TRNA (adenine57-N1/adenine58-N1)-methyltransferase

TRNA (adenine57-N1/adenine58-N1)-methyltransferase
Identifiers
EC no.	2.1.1.219
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

TRNA (adenine⁵⁷-N¹/adenine⁵⁸-N¹)-methyltransferase (EC 2.1.1.219, TrmI, PabTrmI, AqTrmI, MtTrmI) is an enzyme with systematic name S-adenosyl-L-methionine:tRNA (adenine⁵⁷/adenine⁵⁸-N¹)-methyltransferase. ^{[1] [2]} This enzyme catalyses the following chemical reaction:

2 S-adenosyl-L-methionine + adenine ⁵⁷/adenine⁵⁸ in tRNA ${\displaystyle \rightleftharpoons }$ 2 S-adenosyl-L-homocysteine + N¹-methyladenine⁵⁷/N¹-methyladenine⁵⁸ in tRNA

The enzyme catalyses the formation of N¹-methyladenine at two adjacent positions (57 and 58) in the T-loop of certain tRNAs .

References

1. Roovers M, Wouters J, Bujnicki JM, Tricot C, Stalon V, Grosjean H, Droogmans L (2004). "A primordial RNA modification enzyme: the case of tRNA (m1A) methyltransferase". Nucleic Acids Research. 32 (2): 465–76. doi:10.1093/nar/gkh191. PMC   373318 . PMID   14739239.
2. Guelorget A, Roovers M, Guérineau V, Barbey C, Li X, Golinelli-Pimpaneau B (October 2010). "Insights into the hyperthermostability and unusual region-specificity of archaeal Pyrococcus abyssi tRNA m1A57/58 methyltransferase". Nucleic Acids Research. 38 (18): 6206–18. doi:10.1093/nar/gkq381. PMC   2952851 . PMID   20483913.

External links

• TRNA+(adenine57-N1/adenine58-N1)-methyltransferase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)