| Date | Rnd | Home | Score | Away | Venue | Tries | Goals | Attendance | 
|---|
| 3 February | 1 |  York City Knights | 0-14 |  Toronto Wolfpack | Bootham Crescent | Mellor, Russell, Wheeler | O’Brien 1/3 | 2,518 | 
| 10 February | 2 |  Rochdale Hornets | 6-58 |  Toronto Wolfpack | Crown Oil Arena | Russell (4), Emmitt, Leutele, Lussick, Mellor, O’Brien, Sidlow, Stanley | O’Brien 7/11 | 694 | 
| 16 February | 3 |  Toronto Wolfpack | 30-6 |  Widnes Vikings | Kingston Park Stadium | Ackers (2), Leutele, Wallace, Wheeler | O’Brien 5/6 | 1,817 | 
| 24 February | 4 |  Leigh Centurions | 8-14 |  Toronto Wolfpack | Leigh Sports Village | Higson, Thompson, Wallace | O’Brien 1/3 | 3,142 | 
| 3 March | 5 |  Dewsbury Rams | 17-22 |  Toronto Wolfpack | Crown Flatt | Brierley, Higson, O’Brien, Wallace | O’Brien 3/4 | 1,251 | 
| 9 March | 6 |  Toulouse Olympique | 46-16 |  Toronto Wolfpack | Stade Ernest-Argelès | Beswick, Leutele, Wallace | O’Brien 2/3 | 6,103 | 
| 17 March | 7 |  Toronto Wolfpack | 34-12 |  Batley Bulldogs | Craven Park | Leutele (2), Russell (2), Dixon, Logan, Wilkin | O’Brien 2/6, Brierley 1/1 | 7,203 [a] | 
| 24 March | 8 |  Halifax | 12-48 |  Toronto Wolfpack | The Shay | Dixon (3), Russell (2), Wallace (2), Rawsthorne, Wilkin | O’Brien 6/9 | 2,090 | 
| 6 April | 9 |  Toronto Wolfpack | 40-10 |  Sheffield Eagles | New River Stadium | Russell (2), Wallace (2), Ackers, Olbison, Sidlow, Stanley | O'Brien 1/4, Wallace 3/4 | 1,148 | 
| 19 April | 10 |  Barrow Raiders | 26-52 |  Toronto Wolfpack | Craven Park | O'Brien (3), Wallace (3), Ackers, Dixon, Russell | Wallace 8/9 | 1,417 | 
| 22 April | 11 |  Featherstone Rovers | 14-23 |  Toronto Wolfpack | Post Office Road | Russell (3), Dixon, O’Brien | Wallace 1/5, McCrone DG | 2,101 | 
| 28 April | 12 |  Toronto Wolfpack | 52-10 |  Swinton Lions | Lamport Stadium | Wallace (2), Ackers, Dixon, Higson, Leutele, O'Brien, Olbison, Thompson | Wallace 8/10 | 9,562 | 
| 4 May | 13 |  Toronto Wolfpack | 36-16 |  Bradford Bulls | Lamport Stadium | Rawsthorne (2), Kay, Leutele, O'Brien, Sidlow, Stanley | O'Brien 4/7 | 8,363 | 
| 18 May | 14 |  Toulouse Olympique | 14-42 |  Toronto Wolfpack | Bloomfield Road | Stanley (3), Lussick, McCrone, O'Brien, Rawsthorne | O'Brien 7/8 | 7,912 | 
| 24 May | 15 |  Sheffield Eagles | 16-42 |  Toronto Wolfpack | Olympic Legacy Park | Dixon (2), Ackers, Kay, Leutele, Rawsthorne, Stanley, Wallace | Wallace 5/8 | 932 | 
| 9 June | 16 |  Swinton Lions | 14-34 |  Toronto Wolfpack | Heywood Road | Leutele (2), Beswick, Dixon, Sidlow, Stanley | Wallace 5/6 | 1,281 | 
| 15 June | 17 |  Toronto Wolfpack | 70-8 |  Dewsbury Rams | Lamport Stadium | Kay (2), Mullally (2), Russell (2), Ackers, Beswick, Mellor, O'Brien, Sidlow, Wallace | O'Brien 11/12 | 6,735 | 
| 22 June | 18 |  Toronto Wolfpack | 28-16 |  Toulouse Olympique | Lamport Stadium | Worthington (2), Ackers, Russell | O'Brien 6/7 | 7,742 | 
| 30 June | 19 |  Batley Bulldogs | 10-40 |  Toronto Wolfpack | The Fox's Biscuits Stadium | Ackers (2), Leutele (2), Russell (2), O'Brien | O'Brien 5/5, Wallace 1/1, Miloudi 0/1 | 894 | 
| 6 July | 20 |  Toronto Wolfpack | 34-12 |  Halifax | Lamport Stadium | O'Brien (2), Ackers, Kay, Olbison | O'Brien 5/6 | 6,749 | 
| 13 July | 21 |  Toronto Wolfpack | 22-18 |  Featherstone Rovers | Lamport Stadium | Leutele, McCrone, O'Brien, Stanley | O'Brien 3/4, Rawsthorne 0/1 | 7,819 | 
| 21 July | 22 |  Widnes Vikings | 19-24 |  Toronto Wolfpack | Halton Stadium | Lussick, Mullally, Rawsthorne, Stanley, Thompson | McCrone 1/4, Miloudi 1/1 | 3,813 | 
| 4 August | 23 |  Bradford Bulls | 20-25 |  Toronto Wolfpack | Odsal Stadium | Leutele (2), Rawsthorne (2), Kay | Wallace 1/3, Miloudi 1/2, Miloudi DG | 3,121 | 
| 10 August | 24 |  Toronto Wolfpack | 56-6 |  York City Knights | Lamport Stadium | O’Brien (3), Ackers (2), McCrone (2), Miloudi (2), Dixon, Rawsthorne, Russell | O’Brien 5/10, Wallace 1/1 | 7,261 | 
| 17 August | 25 |  Toronto Wolfpack | 46-0 |  Rochdale Hornets | Lamport Stadium | Russell (3), O’Brien (2), Stanley (2), Miloudi, Olbison | O’Brien 3/7, Miloudi 2/3 | 5,769 | 
| 31 August | 26 |  Toronto Wolfpack | 62-8 |  Barrow Raiders | Lamport Stadium | Kay (3), Dixon (2), Russell (2), Ackers, McCrone, Mellor, Mullally | O’Brien 9/11 | 7,129 | 
| 7 September | 27 |  Toronto Wolfpack | 46-12 |  Leigh Centurions | Lamport Stadium | McCrone (2), Beswick, Kay, Mellor, Miloudi, O’Brien, Russell | O’Brien 7/8 | 8,152 |