16S rRNA (guanine1207-N2)-methyltransferase

16S rRNA (guanine1207-N2)-methyltransferase
Identifiers
EC no.	2.1.1.172
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

16S rRNA (guanine¹²⁰⁷-N²)-methyltransferase (EC 2.1.1.172, m2G1207 methyltransferase) is an enzyme with systematic name S-adenosyl-L-methionine:16S rRNA (guanine¹²⁰⁷-N²)-methyltransferase. ^{[1] [2]} This enzyme catalyses the following chemical reaction

S-adenosyl-L-methionine + guanine ¹²⁰⁷ in 16S rRNA ${\displaystyle \rightleftharpoons }$ S-adenosyl-L-homocysteine + N²-methylguanine ¹²⁰⁷ in 16S rRNA

The enzyme reacts well with 30S subunits reconstituted from 16S RNA transcripts and 30S proteins but is almost inactive with the corresponding free RNA.

References

1. Tscherne JS, Nurse K, Popienick P, Ofengand J (January 1999). "Purification, cloning, and characterization of the 16 S RNA m2G1207 methyltransferase from Escherichia coli". The Journal of Biological Chemistry. 274 (2): 924–9. doi: 10.1074/jbc.274.2.924 . PMID   9873033.
2. Sunita S, Purta E, Durawa M, Tkaczuk KL, Swaathi J, Bujnicki JM, Sivaraman J (2007). "Functional specialization of domains tandemly duplicated within 16S rRNA methyltransferase RsmC". Nucleic Acids Research. 35 (13): 4264–74. doi:10.1093/nar/gkm411. PMC   1934991 . PMID   17576679.

External links

• 16S+rRNA+(guanine1207-N2)-methyltransferase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)