TRNA (guanine9-N1)-methyltransferase

TRNA (guanine9-N1)-methyltransferase
Identifiers
EC no.	2.1.1.221
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

TRNA (guanine⁹-N¹)-methyltransferase (EC 2.1.1.221, Trm10p, tRNA(m1G9/m1A9)-methyltransferase, tRNA(m1G9/m1A9)MTase, tRNA (guanine-N(1)-)-methyltransferase, tRNA m1G9-methyltransferase, tRNA m1G9 MTase) is an enzyme with systematic name S-adenosyl-L-methionine:tRNA (guanine⁹-N¹)-methyltransferase. ^{[1] [2]} This enzyme catalyses the following chemical reaction

S-adenosyl-L-methionine + guanine ⁹ in tRNA ${\displaystyle \rightleftharpoons }$ S-adenosyl-L-homocysteine + N¹-methylguanine⁹ in tRNA

The enzyme from Saccharomyces cerevisiae specifically methylates guanine⁹.

References

1. Kempenaers M, Roovers M, Oudjama Y, Tkaczuk KL, Bujnicki JM, Droogmans L (October 2010). "New archaeal methyltransferases forming 1-methyladenosine or 1-methyladenosine and 1-methylguanosine at position 9 of tRNA". Nucleic Acids Research. 38 (19): 6533–43. doi:10.1093/nar/gkq451. PMC   2965216 . PMID   20525789.
2. Jackman JE, Montange RK, Malik HS, Phizicky EM (May 2003). "Identification of the yeast gene encoding the tRNA m1G methyltransferase responsible for modification at position 9". RNA. 9 (5): 574–85. doi:10.1261/rna.5070303. PMC   1370423 . PMID   12702816.

External links

• TRNA+(guanine9-N1)-methyltransferase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)