TRNA (adenine58-N1)-methyltransferase

TRNA (adenine58-N1)-methyltransferase
Identifiers
EC no.	2.1.1.220
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

TRNA (adenine⁵⁸-N¹)-methyltransferase (EC 2.1.1.220, tRNA m1A58 methyltransferase, tRNA (m1A58) methyltransferase, TrmI, tRNA (m1A58) Mtase, Rv2118cp, Gcd10p-Gcd14p, Trm61p-Trm6p) is an enzyme with systematic name S-adenosyl-L-methionine:tRNA (adenine⁵⁸-N¹)-methyltransferase. ^{[1] [2] [3]} This enzyme catalyses the following chemical reaction

S-adenosyl-L-methionine + adenine ⁵⁸ in tRNA ${\displaystyle \rightleftharpoons }$ S-adenosyl-L-homocysteine + N¹-methyladenine⁵⁸ in tRNA

The enzyme specifically methylates adenine⁵⁸ in tRNA.

References

1. Droogmans L, Roovers M, Bujnicki JM, Tricot C, Hartsch T, Stalon V, Grosjean H (April 2003). "Cloning and characterization of tRNA (m1A58) methyltransferase (TrmI) from Thermus thermophilus HB27, a protein required for cell growth at extreme temperatures". Nucleic Acids Research. 31 (8): 2148–56. doi:10.1093/nar/gkg314. PMC   153742 . PMID   12682365.
2. Varshney U, Ramesh V, Madabushi A, Gaur R, Subramanya HS, RajBhandary UL (2004). "Mycobacterium tuberculosis Rv2118c codes for a single-component homotetrameric m1A58 tRNA methyltransferase". Nucleic Acids Research. 32 (3): 1018–27. doi:10.1093/nar/gkh207. PMC   373377 . PMID   14960715.
3. Anderson J, Phan L, Hinnebusch AG (May 2000). "The Gcd10p/Gcd14p complex is the essential two-subunit tRNA(1-methyladenosine) methyltransferase of Saccharomyces cerevisiae". Proceedings of the National Academy of Sciences of the United States of America. 97 (10): 5173–8. doi: 10.1073/pnas.090102597 . PMC   25801 . PMID   10779558.

External links

• TRNA+(adenine58-N1)-methyltransferase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)