1-alkylglycerophosphocholine O-acetyltransferase

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1-alkylglycerophosphocholine O-acetyltransferase
Identifiers
EC no. 2.3.1.67
CAS no. 76773-96-1
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MetaCyc metabolic pathway
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In enzymology, a 1-alkylglycerophosphocholine O-acetyltransferase (EC 2.3.1.67) is an enzyme that catalyzes the chemical reaction

acetyl-CoA + 1-alkyl-sn-glycero-3-phosphocholine CoA + 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine

Thus, the two substrates of this enzyme are acetyl-CoA and 1-alkyl-sn-glycero-3-phosphocholine, whereas its two products are CoA and 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acetyl-CoA:1-alkyl-sn-glycero-3-phosphocholine 2-O-acetyltransferase. Other names in common use include acetyl-CoA:1-alkyl-2-lyso-sn-glycero-3-phosphocholine, 2-O-acetyltransferase, acetyl-CoA:lyso-PAF acetyltransferase, 1-alkyl-2-lysolecithin acetyltransferase, acyl-CoA:1-alkyl-sn-glycero-3-phosphocholine acyltransferase, blood platelet-activating factor acetyltransferase, lyso-GPC:acetyl CoA acetyltransferase, lyso-platelet activating factor:acetyl-CoA acetyltransferase, lysoPAF:acetyl CoA acetyltransferase, PAF acetyltransferase, platelet-activating factor acylhydrolase, platelet-activating factor-synthesizing enzyme, 1-alkyl-2-lyso-sn-glycero-3-phosphocholine acetyltransferase, and lyso-platelet-activating factor:acetyl-CoA acetyltransferase. This enzyme participates in ether lipid metabolism.

Related Research Articles

Platelet-activating factor, also known as PAF, PAF-acether or AGEPC (acetyl-glyceryl-ether-phosphorylcholine), is a potent phospholipid activator and mediator of many leukocyte functions, platelet aggregation and degranulation, inflammation, and anaphylaxis. It is also involved in changes to vascular permeability, the oxidative burst, chemotaxis of leukocytes, as well as augmentation of arachidonic acid metabolism in phagocytes.

<span class="mw-page-title-main">Ether lipid</span>

In an organic chemistry general sense, an ether lipid implies an ether bridge between an alkyl group and an unspecified alkyl or aryl group, not necessarily glycerol. If glycerol is involved, the compound is called a glyceryl ether, which may take the form of an alkylglycerol, an alkyl acyl glycerol, or in combination with a phosphatide group, a phospholipid.

<span class="mw-page-title-main">Platelet-activating factor receptor</span> Protein-coding gene in the species Homo sapiens

The platelet-activating factor receptor(PAF-R) is a G-protein coupled receptor which binds platelet-activating factor. It is encoded in the human by the PTAFR gene.

In enzymology, a phosphatidylcholine desaturase (EC 1.14.19.22, previously EC 1.3.1.35) is an enzyme that catalyzes the chemical reaction

The enzyme 1-alkyl-2-acetylglycerophosphocholine esterase (EC 3.1.1.47) catalyzes the reaction

The enzyme alkylacetylglycerophosphatase (EC 3.1.3.59) catalyzes the reaction

In enzymology, a 1-acylglycerol-3-phosphate O-acyltransferase is an enzyme that catalyzes the chemical reaction

In enzymology, a 1-acylglycerophosphocholine O-acyltransferase is an enzyme that catalyzes the chemical reaction

In enzymology, a 1-alkyl-2-acetylglycerol O-acyltransferase is an enzyme that catalyzes the chemical reaction

In enzymology, a 1-alkylglycerophosphocholine O-acyltransferase is an enzyme that catalyzes the chemical reaction

In enzymology, a 2-acylglycerophosphocholine O-acyltransferase is an enzyme that catalyzes the chemical reaction

In enzymology, an alkylglycerophosphate 2-O-acetyltransferase is an enzyme that catalyzes the chemical reaction

In enzymology, a glycerophospholipid acyltransferase (CoA-dependent) is an enzyme that catalyzes the chemical reaction

In the field of enzymology, a glycerophospholipid arachidonoyl-transferase (CoA-independent) is an enzyme that catalyzes the chemical reaction:

In enzymology, a phosphatidylcholine---dolichol O-acyltransferase is an enzyme that catalyzes the chemical reaction

In enzymology, a plasmalogen synthase is an enzyme that catalyzes the chemical reaction

In enzymology, a platelet-activating factor acetyltransferase is an enzyme that catalyzes the chemical reaction

<span class="mw-page-title-main">Diacylglycerol cholinephosphotransferase</span>

In enzymology, a diacylglycerol cholinephosphotransferase is an enzyme that catalyzes the chemical reaction

<span class="mw-page-title-main">PAFAH2</span> Protein-coding gene in the species Homo sapiens

Platelet-activating factor acetylhydrolase 2, cytoplasmic is an enzyme that in humans is encoded by the PAFAH2 gene. It is one of several PAF acetylhydrolases.

<span class="mw-page-title-main">1-Lysophosphatidylcholine</span>

2-acyl-sn-glycero-3-phosphocholines are a class of phospholipids that are intermediates in the metabolism of lipids. Because they result from the hydrolysis of an acyl group from the sn-1 position of phosphatidylcholine, they are also called 1-lysophosphatidylcholine. The synthesis of phosphatidylcholines with specific fatty acids occurs through the synthesis of 1-lysoPC. The formation of various other lipids generates 1-lysoPC as a by-product.

References