16S rRNA (guanine527-N7)-methyltransferase

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16S rRNA (guanine527-N7)-methyltransferase
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EC no. 2.1.1.170
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16S rRNA (guanine527-N7)-methyltransferase (EC 2.1.1.170, ribosomal RNA small subunit methyltransferase G, 16S rRNA methyltransferase RsmG, GidB, rsmG (gene)) is an enzyme with systematic name S-adenosyl-L-methionine:16S rRNA (guanine527-N7)-methyltransferase. [1] [2] This enzyme catalyses the following chemical reaction

S-adenosyl-L-methionine + guanine 527 in 16S rRNA S-adenosyl-L-homocysteine + N7-methylguanine 527 in 16S rRNA

The enzyme specifically methylates guanine527 at N7 in 16S rRNA.

Related Research Articles

<span class="mw-page-title-main">Methyltransferase</span> Group of methylating enzymes

Methyltransferases are a large group of enzymes that all methylate their substrates but can be split into several subclasses based on their structural features. The most common class of methyltransferases is class I, all of which contain a Rossmann fold for binding S-Adenosyl methionine (SAM). Class II methyltransferases contain a SET domain, which are exemplified by SET domain histone methyltransferases, and class III methyltransferases, which are membrane associated. Methyltransferases can also be grouped as different types utilizing different substrates in methyl transfer reactions. These types include protein methyltransferases, DNA/RNA methyltransferases, natural product methyltransferases, and non-SAM dependent methyltransferases. SAM is the classical methyl donor for methyltransferases, however, examples of other methyl donors are seen in nature. The general mechanism for methyl transfer is a SN2-like nucleophilic attack where the methionine sulfur serves as the leaving group and the methyl group attached to it acts as the electrophile that transfers the methyl group to the enzyme substrate. SAM is converted to S-Adenosyl homocysteine (SAH) during this process. The breaking of the SAM-methyl bond and the formation of the substrate-methyl bond happen nearly simultaneously. These enzymatic reactions are found in many pathways and are implicated in genetic diseases, cancer, and metabolic diseases. Another type of methyl transfer is the radical S-Adenosyl methionine (SAM) which is the methylation of unactivated carbon atoms in primary metabolites, proteins, lipids, and RNA.

mRNA (guanine-N7-)-methyltransferase Enzyme

In enzymology, a mRNA (guanine-N7-)-methyltransferase also known as mRNA cap guanine-N7 methyltransferase is an enzyme that catalyzes the chemical reaction

In enzymology, a tRNA (guanine-N7-)-methyltransferase (EC 2.1.1.33) is an enzyme that catalyzes the chemical reaction

16S rRNA (guanine966-N2)-methyltransferase (EC 2.1.1.171, yhhF (gene), rsmD (gene), m2G966 methyltransferase) is an enzyme with systematic name S-adenosyl-L-methionine:16S rRNA (guanine966-N2)-methyltransferase. This enzyme catalyses the following chemical reaction

16S rRNA (guanine1207-N2)-methyltransferase (EC 2.1.1.172, m2G1207 methyltransferase) is an enzyme with systematic name S-adenosyl-L-methionine:16S rRNA (guanine1207-N2)-methyltransferase. This enzyme catalyses the following chemical reaction

16S rRNA (cytosine967-C5)-methyltransferase (EC 2.1.1.176, rsmB (gene), fmu (gene), 16S rRNA m5C967 methyltransferase) is an enzyme with systematic name S-adenosyl-L-methionine:16S rRNA (cytosine967-C5)-methyltransferase. This enzyme catalyses the following chemical reaction

16S rRNA (cytosine1407-C5)-methyltransferase (EC 2.1.1.178, RNA m5C methyltransferase YebU, RsmF, YebU) is an enzyme with systematic name S-adenosyl-L-methionine:16S rRNA (cytosine1407-C5)-methyltransferase. This enzyme catalyses the following chemical reaction

16S rRNA (guanine1405-N7)-methyltransferase (EC 2.1.1.179, methyltransferase Sgm, m7G1405 Mtase, Sgm Mtase, Sgm, sisomicin-gentamicin methyltransferase, sisomicin-gentamicin methylase, GrmA, RmtB, RmtC, ArmA) is an enzyme with systematic name S-adenosyl-L-methionine:16S rRNA (guanine1405-N7)-methyltransferase. This enzyme catalyses the following chemical reaction

