TEKTIP1

Last updated
TEKTIP1
Identifiers
Aliases TEKTIP1 , chromosome 19 open reading frame 71, C19orf71, tektin bundle interacting protein 1
External IDs MGI: 1921072; HomoloGene: 47801; GeneCards: TEKTIP1; OMA:TEKTIP1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

100128569

432479

Ensembl

ENSG00000183397

ENSMUSG00000020234

UniProt

A6NCJ1

A6H6Q4

RefSeq (mRNA)

NM_001135580

NM_001014836

RefSeq (protein)

NP_001129052

NP_001014836

Location (UCSC) Chr 19: 3.54 – 3.54 Mb Chr 10: 81.2 – 81.2 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

TEKTIP1, also known as tektin-bundle interacting protein 1, is a protein that in humans is encoded by the TEKTIP1 gene. [5] [6]

Contents

Gene

Tektin bundle interacting protein 1 (TEKTIP1) is a protein which in humans is encoded by the TEKTIP1 mRNA. [5] The longest mRNA produced is 826 bases long. [7]

Aliases

Alias of the protein is C19orf71. [8]

Locus

The TEKTIP1 gene is located at 19p13.3. [9]

Transcriptional Regulation

Several predicted transcription factors may bind in the promoter region: TFDP1, PLAGL1, ZSCAN4, POU2F3. [10] [11] [12] [13] [14]

Chemical Interactions

Acrylamide, [15] cisplatin, [16] and silicon dioxide [17] decrease expression, while butanal (butyraldehyde), and pentanal increase expression [18] of TEKTIP1 mRNA.

Sequence orthology also suggests that valproic acid increases methylation of TEKTIP1 mRNA. [19]

Protein

The mRNA of TEKTIP1 is 654 nucleotides long. [5] [8] It contains five exons. [5] The human TEKTIP1 protein is 209 amino acids long and has a predicted molecular mass of 24.5 kDa. [8] The human protein has a theoretical isoelectric point of 9.1. [20]

Isoforms

There are two splice isoforms of the protein, X1 [21] and X2. [22]

X1 & X2 Isoform Orthologs
X1X2
Tibetan macaque [23] Chimpanzee [24]
Olive baboon [25] Olive baboon [26]
Panamanian white-faced capuchin [27] Common marmoset [28]
Golden [29] and Black [30]

snub-nosed monkeys

Golden sub-nosed monkey [31]
Elk [32] Elk [33]
Red deer [34] Red deer [35]
Greater horseshoe bat [36] Bats [37] [38] [39]
Red fox [40] Polar bear [41]

Characteristics & structure

TEKTIP1 is highly enriched in tryptophan and tyrosine. [42] Additionally, the protein is semi-enriched in arginine and proline. [43]

Expression

TEKTIP1 is tissue specific and is found in higher levels in the kidney, testis and thymus. [9]

In fetal development, it is found in higher levels in the Adrenal glands during weeks 16-20. [9]

TEKTIP1 protein is said to be specific to the testis and is found in early spermatids during spermatogenesis. [44]

Evolution

Orthologs

Over 240 organisms have orthologs with human gene TEKTIP1. [9] The most distant organism with an orthologous sequence to human TEKTIP1 is the West African lungfish (estimated date of divergence of 408 MYA). [45] [46]

Selected Orthologs for TEKTIP1
Genus and SpeciesCommon NameTaxonomic GroupMedian Date of Divergence (MYA)Accession #Sequence length (aa)Sequence Identity to Human Protein %Sequence Similarity to Human Protein %
Homo sapiens HumanPrimates/Hominidae0 NP_001129052.1 209100100
Pan troglodyte ChimpanzeePrimates6.4 XP_003316050.1 20998.198.6
Mus musculus MouseRodentia87 NP_001014836.2 21745.660.4
Bos taurus CowArtiodactyla94 NP_001070550 20876.684.2
Panthera tigris TigerCarnivora94 XP_042833719.1 21034.138.9
Orcinus orca Killer whaleCetacea94 XP_012394771.2 2166373.1
Phascolarctos cinereus KoalaDiprodontia160 XP_020824948.1 21152.967.4
Haliaeetus leucocephalus Bald EagleAccipitiformes319 XP_010580112.1 20641.452
Dromaius novaehollandiae EmuAves319 XP_025961204.1 19044.856.7
Gallus gallus domesticus ChickenAves319 XP_015155269.2 18838.248.4
Crocodylus porosus Saltwater CrocodileCrocodilia319 XP_019406144.1 21054.368.3
Caretta caretta Loggerhead Sea TurtleTestudines319 XP_048687032.1 21647.857.3
Zootoca vivipara Common lizardSquamata319 XP_034975173.1 20048.859.5
Crotalus tigris Tiger RattlesnakeSquamata319 XP_039190693.1 19945.857.5
Protobothrops mucrosquamatus Venomous Pit ViperSquamata319 XP_015665555.1 19945.156.7
Bufo bufo Common ToadSalientia353 XP_040276375 13624.734.3
Geotrypetes seraphini Gaboon CaecilianCaecilians353 XP_033813379.1 15636.145.8
Microcaecilia unicolor Tiny CaecilianCaecilians353 XP_030074922.1 14234.342.6
Protopterus annectens West African LungfishActinopterygii408 XP_043910031.1 14228.639

