| Streptomyces hygroscopicus | |
|---|---|
 | |
| Streptomyces hygroscopicus colonies | |
Scientific classification  | |
| Domain: | Bacteria |
| Phylum: | Actinomycetota |
| Class: | Actinomycetia |
| Order: | Streptomycetales |
| Family: | Streptomycetaceae |
| Genus: | Streptomyces |
| Species: | S. hygroscopicus |
| Binomial name | |
| Streptomyces hygroscopicus (Jensen, 1931) Yüntsen et al., 1956 [1] | |
| Subspecies | |
| |
| Synonyms [2] | |
| |
Streptomyces hygroscopicus is a bacterial species in the genus Streptomyces . It was first described by Hans Laurits Jensen in 1931. [3]
Cultures of different strains of S. hygroscopicus can be used to produce several chemical compounds or enzymes.
Sirolimus (also known as rapamycin) is an immunosuppressant that has been isolated from S. hygroscopicus from soil samples from Easter Island. [4] Ascomycin can be used to treat autoimmune diseases and skin diseases and can help prevent rejection after an organ transplant.
The antibiotics geldanamycin, hygromycin B, nigericin, validamycin, and cyclothiazomycin are found in S. hygroscopicus.
Indolocarbazoles can be found in S. hygroscopicus .
Milbemycin and milbemycin oxime can be found in S. hygroscopicus cultures.
S. hygroscopicus also produces the natural herbicide bialaphos. [5]
The enzymes alpha,alpha-trehalose-phosphate synthase (GDP-forming), carboxyvinyl-carboxyphosphonate phosphorylmutase, and hygromycin-B kinase can be isolated from cultures of S. hygroscopicus.
Streptomyces is the largest genus of Actinomycetota, and the type genus of the family Streptomycetaceae. Over 700 species of Streptomyces bacteria have been described. As with the other Actinomycetota, streptomycetes are gram-positive, and have very large genomes with high GC content. Found predominantly in soil and decaying vegetation, most streptomycetes produce spores, and are noted for their distinct "earthy" odor that results from production of a volatile metabolite, geosmin. Different strains of the same species may colonize very diverse environments.
Clavulanic acid is a β-lactam drug that functions as a mechanism-based β-lactamase inhibitor. While not effective by itself as an antibiotic, when combined with penicillin-group antibiotics, it can overcome antibiotic resistance in bacteria that secrete β-lactamase, which otherwise inactivates most penicillins.
Lincosamides are a class of antibiotics, which include lincomycin, clindamycin, and pirlimycin.
Glufosinate is a naturally occurring broad-spectrum herbicide produced by several species of Streptomyces soil bacteria. Glufosinate is a non-selective, contact herbicide, with some systemic action. Plants may also metabolize bialaphos and phosalacine, other naturally occurring herbicides, directly into glufosinate. The compound irreversibly inhibits glutamine synthetase, an enzyme necessary for the production of glutamine and for ammonia detoxification, giving it antibacterial, antifungal and herbicidal properties. Application of glufosinate to plants leads to reduced glutamine and elevated ammonia levels in tissues, halting photosynthesis and resulting in plant death.
Hygromycin B is an antibiotic produced by the bacterium Streptomyces hygroscopicus. It is an aminoglycoside that kills bacteria, fungi and higher eukaryotic cells by inhibiting protein synthesis.
The genus Lysobacter belongs to the family Xanthomonadaceae within the Gammaproteobacteria and includes at least 46 named species, including: Lysobacter enzymogenes, L. antibioticus, L. gummosus, L. brunescens, L. defluvii, L. niabensis, L. niastensis, L. daejeonensis, L. yangpyeongensis, L. koreensis, L. concretionis, L. spongiicola, and L. capsici. Lysobacter spp. were originally grouped with myxobacteria because they shared the distinctive trait of gliding motility, but they uniquely display a number of traits that distinguish them from other taxonomically and ecologically related microbes including high genomic G+C content and the lack of flagella. The feature of gliding motility alone has piqued the interest of many, since the role of gliding bacteria in soil ecology is poorly understood. In addition, while a number of different mechanisms have been proposed for gliding motility among a wide range of bacterial species, the genetic mechanism in Lysobacter remains unknown. Members of the Lysobacter group have gained broad interest for production of extracellular enzymes. The group is also regarded as a rich source for production of novel antibiotics, such as β-lactams containing substituted side chains, macrocyclic lactams and macrocyclic peptide or depsipeptide antibiotics like the katanosins.