16S rRNA (adenine1408-N1)-methyltransferase (EC 2.1.1.180, kanamycin-apramycin resistance methylase, 16S rRNA:m1A1408 methyltransferase, KamB, NpmA, 16S rRNA m1A1408 methyltransferase) is an enzyme with systematic name S-adenosyl-L-methionine:16S rRNA (adenine1408-N1)-methyltransferase. This enzyme catalyses the following chemical reaction

16S rRNA (adenine1518-N6/adenine1519-N6)-dimethyltransferase (EC 2.1.1.182, S-adenosylmethionine-6-N',N'-adenosyl (rRNA) dimethyltransferase, KsgA, ksgA methyltransferase) is an enzyme with systematic name S-adenosyl-L-methionine:16S rRNA (adenine1518-N6/adenine1519-N6)-dimethyltransferase. This enzyme catalyses the following chemical reaction

16S rRNA (uracil1498-N3)-methyltransferase (EC 2.1.1.193, DUF558 protein, YggJ, RsmE, m3U1498 specific methyltransferase) is an enzyme with systematic name S-adenosyl-L-methionine:16S rRNA (uracil1498-N3)-methyltransferase. This enzyme catalyses the following chemical reaction

16S rRNA (cytidine1402-2'-O)-methyltransferase is an enzyme with systematic name S-adenosyl-L-methionine:16S rRNA (cytidine1402-2'-O)-methyltransferase. This enzyme catalyses the following chemical reaction

16S rRNA (cytosine1402-N4)-methyltransferase (EC 2.1.1.199, RsmH, MraW) is an enzyme with systematic name S-adenosyl-L-methionine:16S rRNA (cytosine1402-N4)-methyltransferase. This enzyme catalyses the following chemical reaction

23S rRNA (uridine2479-2'-O)-methyltransferase is an enzyme with systematic name S-adenosyl-L-methionine:23S rRNA (uridine2479-2'-O)-methyltransferase. This enzyme catalyses the following chemical reaction

23S rRNA (guanine2535-N1)-methyltransferase (EC 2.1.1.209, AviRa) is an enzyme with systematic name S-adenosyl-L-methionine:23S rRNA (guanine2535-N1)-methyltransferase. This enzyme catalyses the following chemical reaction

16S rRNA (cytidine1409-2'-O)-methyltransferase (EC 2.1.1.227, TlyA) is an enzyme with systematic name S-adenosyl-L-methionine:16S rRNA (cytidine1409-2'-O)-methyltransferase. This enzyme catalyses the following chemical reaction

tRNA (guanine37-N1)-methyltransferase (EC 2.1.1.228, TrmD, tRNA (m1G37) methyltransferase, transfer RNA (m1G37) methyltransferase, Trm5p, TRMT5, tRNA-(N1G37) methyltransferase, MJ0883 (gene)) is an enzyme with systematic name S-adenosyl-L-methionine:tRNA (guanine37-N1)-methyltransferase. This enzyme catalyses the following chemical reaction

16S rRNA (guanine1516-N2)-methyltransferase (EC 2.1.1.242, yhiQ (gene), rsmJ (gene), m2G1516 methyltransferase) is an enzyme with systematic name S-adenosyl-L-methionine:16S rRNA (guanine1516-N2)-methyltransferase. This enzyme catalyses the following chemical reaction

TRNA (pseudouridine54-N1)-methyltransferase (EC 2.1.1.257, TrmY, m1Psi methyltransferase) is an enzyme with systematic name S-adenosyl-L-methionine:tRNA (pseudouridine54-N1)-methyltransferase. This enzyme catalyses the following chemical reaction

23S rRNA (guanine2069-N7)-methyltransferase (EC 2.1.1.264, rlmK (gene), 23S rRNA m7G2069 methyltransferase) is an enzyme with systematic name S-adenosyl-L-methionine:23S rRNA (guanine2069-N7)-methyltransferase. This enzyme catalyses the following chemical reaction

References

  1. Okamoto S, Tamaru A, Nakajima C, Nishimura K, Tanaka Y, Tokuyama S, Suzuki Y, Ochi K (February 2007). "Loss of a conserved 7-methylguanosine modification in 16S rRNA confers low-level streptomycin resistance in bacteria". Molecular Microbiology. 63 (4): 1096–106. doi: 10.1111/j.1365-2958.2006.05585.x . PMID   17238915.
  2. Romanowski MJ, Bonanno JB, Burley SK (June 2002). "Crystal structure of the Escherichia coli glucose-inhibited division protein B (GidB) reveals a methyltransferase fold". Proteins. 47 (4): 563–7. doi: 10.1002/prot.10121 . PMID   12001236.