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000183397 – Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000020234 – Ensembl, May 2017
  3. ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. 1 2 3 4 "Homo sapiens tektin bundle interacting protein 1 (TEKTIP1), mRNA". 2022-08-14.
  6. ↑ GeneCard for C19orf71
  7. ↑ "PREDICTED: Homo sapiens tektin bundle interacting protein 1 (TEKTIP1), transcript variant X1, mRNA". 2022-04-05.
  8. 1 2 3 "tektin bundle interacting protein 1 [Homo sapiens] - Protein - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2022-10-20.
  9. 1 2 3 4 "TEKTIP1 tektin bundle interacting protein 1 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2022-12-14.
  10. ↑ Zaragoza K, Bégay V, Schuetz A, Heinemann U, Leutz A (May 2010). "Repression of transcriptional activity of C/EBPalpha by E2F-dimerization partner complexes". Molecular and Cellular Biology. 30 (9): 2293–2304. doi:10.1128/MCB.01619-09. PMC   2863587 . PMID   20176812.
  11. ↑ Wu CL, Zukerberg LR, Ngwu C, Harlow E, Lees JA (May 1995). "In vivo association of E2F and DP family proteins". Molecular and Cellular Biology. 15 (5): 2536–2546. doi:10.1128/MCB.15.5.2536. PMC   230484 . PMID   7739537.
  12. ↑ Helin K, Wu CL, Fattaey AR, Lees JA, Dynlacht BD, Ngwu C, Harlow E (October 1993). "Heterodimerization of the transcription factors E2F-1 and DP-1 leads to cooperative trans-activation". Genes & Development. 7 (10): 1850–1861. doi: 10.1101/gad.7.10.1850 . PMID   8405995.
  13. ↑ Hildesheim J, Foster RA, Chamberlin ME, Vogel JC (September 1999). "Characterization of the regulatory domains of the human skn-1a/Epoc-1/Oct-11 POU transcription factor". The Journal of Biological Chemistry. 274 (37): 26399–26406. doi: 10.1074/jbc.274.37.26399 . PMID   10473598.
  14. ↑ Portney BA, Khatri R, Meltzer WA, Mariano JM, Zalzman M (March 2018). "ZSCAN4 is negatively regulated by the ubiquitin-proteasome system and the E3 ubiquitin ligase RNF20". Biochemical and Biophysical Research Communications. 498 (1): 72–78. doi:10.1016/j.bbrc.2018.02.155. PMC   5928792 . PMID   29477841.
  15. ↑ Bu Q, Huang Y, Li M, Dai Y, Fang X, Chen K, et al. (October 2020). "Acrylamide exposure represses neuronal differentiation, induces cell apoptosis and promotes tau hyperphosphorylation in hESC-derived 3D cerebral organoids". Food and Chemical Toxicology. 144: 111643. doi:10.1016/j.fct.2020.111643. PMID   32763439. S2CID   221073688.
  16. ↑ Lu J, Chen J, Xu N, Wu J, Kang Y, Shen T, et al. (September 2016). "Activation of AIFM2 enhances apoptosis of human lung cancer cells undergoing toxicological stress". Toxicology Letters. 258: 227–236. doi:10.1016/j.toxlet.2016.07.002. PMID   27392435.
  17. ↑ Pisani C, Gaillard JC, Nouvel V, Odorico M, Armengaud J, Prat O (April 2015). "High-throughput, quantitative assessment of the effects of low-dose silica nanoparticles on lung cells: grasping complex toxicity with a great depth of field". BMC Genomics. 16 (1): 315. doi: 10.1186/s12864-015-1521-5 . PMC   4404697 . PMID   25895662.
  18. ↑ Song MK, Lee HS, Ryu JC (August 2015). "Integrated analysis of microRNA and mRNA expression profiles highlights aldehyde-induced inflammatory responses in cells relevant for lung toxicity". Toxicology. 334: 111–121. doi:10.1016/j.tox.2015.06.007. PMID   26079696.
  19. ↑ van Breda SG, Claessen SM, van Herwijnen M, Theunissen DH, Jennen DG, de Kok TM, Kleinjans JC (January 2018). "Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction". Toxicology. 393: 160–170. doi: 10.1016/j.tox.2017.11.013 . PMID   29154799.
  20. ↑ "Expasy - Compute pI/Mw tool". web.expasy.org. Retrieved 2022-12-14.
  21. ↑ "uncharacterized protein C19orf71 isoform X1 [Homo sapiens] - Protein - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2022-10-20.
