manufacturing operations expanded to include Canada, Puerto Rico, Germany, Hong Kong, the United Kingdom, Costa Rica, the Philippines, Ireland and other locations. By 1969, non-US international sales had reached $200,000.

1970s-2000

In the 1970s, the company expanded into South and Central America, the Caribbean, and France. The distributorship in Canada became a subsidiary, and manufacturing operations began in Sligo, Ireland. Between 1970 and 1979, the company averaged fifty percent growth every year and sales grew to $10.4 million. [7]

In 1977, the headquarters were relocated to Coral Gables, Florida. [7]

During the 1980s, Stiefel's first research and development facility outside of the US was established in 1985 in Slough, a town near the company's United Kingdom headquarters. It was later moved to Maidenhead. [8]

Another R&D facility was established in Brazil. At the close of the 1980s international sales had grown to nearly $50 million. The company's operations continued to expand and by the 1990s Stiefel Laboratories had subsidiaries in more than 30 countries and relationships with distributors in 70 others. By the end of the decade, factories were operating in Ireland, Brazil, Singapore and Mexico, supplying markets around the world. Sales had reached $180 million. [8]

In 1991, Stiefel Laboratories founded Glades Pharmaceuticals to market generic dermatology products. Glades Pharmaceuticals later matured to market a full line of products including branded-generic and branded products. Brevoxyl/Solugel Creamy Wash is launched as the first benzoyl peroxide product containing dimethyl isosorbide to dissolve the benzoyl peroxide crystals and reduce irritation. [8]

2000 onward

In 2000, Stiefel Introduced Physiogel, a brand of skin care products. [8]

In 2006, Stiefel Laboratories made its first major corporate acquisition when it acquired California-based Connetics Corporation, a specialty pharmaceutical company focused on the development and commercialization of innovative therapeutics for the dermatology market. [8] [9]

In 2007, Revaléskin was introduced formulated with the antioxidant ingredient, CoffeeBerry. [8]

William D. (Bill) Humphries was promoted to president of Stiefel Laboratories, Inc., the privately held dermatology company in 2008. An acquisition of Barrier Therapeutics, Inc. ("Barrier Therapeutics") on August 6, 2008 was also completed. [10]

Stiefel was acquired by GlaxoSmithKline in July 2009 to create a new specialist dermatology business. As part of the acquisition, Stiefel Laboratories is now branded "Stiefel, a GSK company" in advertising. [11]

Stiefel launched MaxClarity [12] and received FDA approval of two Rx products in the United States, [13] Sorilux Foam and Veltin Gel in 2010.

In 2012, customers began to have trouble sourcing Stiefel's popular anti-acne treatment, PanOxyl.

In 2013, GSK discontinued the UK version of Stiefel's popular skin drying treatment, Zeasorb.

Related Research Articles

<span class="mw-page-title-main">Acne</span> Skin condition characterized by pimples

Acne, also known as acne vulgaris, is a long-term skin condition that occurs when dead skin cells and oil from the skin clog hair follicles. Typical features of the condition include blackheads or whiteheads, pimples, oily skin, and possible scarring. It primarily affects skin with a relatively high number of oil glands, including the face, upper part of the chest, and back. The resulting appearance can lead to lack of confidence, anxiety, reduced self-esteem, and, in extreme cases, depression or thoughts of suicide.

<span class="mw-page-title-main">GSK plc</span> British multinational pharmaceutical and biotechnology company

GSK plc is a British multinational pharmaceutical and biotechnology company with global headquarters in London. Established in 2000 by a merger of Glaxo Wellcome and SmithKline Beecham, GSK is the tenth largest pharmaceutical company and #294 on the 2022 Fortune Global 500, ranked behind other pharmaceutical companies China Resources, Sinopharm, Johnson & Johnson, Pfizer, Roche, AbbVie, Novartis, Bayer, and Merck Sharp & Dohme.

<span class="mw-page-title-main">Benzoyl peroxide</span> Chemical compound with uses in industry and acne treatment

Benzoyl peroxide is a chemical compound (specifically, an organic peroxide) with structural formula (C6H5−C(=O)O−)2, often abbreviated as (BzO)2. In terms of its structure, the molecule can be described as two benzoyl (C6H5−C(=O)−, Bz) groups connected by a peroxide (−O−O−). It is a white granular solid with a faint odour of benzaldehyde, poorly soluble in water but soluble in acetone, ethanol, and many other organic solvents. Benzoyl peroxide is an oxidizer, which is principally used as in the production of polymers.

<span class="mw-page-title-main">Adapalene</span> Third-generation topical retinoid

Adapalene is a third-generation topical retinoid primarily used in the treatment of mild-moderate acne, and is also used off-label to treat keratosis pilaris as well as other skin conditions. Studies have found adapalene is as effective as other retinoids, while causing less irritation. It also has several advantages over other retinoids. The adapalene molecule is more stable compared to tretinoin and tazarotene, which leads to less concern for photodegradation. It is also chemically more stable compared to the other two retinoids, allowing it to be used in combination with benzoyl peroxide. Due to its effects on keratinocyte proliferation and differentiation, adapalene is superior to tretinoin for the treatment of comedonal acne and is often used as a first-line agent. The Swiss company Galderma sells adapalene under the brand-name product Differin.