Streptomyces scabiei is a streptomycete bacterium species found in soils around the world. Unlike most of the 500 or so Streptomyces species it is a plant pathogen causing corky lesions to form on tuber and root crops as well as decreasing the growth of seedlings. Along with other closely related species it causes the potato disease common scab, which is an economically important disease in many potato growing areas. It was first described in 1892, being classified as a fungus, before being renamed in 1914 and again in 1948. Several other species of Streptomyces cause similar diseases to S. scabiei but other, more closely related species, do not.
Streptomyces isolates have yielded the majority of human, animal, and agricultural antibiotics, as well as a number of fundamental chemotherapy medicines. Streptomyces is the largest antibiotic-producing genus of Actinomycetota, producing chemotherapy, antibacterial, antifungal, antiparasitic drugs, and immunosuppressants. Streptomyces isolates are typically initiated with the aerial hyphal formation from the mycelium.
Streptomyces antibioticus is a gram-positive bacterium discovered in 1941 by Nobel-prize-winner Selman Waksman and H. Boyd Woodruff. Its name is derived from the Greek "strepto-" meaning "twisted", alluding to this genus' chain-like spore production, and "antibioticus", referring to this species' extensive antibiotic production. Upon its first characterization, it was noted that S. antibioticus produces a distinct soil odor.
Streptomyces lavendulae is a species of bacteria from the genus Streptomyces. It is isolated from soils globally and is known for its production of medically useful biologically active metabolites. To see a photo of this organism click here.
Streptomyces filipinensis is a bacterium species from the genus of Streptomyces which has been isolated from soil on the Philippines. Streptomyces filipinensis produces pentalenolactone I, hygromycin A and filipin.
Streptomyces galbus is a bacterium species from the genus of Streptomyces which has been isolated from soil from West Bengal. Streptomyces galbus produces xylanase, galbonolides A, galbonolides B and the actinomycin X complex.
Streptomyces griseoruber is a bacterium species from the genus of Streptomyces which has been isolated from soil in Japan. Streptomyces griseoruber produces beromycin, actinomycin D, gombapyrone A, gombapyrone B, gombapyrone C, gombapyrone D and rhodomycins
Streptomyces longisporoflavus is a bacterium species from the genus of Streptomyces which has been isolated from soil. Streptomyces longisporoflavus produces tetronasin and staurosporine.
Streptomyces microflavus is a bacterium species from the genus of Streptomyces which has been isolated from soil. Streptomyces microflavus produces nemadectin, fattiviracin A1, milbemycin and deoxyuridines. Streptomyces microflavus also produces the ionophore valinomycin. Streptomyces microflavus is also known to cause potato common scab disease in Korea.
Streptomyces milbemycinicus is a bacterium species from the genus of Streptomyces which has been isolated from soil. Streptomyces milbemycinicus produces milbemycin.
Streptomyces mutomycini is a bacterium species from the genus of Streptomyces which has been isolated from soil. Streptomyces mutomycini produces mutamycin. Cultures of different strains of S. hygroscopicus can be used to produce a number of chemical compounds or enzymes.
Streptomyces noboritoensis is a bacterium species from the genus of Streptomyces which has been isolated from soil in Japan. Streptomyces noboritoensis produces elasnin, noboritomycin A, noboritomycin B, blastomycin and hygromycin. Streptomyces noboritoensis also produces melanomycin, 1-hydroxysulffurmycin B and 5-hydroxymaltol.
Hygromycin A is a modified cinnamic acid flanked by a furanose sugar and aminocyclitol. It is produced by Streptomyces hygroscopicus, first described in the 1950s.
Cytochrome P450, family 107, also known as CYP107, is a cytochrome P450 monooxygenase family in bacteria, found to be conserved and highly populated in Streptomyces and Bacillus species. The first gene identified in this family is Cytochrome P450 eryF (CYP107A1) from Saccharopolyspora erythraea. Many enzymes of this family are involved in the synthesis of macrolide antibiotics. The members of this family are widely distributed in Alphaproteobacteria, cyanobacterial, Mycobacterium, Bacillota, and Streptomyces species, which may be due to horizontal gene transfer driven by selection pressure.
 | This Streptomyces-related article is a stub. You can help Wikipedia by expanding it. |