2-acylglycerol O-acyltransferase | |||||||||
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Identifiers | |||||||||
EC no. | 2.3.1.22 | ||||||||
CAS no. | 9055-17-8 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, a 2-acylglycerol O-acyltransferase (EC 2.3.1.22) is an enzyme that catalyzes the chemical reaction
Thus, the two substrates of this enzyme are acyl-CoA and 2-acylglycerol, whereas its two products are CoA and diacylglycerol.
This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acyl-CoA:2-acylglycerol O-acyltransferase. Other names in common use include acylglycerol palmitoyltransferase, monoglyceride acyltransferase, acyl coenzyme A-monoglyceride acyltransferase, and monoacylglycerol acyltransferase. This enzyme participates in glycerolipid metabolism.
Monoglycerides are a class of glycerides which are composed of a molecule of glycerol linked to a fatty acid via an ester bond. As glycerol contains both primary and secondary alcohol groups two different types of monoglycerides may be formed; 1-monoacylglycerols where the fatty acid is attached to a primary alcohol, or a 2-monoacylglycerols where the fatty acid is attached to the secondary alcohol.
Monoacylglycerol lipase is an enzyme that, in humans, is encoded by the MGLL gene. MAGL is a 33-kDa, membrane-associated member of the serine hydrolase superfamily and contains the classical GXSXG consensus sequence common to most serine hydrolases. The catalytic triad has been identified as Ser122, His269, and Asp239.
Diglyceride acyltransferase, DGAT, catalyzes the formation of triglycerides from diacylglycerol and fatty acyl-CoA. The reaction catalyzed by DGAT is considered the terminal and only committed step in triglyceride synthesis. The conversion is essential for intestinal absorption and adipose tissue formation.
In enzymology, a 1-acylglycerol-3-phosphate O-acyltransferase is an enzyme that catalyzes the chemical reaction
In enzymology, a 1-alkyl-2-acetylglycerol O-acyltransferase is an enzyme that catalyzes the chemical reaction
In enzymology, a 2-acylglycerol-3-phosphate O-acyltransferase is an enzyme that catalyzes the chemical reaction
In enzymology, a 2-acylglycerophosphocholine O-acyltransferase is an enzyme that catalyzes the chemical reaction
In enzymology, a CDP-acylglycerol O-arachidonoyltransferase was an enzyme construed to catalyze the chemical reaction
In enzymology, a diacylglycerol-sterol O-acyltransferase is an enzyme that catalyzes the chemical reaction
In enzymology, a galactosylacylglycerol O-acyltransferase is an enzyme that catalyzes the chemical reaction
In enzymology, a glycerol-3-phosphate O-acyltransferase is an enzyme that catalyzes the chemical reaction
In enzymology, a long-chain-alcohol O-fatty-acyltransferase is an enzyme that catalyzes the chemical reaction
In enzymology, a phospholipid:diacylglycerol acyltransferase is an enzyme that catalyzes the chemical reaction
In enzymology, a triacylglycerol---sterol O-acyltransferase is an enzyme that catalyzes the chemical reaction
In enzymology, an acylglycerol kinase is an enzyme that catalyzes the chemical reaction
2-Acylglycerol O-acyltransferase 2 also known as acyl-CoA:monoacylglycerol acyltransferase 2 (MGAT2) or Diacylglycerol O-acyltransferase candidate 5 (DC5) is an enzyme that in humans is encoded by the MOGAT2 gene.
2-acyl-sn-glycero-3-phosphocholines are a class of phospholipids that are intermediates in the metabolism of lipids. Because they result from the hydrolysis of an acyl group from the sn-1 position of phosphatidylcholine, they are also called 1-lysophosphatidylcholine. The synthesis of phosphatidylcholines with specific fatty acids occurs through the synthesis of 1-lysoPC. The formation of various other lipids generates 1-lysoPC as a by-product.
A diglyceride, or diacylglycerol (DAG), is a glyceride consisting of two fatty acid chains covalently bonded to a glycerol molecule through ester linkages. Two possible forms exist, 1,2-diacylglycerols and 1,3-diacylglycerols. DAGs can act as surfactants and are commonly used as emulsifiers in processed foods. DAG-enriched oil has been investigated extensively as a fat substitute due to its ability to suppress the accumulation of body fat; with total annual sales of approximately USD 200 million in Japan since its introduction in the late 1990s till 2009.
Glycerol-3-phosphate 2-O-acyltransferase is an enzyme with systematic name acyl-CoA:sn-glycerol 3-phosphate 2-O-acyltransferase. This enzyme catalyses the following chemical reaction
Monoacylglycerol O-acyltransferase 3 is a protein that in humans is encoded by the MOGAT3 gene.