16S rRNA (cytosine967-C5)-methyltransferase

16S rRNA (cytosine967-C5)-methyltransferase
Identifiers
EC no.	2.1.1.176
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

16S rRNA (cytosine⁹⁶⁷-C⁵)-methyltransferase (EC 2.1.1.176, rsmB (gene), fmu (gene), 16S rRNA m5C967 methyltransferase) is an enzyme with systematic name S-adenosyl-L-methionine:16S rRNA (cytosine⁹⁶⁷-C⁵)-methyltransferase. ^{[1] [2] [3]} This enzyme catalyses the following chemical reaction

S-adenosyl-L-methionine + cytosine ⁹⁶⁷ in 16S rRNA ${\displaystyle \rightleftharpoons }$ S-adenosyl-L-homocysteine + 5-methylcytosine ⁹⁶⁷ in 16S rRNA

The enzyme specifically methylates cytosine⁹⁶⁷ at C⁵ in 16S rRNA.

References

1. Tscherne JS, Nurse K, Popienick P, Michel H, Sochacki M, Ofengand J (February 1999). "Purification, cloning, and characterization of the 16S RNA m5C967 methyltransferase from Escherichia coli". Biochemistry. 38 (6): 1884–92. doi:10.1021/bi981880l. PMID   10026269.
2. Gu XR, Gustafsson C, Ku J, Yu M, Santi DV (March 1999). "Identification of the 16S rRNA m5C967 methyltransferase from Escherichia coli". Biochemistry. 38 (13): 4053–7. doi:10.1021/bi982364y. PMID   10194318.
3. Foster PG, Nunes CR, Greene P, Moustakas D, Stroud RM (December 2003). "The first structure of an RNA m5C methyltransferase, Fmu, provides insight into catalytic mechanism and specific binding of RNA substrate". Structure. 11 (12): 1609–20. doi: 10.1016/j.str.2003.10.014 . PMID   14656444.

External links

• 16S+rRNA+(cytosine967-C5)-methyltransferase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)