<span class="mw-page-title-main">Comedo</span> Medical condition

A comedo is a clogged hair follicle (pore) in the skin. Keratin combines with oil to block the follicle. A comedo can be open (blackhead) or closed by skin (whitehead) and occur with or without acne. The word "comedo" comes from the Latin comedere, meaning "to eat up", and was historically used to describe parasitic worms; in modern medical terminology, it is used to suggest the worm-like appearance of the expressed material.

<span class="mw-page-title-main">Proactiv</span> Acne focused skincare products

Proactiv is an American brand of skin-care products developed by two American dermatologists, Katie Rodan and Kathy A. Fields, and launched in 1995 by Guthy-Renker, a California-based direct marketing company, that was endorsed by famous celebrities The range includes moisturizers, body washes and treatment products, but the brand is known for its three-step anti-acne Solutions 3-step routine consisting of a BPO cleanser, glycolic toner and treatment lotion. Proactiv+, a reformulation of the three-step kit, was introduced in 2013, and in 2017, ProactivMD launches powered by Adapalene.

<span class="mw-page-title-main">Clindamycin/benzoyl peroxide</span> Type of medication

Clindamycin/benzoyl peroxide is a topical gel used for the treatment of acne. It is a fixed-dose combination of clindamycin, as the phosphate, an antibiotic, and benzoyl peroxide, an antiseptic.

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Benzamycin is a topical gel containing of 5% benzoyl peroxide and 3% erythromycin. Its main usage is to fight acne. Benzamycin is a prescription medication.

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<span class="mw-page-title-main">Pimple</span> Type of comedo

A pimple or zit is a kind of comedo that results from excess sebum and dead skin cells getting trapped in the pores of the skin. In its aggravated state, it may evolve into a pustule or papule. Pimples can be treated by acne medications, antibiotics, and anti-inflammatories prescribed by a physician, or various over the counter remedies purchased at a pharmacy.

GlaxoSmithKline Pharmaceuticals Ltd is an Indian research-based pharmaceutical and healthcare company, and a subsidiary of GSK. The company's product portfolio includes prescription medicines and vaccines. Its prescription medicines range across therapeutic areas such as anti-infectives, dermatology, gynaecology, diabetes, oncology, cardiovascular disease and respiratory diseases. It also offers a range of vaccines, for the prevention of hepatitis A, hepatitis B, invasive disease caused by H, influenzae, chickenpox, diphtheria, pertussis, tetanus, rotavirus, cervical cancer and others.

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References

  1. "Stiefel, a GSK company – Contact Us". Stiefel.com. Retrieved 2011-12-14.
  2. "Stiefel, a GSK company - Product Websites". Stiefel.com. Retrieved 2011-12-14.
  3. Kelley, Trista (2009-04-20). "Glaxo to Buy Stiefel for $2.9 Billion, Add Skin Drugs (Update4)". Bloomberg. Retrieved 2011-12-14.
  4. "GlaxoSmithKline and Stiefel to create new world-leading specialist dermatology business". Gsk.com. 2009-07-31. Retrieved 2011-12-14.
  5. "Stiefel, a GSK company - History". Stiefel.com. Retrieved 2011-12-14.
  6. 1 2 3 4 "Stiefel, a GSK company- History 1847 - 1946". Stiefel.com. Retrieved 2011-12-14.
  7. 1 2 3 4 5 6 "Stiefel, a GSK company- History 1947 - 1979". Stiefel.com. Retrieved 2011-12-14.
  8. 1 2 3 4 5 6 "Stiefel, a GSK company – History 1980 - Present". Stiefel.com. 2008-08-06. Retrieved 2011-12-14.
  9. Business Wire (2006-10-23). "Connetics Corporation and Stiefel Laboratories, Inc. Sign Definitive Merger Agreement". Business Wire. Retrieved 2011-12-14.{{cite web}}: |author= has generic name (help)
  10. "Stiefel Labs Goes Outside Founding Family in Choice for President". WRAL Tech Wire. 2008-03-03. Retrieved 2011-12-14.
  11. "GlaxoSmithKline completes acquisition of Stiefel". Gsk.com. Retrieved 2011-12-14.
  12. "Stiefel, a GSK Company, Brings Acne Innovation Directly to Consumers with... - RESEARCH TRIANGLE PARK, N.C., July 27 /PRNewswire/". North Carolina: Prnewswire.com. Retrieved 2011-12-14.
  13. "Stiefel, a GSK company – Press Releases". Stiefel.com. 2010-10-12. Retrieved 2011-12-14.