Succinate-semialdehyde dehydrogenase (acylating)

Succinate-semialdehyde dehydrogenase (acylating)
Identifiers
EC no.	1.2.1.76
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

Succinate-semialdehyde dehydrogenase (acylating) (EC 1.2.1.76, succinyl-coA reductase, coenzyme-A-dependent succinate-semialdehyde dehydrogenase) is an enzyme with systematic name succinate semialdehyde:NADP⁺ oxidoreductase (CoA-acylating). ^{[1] [2] [3]} This enzyme catalyses the following chemical reaction

succinate semialdehyde + CoA + NADP⁺${\displaystyle \rightleftharpoons }$ succinyl-CoA + NADPH + H⁺

Catalyses the NADPH-dependent reduction of succinyl-CoA to succinate semialdehyde.

References

1. Söhling B, Gottschalk G (February 1993). "Purification and characterization of a coenzyme-A-dependent succinate-semialdehyde dehydrogenase from Clostridium kluyveri". European Journal of Biochemistry. 212 (1): 121–7. doi: 10.1111/j.1432-1033.1993.tb17641.x . PMID   8444151.
2. Alber B, Olinger M, Rieder A, Kockelkorn D, Jobst B, Hügler M, Fuchs G (December 2006). "Malonyl-coenzyme A reductase in the modified 3-hydroxypropionate cycle for autotrophic carbon fixation in archaeal Metallosphaera and Sulfolobus spp" (PDF). Journal of Bacteriology. 188 (24): 8551–9. doi:10.1128/JB.00987-06. PMC   1698253 . PMID   17041055.
3. Berg IA, Kockelkorn D, Buckel W, Fuchs G (December 2007). "A 3-hydroxypropionate/4-hydroxybutyrate autotrophic carbon dioxide assimilation pathway in Archaea". Science. 318 (5857): 1782–6. Bibcode:2007Sci...318.1782B. doi:10.1126/science.1149976. PMID   18079405.

External links

• Succinate-semialdehyde+dehydrogenase+(acylating) at the U.S. National Library of Medicine Medical Subject Headings (MeSH)