  22. ↑ "uncharacterized protein C19orf71 isoform X2 [Homo sapiens] - Protein - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2022-10-20.
  23. ↑ "tektin bundle interacting protein 1 isoform X1 [Macaca thibetana thibe - Protein - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2022-10-20.
  24. ↑ "uncharacterized protein C19orf71 homolog isoform X2 [Pan troglodytes] - Protein - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2022-10-20.
  25. ↑ "uncharacterized protein C19orf71 homolog isoform X1 [Papio anubis] - Protein - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2022-10-20.
  26. ↑ "uncharacterized protein C19orf71 homolog isoform X2 [Papio anubis] - Protein - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2022-10-20.
  27. ↑ "uncharacterized protein C19orf71 homolog isoform X1 [Cebus imitator] - Protein - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2022-10-20.
  28. ↑ "uncharacterized protein C19orf71 homolog isoform X2 [Callithrix jacchu - Protein - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2022-10-20.
  29. ↑ "uncharacterized protein C19orf71 homolog isoform X1 [Rhinopithecus rox - Protein - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2022-10-20.
  30. ↑ "PREDICTED: uncharacterized protein C19orf71 homolog isoform X1 [Rhinop - Protein - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2022-10-20.
  31. ↑ "uncharacterized protein C19orf71 homolog isoform X2 [Rhinopithecus rox - Protein - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2022-10-20.
  32. ↑ "uncharacterized protein C19orf71 homolog isoform X1 [Cervus canadensis - Protein - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2022-10-20.
  33. ↑ "uncharacterized protein C19orf71 homolog isoform X2 [Cervus canadensis - Protein - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2022-10-20.
  34. ↑ "uncharacterized protein C19orf71 homolog isoform X1 [Cervus elaphus] - Protein - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2022-10-20.
  35. ↑ "uncharacterized protein C19orf71 homolog isoform X2 [Cervus elaphus] - Protein - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2022-10-20.
  36. ↑ "tektin bundle interacting protein 1 isoform X1 [Rhinolophus ferrumequi - Protein - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2022-10-20.
  37. ↑ "uncharacterized protein C19orf71 homolog isoform X2 [Myotis myotis] - Protein - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2022-10-20.
  38. ↑ "PREDICTED: uncharacterized protein C19orf71 homolog [Myotis brandtii] - Protein - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2022-10-20.
  39. ↑ "tektin bundle interacting protein 1 isoform X2 [Rhinolophus ferrumequi - Protein - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2022-10-20.
  40. ↑ "uncharacterized protein C19orf71 homolog isoform X1 [Vulpes vulpes] - Protein - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2022-10-20.
  41. ↑ "uncharacterized protein C19orf71 homolog isoform X2 [Ursus maritimus] - Protein - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2022-10-20.
  42. ↑ Kelley, Lawrence. "PHYRE2 Protein Fold Recognition Server". www.sbg.bio.ic.ac.uk. Retrieved 2022-12-14.
  43. ↑ "SAPS < Sequence Statistics < EMBL-EBI". www.ebi.ac.uk. Retrieved 2022-12-14.
  44. ↑ "C19orf71 protein expression summary - The Human Protein Atlas". www.proteinatlas.org. Retrieved 2022-12-14.
  45. ↑ "TimeTree :: The Timescale of Life". timetree.org. Retrieved 2022-12-15.
  46. ↑ "uncharacterized protein C19orf71 homolog [Protopterus annectens] - Protein - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2022-12-15.
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